| Name | nuclear pore complex interacting protein family, member B15 |
| Description | Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nThe current collection of studies focuses on diverse regulatory pathways involving post‐translational modifications of key proteins, such as the unique hypusine modification of eukaryotic initiation factor 5A and the biosynthesis of chondroitin sulfate. For instance, investigations into the roles of deoxyhypusine hydroxylase (DOHH) and eIF5A have revealed their fundamental functions in translational control, embryonic development, and even neurodevelopment and cancer progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " Meanwhile, distinct roles of chondroitin sulfate synthase variants and chondroitin polymerizing factors in the regulation of extracellular matrix biosynthesis and tumor aggressiveness have been elucidated."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, another study highlights the contribution of DOHH in glioblastoma by demonstrating that its overexpression correlates with a more invasive cellular phenotype and poor clinical outcome, thereby emphasizing the therapeutic relevance of targeting hypusine modification pathways in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDespite these advances, none of the referenced abstracts address NPIPB15 directly. As such, while the studies provide comprehensive insights into translational control and extracellular matrix synthesis through proteins like DOHH, eIF5A, CSS1/2, and CHPF, they do not offer experimental evidence or mechanistic details regarding NPIPB15. Consequently, the biological function of NPIPB15 in these contexts remains undefined, underscoring the need for dedicated research to clarify whether NPIPB15 plays a role in similar pathways or represents a distinct regulatory element in cellular homeostasis.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Henning Sievert, Nora Pällmann, Katharine K Miller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Model Mech (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dmm.014449"}], "href": "https://doi.org/10.1242/dmm.014449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24832488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24832488"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nora Pällmann, Melanie Braig, Henning Sievert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biological Relevance and Therapeutic Potential of the Hypusine Modification System."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.664490"}], "href": "https://doi.org/10.1074/jbc.M115.664490"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26037925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26037925"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rajesh Kumar Kar, Ashleigh S Hanner, Matthew F Starost, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2021.101333"}], "href": "https://doi.org/10.1016/j.jbc.2021.101333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34688659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34688659"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hiroyasu Ogawa, Sonoko Hatano, Nobuo Sugiura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0043806"}], "href": "https://doi.org/10.1371/journal.pone.0043806"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22952769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22952769"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hiroyasu Ogawa, Masafumi Shionyu, Nobuo Sugiura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.109553"}], "href": "https://doi.org/10.1074/jbc.M110.109553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20729547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20729547"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zhi-Yuan Yun, Di Wu, Xin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-214-3p overexpression-triggered chondroitin polymerizing factor (CHPF) inhibition modulates the ferroptosis and metabolism in colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12802"}], "href": "https://doi.org/10.1002/kjm2.12802"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38190270"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38190270"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Paula Ofek, Eilam Yeini, Gali Arad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deoxyhypusine hydroxylase: A novel therapeutic target differentially expressed in short-term vs long-term survivors of glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.34545"}], "href": "https://doi.org/10.1002/ijc.34545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37141410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37141410"}]}]}]}
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| Synonyms | NPIPL2, A-761H5.4 |
| Proteins | NPB15_HUMAN |
| NCBI Gene ID | 440348 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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NPIPB15 has 2,101 functional associations with biological entities spanning 5 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 33 datasets.
Click the + buttons to view associations for NPIPB15 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of NPIPB15 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NPIPB15 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of NPIPB15 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of NPIPB15 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with NPIPB15 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of NPIPB15 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NPIPB15 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing NPIPB15 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with NPIPB15 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with NPIPB15 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with NPIPB15 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with NPIPB15 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with NPIPB15 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of NPIPB15 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NPIPB15 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of NPIPB15 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of NPIPB15 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of NPIPB15 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NPIPB15 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of NPIPB15 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of NPIPB15 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of NPIPB15 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NPIPB15 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of NPIPB15 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of NPIPB15 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of NPIPB15 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of NPIPB15 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NPIPB15 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of NPIPB15 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of NPIPB15 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of NPIPB15 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of NPIPB15 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with NPIPB15 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
