{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have identified a CNS‐specific transcriptional corepressor – a member of the SKI/Sno family – that is selectively expressed in the developing cerebellum. This gene is activated in postmitotic neural progenitors and subsequently becomes a reliable marker for emerging and mature Purkinje cells, as its high expression is restricted to these neurons throughout development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFunctional analyses demonstrate that this corepressor is essential for the proper differentiation of Purkinje cells. Loss‐of‐function experiments reveal that, although initial cell fate specification may occur, a subset of cells displays mixed identities—including aberrant expression of interneuron markers—and fails to fully induce key Purkinje cell marker genes. Additionally, deficient activity of this factor compromises neuronal polarization, migration, dendritic arborization, and the selection and maintenance of the appropriate transmitter phenotype, effects that are at least in part mediated by its regulation of the sonic hedgehog (Shh) pathway through suppression of BMP signaling. Chromatin immunoprecipitation assays further indicate that it binds directly to promoters of several Purkinje cell‐selective genes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional evidence from genetic mapping and comparative evolutionary studies has broadened the view of this gene family’s function. In a genome-wide association study, a genomic interval in the vicinity of this gene was implicated as a candidate underlying female infertility in mice, suggesting roles beyond cerebellar development. Meanwhile, transgenic and biochemical experiments comparing different family members have uncovered distinct, evolutionarily conserved functions that point to potential roles in TGF‑β and insulin signaling, providing a framework for future research into both cerebellar and systemic developmental processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yasuko Minaki, Tomoya Nakatani, Eri Mizuhara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel transcriptional corepressor, Corl2, as a cerebellar Purkinje cell-selective marker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene Expr Patterns (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gep.2008.04.004"}], "href": "https://doi.org/10.1016/j.gep.2008.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18522874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18522874"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Baiping Wang, Wilbur Harrison, Paul A Overbeek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.067264"}], "href": "https://doi.org/10.1242/dev.067264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21937600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21937600"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tomoya Nakatani, Yasuko Minaki, Minoru Kumai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The c-Ski family member and transcriptional regulator Corl2/Skor2 promotes early differentiation of cerebellar Purkinje cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2014.01.016"}], "href": "https://doi.org/10.1016/j.ydbio.2014.01.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24491816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24491816"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ji-Long Liu, Tong-Song Wang, Miao Zhao "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Association Mapping for Female Infertility in Inbred Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "G3 (Bethesda) (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1534/g3.116.031575"}], "href": "https://doi.org/10.1534/g3.116.031575"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27449513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27449513"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Michael J Stinchfield, Keiji Miyazawa, Stuart J Newfeld "}, {"type": "b", "children": [{"type": "t", "text": "Transgenic Analyses in Drosophila Reveal That mCORL1 Is Functionally Distinct from mCORL2 and dCORL."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "G3 (Bethesda) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1534/g3.119.400647"}], "href": "https://doi.org/10.1534/g3.119.400647"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31530634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31530634"}]}]}]}