{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNAD(P)H:quinone oxidoreductase 1 (NQO1) is a cytosolic flavoprotein that catalyzes the two‐electron reduction of quinones into hydroquinones, thereby preventing the formation of reactive oxygen species through redox cycling and protecting cells against oxidative stress. Its expression is tightly controlled by the antioxidant response element (ARE) through Nrf2, with modulation by redox‐sensitive regulators such as Bach1 and Nrf3. In endothelial, hepatic, and keratinocyte models, NQO1—as part of a suite of phase‑II detoxification enzymes—is induced by laminar shear stress, electrophilic fatty acids, nitric oxide, and even melatonin, contributing to cytoprotection from oxidative injury and inflammatory insults."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its detoxification function, NQO1 also serves important roles in protein stabilization. By interacting directly with proteins such as p53 and ornithine decarboxylase (ODC), NQO1 can prevent their ubiquitin‑independent degradation via the 20S proteasome, thereby influencing apoptotic thresholds and cell cycle regulation. This stabilization function is implicated in modulating inflammatory responses in monocytes and in maintaining neuronal integrity under stress conditions, as seen in models of Alzheimer’s disease and Parkinson’s disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic polymorphisms affecting NQO1 activity have been linked to altered susceptibility to various cancers—including leukemia, lung, colorectal, bladder, and breast carcinomas—and can modulate responses to environmental toxicants such as benzene. NQO1 overexpression in numerous solid tumors has also been associated with chemoresistance (to agents like anthracyclines and oxaliplatin) and poor patient prognosis, highlighting its potential as both a biomarker and therapeutic target. Its regulation via Nrf2 signaling and interplay with other enzymes (for example, catalase) further emphasizes a complex role for NQO1 in gene–environment interactions and cellular defense mechanisms."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "29", "end_ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "T Naoe, K Takeyama, T Yokozawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of genetic polymorphism in NQO1, GST-M1, GST-T1, and CYP3A4 in 469 Japanese patients with therapy-related leukemia/ myelodysplastic syndrome and de novo acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2000)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11051261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11051261"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "S Harada, C Fujii, A Hayashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/bbrc.2001.5868"}], "href": "https://doi.org/10.1006/bbrc.2001.5868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11688992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11688992"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ellen L Goode, Alison M Dunning, Bettina Kuschel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of germ-line genetic variation on breast cancer survival in a population-based study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12036913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12036913"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Noriaki Sunaga, Takashi Kohno, Noriko Yanagitani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12163326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12163326"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gad Asher, Joseph Lotem, Leo Sachs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.202480499"}], "href": "https://doi.org/10.1073/pnas.202480499"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12232053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12232053"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xi-Lin Chen, Signe E Varner, Anjali S Rao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M203161200"}], "href": "https://doi.org/10.1074/jbc.M203161200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12370194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12370194"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Claire Seedhouse, Rowena Bainton, Michael Lewis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-04-1152"}], "href": "https://doi.org/10.1182/blood-2002-04-1152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12393447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12393447"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Martyn T Smith, Yunxia Wang, Christine F Skibola, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low NAD(P)H:quinone oxidoreductase activity is associated with increased risk of leukemia with MLL translocations in infants and children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2001-12-0264"}], "href": "https://doi.org/10.1182/blood-2001-12-0264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12393620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12393620"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Christoph Sachse, Gillian Smith, Murray J V Wilkie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/23.11.1839"}], "href": "https://doi.org/10.1093/carcin/23.11.1839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12419832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12419832"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Javier G Blanco, Mathew J Edick, Michael L Hancock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms in CYP3A5, CYP3A4 and NQO1 in children who developed therapy-related myeloid malignancies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenetics (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/00008571-200211000-00004"}], "href": "https://doi.org/10.1097/00008571-200211000-00004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12439220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12439220"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Junxiang Wan, Jinxiu Shi, Lijian Hui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of genetic polymorphisms in CYP2E1, MPO, NQO1, GSTM1, and GSTT1 genes with benzene poisoning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Health Perspect (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1289/ehp.021101213"}], "href": "https://doi.org/10.1289/ehp.021101213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12460800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12460800"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Stefan Wilkening, Frank Stahl, Augustinus Bader "}, {"type": "b", "children": [{"type": "t", "text": "Comparison of primary human hepatocytes and hepatoma cell line Hepg2 with regard to their biotransformation properties."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Dispos (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/dmd.31.8.1035"}], "href": "https://doi.org/10.1124/dmd.31.8.1035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12867492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12867492"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Karen S SantaCruz, Eugenia Yazlovitskaya, Julie Collins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regional NAD(P)H:quinone oxidoreductase activity in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0197-4580(03)00117-9"}], "href": "https://doi.org/10.1016/s0197-4580(03"}, {"type": "t", "text": "00117-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14675732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14675732"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Somali Sanyal, Fabiola Festa, Shigeru Sakano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in DNA repair and metabolic genes in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgh058"}], "href": "https://doi.org/10.1093/carcin/bgh058"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14688016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14688016"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Rayjean J Hung, Paolo Boffetta, Paul Brennan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms of MPO, COMT, MnSOD, NQO1, interactions with environmental exposures and bladder cancer risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgh080"}], "href": "https://doi.org/10.1093/carcin/bgh080"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14729580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14729580"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Saravanakumar Dhakshinamoorthy, Alan G Porter "}, {"type": "b", "children": [{"type": "t", "text": "Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts apoptosis of neuroblastoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312492200"}], "href": "https://doi.org/10.1074/jbc.M312492200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14985350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14985350"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kannan Sankaranarayanan, Anil K Jaiswal "}, {"type": "b", "children": [{"type": "t", "text": "Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M404984200"}], "href": "https://doi.org/10.1074/jbc.M404984200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15385560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15385560"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Saravanakumar Dhakshinamoorthy, Abhinav K Jain, David A Bloom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M500166200"}], "href": "https://doi.org/10.1074/jbc.M500166200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15734732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15734732"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Karin Broberg, Jonas Björk, Karin Paulsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgi063"}], "href": "https://doi.org/10.1093/carcin/bgi063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15746160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15746160"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Gad Asher, Zippi Bercovich, Peter Tsvetkov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "20S proteasomal degradation of ornithine decarboxylase is regulated by NQO1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2005.01.020"}], "href": "https://doi.org/10.1016/j.molcel.2005.01.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15749015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15749015"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Silvia Fustinoni, Dario Consonni, Laura Campo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Monitoring low benzene exposure: comparative evaluation of urinary biomarkers, influence of cigarette smoking, and genetic polymorphisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-04-0798"}], "href": "https://doi.org/10.1158/1055-9965.EPI-04-0798"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16172237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16172237"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Joshua Millstein, David V Conti, Frank D Gilliland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A testing framework for identifying susceptibility genes in the presence of epistasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/498850"}], "href": "https://doi.org/10.1086/498850"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16385446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16385446"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Chun Chao, Zuo-Feng Zhang, Julien Berthiller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAD(P)H:quinone oxidoreductase 1 (NQO1) Pro187Ser polymorphism and the risk of lung, bladder, and colorectal cancers: a meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-05-0899"}], "href": "https://doi.org/10.1158/1055-9965.EPI-05-0899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16702380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16702380"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Chi-Chen Hong, Christine B Ambrosone, Jiyoung Ahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variability in iron-related oxidative stress pathways (Nrf2, NQ01, NOS3, and HO-1), iron intake, and risk of postmenopausal breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-07-0247"}], "href": "https://doi.org/10.1158/1055-9965.EPI-07-0247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17726138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17726138"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Javier G Blanco, Wendy M Leisenring, Vanessa M Gonzalez-Covarrubias, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cncr.23534"}], "href": "https://doi.org/10.1002/cncr.23534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18457324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18457324"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Rainer Fagerholm, Barbara Hofstetter, Johanna Tommiska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.155"}], "href": "https://doi.org/10.1038/ng.155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18511948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18511948"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Stuart A Rushworth, David J MacEwan, Maria A O'Connell "}, {"type": "b", "children": [{"type": "t", "text": "Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.181.10.6730"}], "href": "https://doi.org/10.4049/jimmunol.181.10.6730"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18981090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18981090"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Suleeporn Sangrajrang, Yasunori Sato, Hiromi Sakamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.24434"}], "href": "https://doi.org/10.1002/ijc.24434"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19415745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19415745"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Emilia Kansanen, Henna-Kaisa Jyrkkänen, Oscar L Volger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.064873"}], "href": "https://doi.org/10.1074/jbc.M109.064873"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19808663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19808663"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Irina Mordukhovich, Elissa Wilker, Helen Suh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Black carbon exposure, oxidative stress genes, and blood pressure in a repeated-measures study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Health Perspect (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1289/ehp.0900591"}], "href": "https://doi.org/10.1289/ehp.0900591"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20049130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20049130"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Emmanuel S Baja, Joel D Schwartz, Gregory A Wellenius, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Traffic-related air pollution and QT interval: modification by diabetes, obesity, and oxidative stress gene polymorphisms in the normative aging study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Environ Health Perspect (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1289/ehp.0901396"}], "href": "https://doi.org/10.1289/ehp.0901396"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20194081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20194081"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Jayaram Vijayakrishnan, Richard S Houlston "}, {"type": "b", "children": [{"type": "t", "text": "Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: a systematic review and meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2010.022095"}], "href": "https://doi.org/10.3324/haematol.2010.022095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20511665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20511665"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Erik A Bey, Kathryn E Reinicke, Melissa C Srougi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-12-0962"}], "href": "https://doi.org/10.1158/1535-7163.MCT-12-0962"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23883585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23883585"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Yang Yang, Yan Zhang, Qunying Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical implications of high NQO1 expression in breast cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1756-9966-33-14"}], "href": "https://doi.org/10.1186/1756-9966-33-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24499631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24499631"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Song Chian, Yin-Yan Li, Xiu-Jun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Luteolin sensitizes two oxaliplatin-resistant colorectal cancer cell lines to chemotherapeutic drugs via inhibition of the Nrf2 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2014.15.6.2911"}], "href": "https://doi.org/10.7314/apjcp.2014.15.6.2911"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24761924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24761924"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Konrad Kleszczyński, Detlef Zillikens, Tobias W Fischer "}, {"type": "b", "children": [{"type": "t", "text": "Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (γ-GCS, HO-1, NQO1) in ultraviolet radiation-treated normal human epidermal keratinocytes (NHEK)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pineal Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jpi.12338"}], "href": "https://doi.org/10.1111/jpi.12338"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27117941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27117941"}]}]}]}