{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided literature reveals a rich tapestry of studies investigating key cellular and molecular regulatory mechanisms in contexts such as tissue fibrosis, tumor development and metastasis, stem cell regulation, immune cell recruitment, and signal transduction via the Hedgehog/Gli and CXCR2‐mediated pathways. For example, several studies demonstrate the critical roles of perivascular mesenchymal stem cells in fibrosis (e.g., 25465115), CXCR2 signaling in controlling neutrophil recruitment and tumor progression (e.g., 24848257; 24229710; 25799059), and Hedgehog‐mediated transcription via Gli proteins in both normal development and cancer (e.g., 12361967; 17392427; 17638910). These diverse reports underscore the impact of these pathways on inflammation, regeneration, and oncogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, while these studies articulate in detail the functions of factors such as Gli1, CXCR2, and related mediators in varied disease processes, none of the abstracts provide any discussion, experimental data, or inferred biological function regarding NPIPB11. In effect, the literature surveyed here does not link NPIPB11 to the extensive mechanisms described—including stem cell regulation, chemokine‐mediated immune cell trafficking, or Hedgehog pathway activity—leaving its role in these processes unaddressed."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, although the body of work encompassed by these abstracts provides important insights into pathways governing fibrosis, tumor biology, immune cell function, and neuronal as well as osteogenic regeneration, no evidence has been presented that implicates NPIPB11 in any of these phenomena. The lack of any mention—or data addressing potential roles—of NPIPB11 highlights a gap in our understanding; its function remains to be defined and warrants future investigation to determine if and how it might intersect with the expansive signaling networks described in these studies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "29", "end_ref": "41"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "L Del Rio, S Bennouna, J Salinas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCR2 deficiency confers impaired neutrophil recruitment and increased susceptibility during Toxoplasma gondii infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.167.11.6503"}], "href": "https://doi.org/10.4049/jimmunol.167.11.6503"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11714818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11714818"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Johannes F M Pruijt, Perry Verzaal, Ronald van Os, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neutrophils are indispensable for hematopoietic stem cell mobilization induced by interleukin-8 in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.092112999"}], "href": "https://doi.org/10.1073/pnas.092112999"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11983913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11983913"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Junhao Mao, Peter Maye, Priit Kogerman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Gli1 transcriptional activity in the nucleus by Dyrk1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206743200"}], "href": "https://doi.org/10.1074/jbc.M206743200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12138125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12138125"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "C Brian Bai, Wojtek Auerbach, Joon S Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.129.20.4753"}], "href": "https://doi.org/10.1242/dev.129.20.4753"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12361967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12361967"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "John A Belperio, Michael P Keane, Marie D Burdick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI15849"}], "href": "https://doi.org/10.1172/JCI15849"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12464676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12464676"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rebecca L H Bigelow, Nikhil S Chari, Anne Birgitte Unden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M310589200"}], "href": "https://doi.org/10.1074/jbc.M310589200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14555646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14555646"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Michael P Keane, John A Belperio, Ying Y Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Depletion of CXCR2 inhibits tumor growth and angiogenesis in a murine model of lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.172.5.2853"}], "href": "https://doi.org/10.4049/jimmunol.172.5.2853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14978086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14978086"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Richard D Sue, John A Belperio, Marie D Burdick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCR2 is critical to hyperoxia-induced lung injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.172.6.3860"}], "href": "https://doi.org/10.4049/jimmunol.172.6.3860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15004193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15004193"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hiromichi Kimura, Daniel Stephen, Alexandra Joyner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gli1 is important for medulloblastoma formation in Ptc1+/- mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1208567"}], "href": "https://doi.org/10.1038/sj.onc.1208567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15806168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15806168"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ming Chang Hu, Rong Mo, Sita Bhella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.02220"}], "href": "https://doi.org/10.1242/dev.02220"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16396903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16396903"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Erik G Huntzicker, Ivette S Estay, Hanson Zhen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual degradation signals control Gli protein stability and tumor formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1380906"}], "href": "https://doi.org/10.1101/gad.1380906"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16421275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16421275"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jörg Reutershan, Margaret A Morris, Tracy L Burcin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of endothelial CXCR2 in LPS-induced neutrophil migration into the lung."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI27009"}], "href": "https://doi.org/10.1172/JCI27009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16485040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16485040"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lucia Di Marcotullio, Elisabetta Ferretti, Azzura Greco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1510"}], "href": "https://doi.org/10.1038/ncb1510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17115028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17115028"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Steven A Vokes, Hongkai Ji, Scott McCuine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.001966"}], "href": "https://doi.org/10.1242/dev.001966"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17442700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17442700"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sylviane Dennler, Jocelyne André, Ismini Alexaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-0491"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-0491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17638910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17638910"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Fernanda M Coelho, Vanessa Pinho, Flávio A Amaral, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The chemokine receptors CXCR1/CXCR2 modulate antigen-induced arthritis by regulating adhesion of neutrophils to the synovial microvasculature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.23622"}], "href": "https://doi.org/10.1002/art.23622"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18668539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18668539"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Olivier Nolan-Stevaux, Janet Lau, Morgan L Truitt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1753809"}], "href": "https://doi.org/10.1101/gad.1753809"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19136624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19136624"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Barbara Stecca, Ariel Ruiz i Altaba "}, {"type": "b", "children": [{"type": "t", "text": "A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2009.16"}], "href": "https://doi.org/10.1038/emboj.2009.16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19214186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19214186"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jose C Alves-Filho, Andressa Freitas, Fabricio O Souto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0900196106"}], "href": "https://doi.org/10.1073/pnas.0900196106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19234125"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19234125"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Helen Oi-Lam Cheung, Xiaoyun Zhang, Ana Ribeiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2000405"}], "href": "https://doi.org/10.1126/scisignal.2000405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19549984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19549984"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Gianluca Canettieri, Lucia Di Marcotullio, Azzura Greco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2013"}], "href": "https://doi.org/10.1038/ncb2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20081843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20081843"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Weiyi Peng, Yang Ye, Brian A Rabinovich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transduction of tumor-specific T cells with CXCR2 chemokine receptor improves migration to tumor and antitumor immune responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-10-0712"}], "href": "https://doi.org/10.1158/1078-0432.CCR-10-0712"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20889916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20889916"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Zainab Jagani, E Lorena Mora-Blanco, Courtney G Sansam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2251"}], "href": "https://doi.org/10.1038/nm.2251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21076395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21076395"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Anja Köhler, Katia De Filippo, Mike Hasenberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-09-308387"}], "href": "https://doi.org/10.1182/blood-2010-09-308387"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21224471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21224471"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Dalei Wu, Noriko Nishimura, Victoria Kuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-/- mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.110.220202"}], "href": "https://doi.org/10.1161/ATVBAHA.110.220202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21441140"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21441140"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Junjie Mei, Yuhong Liu, Ning Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI60588"}], "href": "https://doi.org/10.1172/JCI60588"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22326959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22326959"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Thomas Jamieson, Mairi Clarke, Colin W Steele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI61067"}], "href": "https://doi.org/10.1172/JCI61067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22922255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22922255"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Scott X Atwood, Mischa Li, Alex Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature11889"}], "href": "https://doi.org/10.1038/nature11889"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23446420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23446420"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Laura Raccosta, Raffaella Fontana, Daniela Maggioni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20130440"}], "href": "https://doi.org/10.1084/jem.20130440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23897983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23897983"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Hiroshi Katoh, Dingzhi Wang, Takiko Daikoku, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2013.10.009"}], "href": "https://doi.org/10.1016/j.ccr.2013.10.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24229710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24229710"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Lei Gong, Amber M Cumpian, Mauricio S Caetano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-12-154"}], "href": "https://doi.org/10.1186/1476-4598-12-154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24321240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24321240"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Rafael Kramann, Rebekka K Schneider, Derek P DiRocco, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2014.11.004"}], "href": "https://doi.org/10.1016/j.stem.2014.11.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25465115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25465115"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Hu Zhao, Jifan Feng, Thach-Vu Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The suture provides a niche for mesenchymal stem cells of craniofacial bones."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3139"}], "href": "https://doi.org/10.1038/ncb3139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25799059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25799059"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Josephine Herz, Pascal Sabellek, Thomas E Lane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of Neutrophils in Exacerbation of Brain Injury After Focal Cerebral Ischemia in Hyperlipidemic Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stroke (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/STROKEAHA.115.010620"}], "href": "https://doi.org/10.1161/STROKEAHA.115.010620"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26337969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26337969"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Jayshree Samanta, Ethan M Grund, Hernandez M Silva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of Gli1 mobilizes endogenous neural stem cells for remyelination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature14957"}], "href": "https://doi.org/10.1038/nature14957"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26416758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26416758"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "P F Yu, Y Huang, Y Y Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNFα-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting CXCR2"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " neutrophils."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.217"}], "href": "https://doi.org/10.1038/onc.2016.217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27375023"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27375023"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Timothy Chao, Emma E Furth, Robert H Vonderheide "}, {"type": "b", "children": [{"type": "t", "text": "CXCR2-Dependent Accumulation of Tumor-Associated Neutrophils Regulates T-cell Immunity in Pancreatic Ductal Adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Immunol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2326-6066.CIR-16-0188"}], "href": "https://doi.org/10.1158/2326-6066.CIR-16-0188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27737879"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27737879"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Vinit Kumar, Laxminarasimha Donthireddy, Douglas Marvel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2017.10.005"}], "href": "https://doi.org/10.1016/j.ccell.2017.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29136508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29136508"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Bahar Degirmenci, Tomas Valenta, Slavica Dimitrieva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41586-018-0190-3"}], "href": "https://doi.org/10.1038/s41586-018-0190-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29875413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29875413"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Diletta Di Mitri, Michela Mirenda, Jelena Vasilevska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2019.07.068"}], "href": "https://doi.org/10.1016/j.celrep.2019.07.068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31433989"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31433989"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Álvaro Teijeira, Saray Garasa, María Gato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2020.03.001"}], "href": "https://doi.org/10.1016/j.immuni.2020.03.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32289253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32289253"}]}]}]}