NPR2 Gene

HGNC Family	DENN/MADD domain containing (DENND)
Name	natriuretic peptide receptor 2
Description	This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNPR2 encodes the natriuretic peptide receptor‐B (also known as GC‐B), a homodimeric transmembrane guanylyl cyclase that is primarily activated by C‐type natriuretic peptide (CNP). Ligand binding to NPR2 drives the conversion of GTP to cyclic GMP, a second messenger that underlies a host of cellular processes. Detailed biochemical studies have revealed complex regulatory mechanisms for NPR2 activity—including modulation by receptor phosphorylation, ATP binding to an intracellular pseudokinase domain, and processes governing receptor desensitization and trafficking. These mechanisms not only fine‐tune cGMP production in chondrocytes to promote endochondral ossification and axonal bifurcation but also extend into cardiovascular and other paracrine signaling systems."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies have underscored the essential role NPR2 plays in skeletal growth. Loss‐of‐function mutations in NPR2 are linked to severe forms of skeletal dysplasia such as acromesomelic dysplasia, type Maroteaux, and are also associated with milder growth impairments in idiopathic short stature due to receptor haploinsufficiency. Conversely, gain‐of‐function mutations (for example, substitutions that render the receptor constitutively active) lead to enhanced cGMP production in growth plate chondrocytes, culminating in tall stature and overgrowth syndromes. Together, these studies highlight a critical dose–response relationship whereby the extent of NPR2 activation directly determines longitudinal bone growth, and they have important implications for the diagnosis and potential treatment of growth disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "D Rahmutula, T Nakayama, M Soma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Systematic screening of type B human natriuretic peptide receptor gene polymorphisms and association with essential hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Hypertens (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.jhh.1001199"}], "href": "https://doi.org/10.1038/sj.jhh.1001199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11464256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11464256"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "F van den Akker "}, {"type": "b", "children": [{"type": "t", "text": "Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/jmbi.2001.4922"}], "href": "https://doi.org/10.1006/jmbi.2001.4922"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11556325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11556325"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Stephanie Schulz "}, {"type": "b", "children": [{"type": "t", "text": "C-type natriuretic peptide and guanylyl cyclase B receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Peptides (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.peptides.2004.08.027"}], "href": "https://doi.org/10.1016/j.peptides.2004.08.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15911070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15911070"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Laura K Antos, Sarah E Abbey-Hosch, Darcy R Flora, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATP-independent activation of natriuretic peptide receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M505648200"}], "href": "https://doi.org/10.1074/jbc.M505648200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15911610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15911610"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ines Pagel-Langenickel, Jens Buttgereit, Michael Bader, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anesthesiology (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/aln.0b013e31819c7496"}], "href": "https://doi.org/10.1097/aln.0b013e31819c7496"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19326473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19326473"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Deborah M Dickey, Daniel L Dries, Kenneth B Margulies, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A is inactive in the failed cardiomyocyte."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2011.11.007"}], "href": "https://doi.org/10.1016/j.yjmcc.2011.11.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22133375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22133375"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Gohar Ter-Avetisyan, Fritz G Rathjen, Hannes Schmidt "}, {"type": "b", "children": [{"type": "t", "text": "Bifurcation of axons from cranial sensory neurons is disabled in the absence of Npr2-induced cGMP signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4183-13.2014"}], "href": "https://doi.org/10.1523/JNEUROSCI.4183-13.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24431432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24431432"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Aaron B Edmund, Timothy F Walseth, Nicholas M Levinson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The pseudokinase domains of guanylyl cyclase-A and -B allosterically increase the affinity of their catalytic domains for substrate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aau5378"}], "href": "https://doi.org/10.1126/scisignal.aau5378"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30696704"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30696704"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Cynthia F Bartels, Hulya Bükülmez, Pius Padayatti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/422013"}], "href": "https://doi.org/10.1086/422013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15146390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15146390"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kohji Miura, Noriyuki Namba, Makoto Fujiwara, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature in patients initially classified as idiopathic short stature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2013-2142"}], "href": "https://doi.org/10.1210/jc.2013-2142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24001744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24001744"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Kohji Miura, Ok-Hwa Kim, Hey Ran Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overgrowth syndrome associated with a gain-of-function mutation of the natriuretic peptide receptor 2 (NPR2) gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.36218"}], "href": "https://doi.org/10.1002/ajmg.a.36218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24259409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24259409"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Naoko Amano, Tokuo Mukai, Yoshiya Ito, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22773"}], "href": "https://doi.org/10.1002/humu.22773"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25703509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25703509"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": " Irfanullah, Muhammad Umair, Saadullah Khan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homozygous sequence variants in the NPR2 gene underlying Acromesomelic dysplasia Maroteaux type (AMDM) in consanguineous families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ahg.12116"}], "href": "https://doi.org/10.1111/ahg.12116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25959430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25959430"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Alfonso Hisado-Oliva, Ana I Garre-Vázquez, Fabiola Santaolalla-Caballero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterozygous NPR2 Mutations Cause Disproportionate Short Stature, Similar to Léri-Weill Dyschondrosteosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2015-1612"}], "href": "https://doi.org/10.1210/jc.2015-1612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26075495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26075495"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Wei Wang, Mi Hyun Song, Kohji Miura, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Differential expression and regulation of anti-hypertrophic genes Npr1 and Npr2 during β-adrenergic receptor activation-induced hypertrophic growth in rats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2016.06.010"}], "href": "https://doi.org/10.1016/j.mce.2016.06.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27283501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27283501"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Gabriela A Vasques, Alfonso Hisado-Oliva, Mariana F A Funari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long-term response to growth hormone therapy in a patient with short stature caused by a novel heterozygous mutation in NPR2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pediatr Endocrinol Metab (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/jpem-2016-0280"}], "href": "https://doi.org/10.1515/jpem-2016-0280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27941173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27941173"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": " Irfanullah, Amir Zeb, Naila Shinwari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular and in silico analyses validates pathogenicity of homozygous mutations in the NPR2 gene underlying variable phenotypes of Acromesomelic dysplasia, type Maroteaux."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2018.07.004"}], "href": "https://doi.org/10.1016/j.biocel.2018.07.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30016695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30016695"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Noor Ul Ain, Muddassar Iqbal, Helena Valta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel variants in natriuretic peptide receptor 2 in unrelated patients with acromesomelic dysplasia type Maroteaux."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2018.10.006"}], "href": "https://doi.org/10.1016/j.ejmg.2018.10.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30359775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30359775"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Lukas Plachy, Petra Dusatkova, Klara Maratova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NPR2 Variants Are Frequent among Children with Familiar Short Stature and Respond Well to Growth Hormone Therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/clinem/dgaa037"}], "href": "https://doi.org/10.1210/clinem/dgaa037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31990356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31990356"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Patrick C Hanley, Harsh S Kanwar, Corine Martineau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Short Stature is Progressive in Patients with Heterozygous NPR2 Mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/clinem/dgaa491"}], "href": "https://doi.org/10.1210/clinem/dgaa491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32720985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32720985"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Xiaoan Ke, Hanting Liang, Hui Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical Characteristics of Short-Stature Patients With an NPR2 Mutation and the Therapeutic Response to rhGH."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/clinem/dgaa842"}], "href": "https://doi.org/10.1210/clinem/dgaa842"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33205215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33205215"}]}]}]}
Synonyms	GUCY2B, ANPRB, NPRBI, ECDM, NPRB, ANPB, GUC2B, AMDM, SNSK
Proteins	ANPRB_HUMAN
NCBI Gene ID	4882
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NPR2 has 7,504 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 124 datasets.

Click the + buttons to view associations for NPR2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NPR2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by NPR2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NPR2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NPR2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NPR2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NPR2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NPR2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NPR2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NPR2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NPR2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NPR2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of NPR2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NPR2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NPR2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with NPR2 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NPR2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NPR2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NPR2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NPR2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with NPR2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NPR2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NPR2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing NPR2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NPR2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NPR2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NPR2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NPR2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NPR2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NPR2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NPR2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NPR2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NPR2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NPR2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NPR2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for NPR2 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NPR2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NPR2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NPR2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NPR2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with NPR2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with NPR2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.