NRBF2 Gene

Name	nuclear receptor binding factor 2
Description	Involved in autophagy. Located in cytoplasm and phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNRBF2 serves as a pivotal regulator of autophagy by dynamically modulating the assembly and activity of the class III phosphatidylinositol 3‐kinase complex I. It directly interacts with core components—including ATG14, Beclin 1, VPS34, and VPS15—to enhance lipid kinase activity and promote autophagosome biogenesis. Moreover, NRBF2’s function is fine-tuned by mTORC1-mediated phosphorylation at specific serine residues; when unphosphorylated, it preferentially associates with ATG14/Beclin 1 to boost autophagic flux, whereas its phosphorylated state directs binding toward VPS34/VPS15 and attenuates the lipid kinase function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its central role in autophagy initiation, NRBF2 contributes to the maintenance of cellular homeostasis in diverse pathological contexts. In neuronal cells, it facilitates the autophagic clearance of amyloid precursor protein (APP) C-terminal fragments, thereby modulating amyloid‐β homeostasis and suggesting therapeutic relevance in Alzheimer’s disease. Complementarily, chromatin conformation studies have linked regulatory variants associated with NRBF2 to altered gene expression in breast cancer, implicating NRBF2 in tumor etiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNRBF2 further influences inflammatory responses and therapy resistance in cancer. In murine models of colitis, it is essential for the maturation of phagosomes and the efficient clearance of apoptotic cells through the activation of RAB7 via the MON1-CCZ1 complex, thereby mitigating intestinal inflammation. In glioblastoma, upregulation of NRBF2-driven autophagy reprograms cellular metabolism and contributes to radioresistance, highlighting NRBF2 as a potential target for overcoming therapeutic resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanyan Cao, Yichen Wang, Widian F Abi Saab, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NRBF2 regulates macroautophagy as a component of Vps34 Complex I."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20140515"}], "href": "https://doi.org/10.1042/BJ20140515"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24785657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24785657"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yu Zhong, Deanna H Morris, Lin Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.561134"}], "href": "https://doi.org/10.1074/jbc.M114.561134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25086043"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25086043"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lindsey N Young, Kelvin Cho, Rosalie Lawrence, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1603650113"}], "href": "https://doi.org/10.1073/pnas.1603650113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27385829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27385829"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yohei Ohashi, Nicolas Soler, Miguel García Ortegón, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of Atg38 and NRBF2, a fifth subunit of the autophagic Vps34/PIK3C3 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2016.1226736"}], "href": "https://doi.org/10.1080/15548627.2016.1226736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27630019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27630019"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xi Ma, Shen Zhang, Long He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2016.1269988"}], "href": "https://doi.org/10.1080/15548627.2016.1269988"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28059666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28059666"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hatef Darabi, Karen McCue, Jonathan Beesley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2015.05.002"}], "href": "https://doi.org/10.1016/j.ajhg.2015.05.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26073781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26073781"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chuanbin Yang, Cui-Zan Cai, Ju-Xian Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NRBF2 is involved in the autophagic degradation process of APP-CTFs in Alzheimer disease models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2017.1379633"}], "href": "https://doi.org/10.1080/15548627.2017.1379633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28980867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28980867"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Catherine Bélanger, Tatiana Cardinal, Elizabeth Leduc, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202100837RR"}], "href": "https://doi.org/10.1096/fj.202100837RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35129866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35129866"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jeongha Kim, Hyunkoo Kang, Beomseok Son, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NRBF2-mediated autophagy contributes to metabolite replenishment and radioresistance in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s12276-022-00873-2"}], "href": "https://doi.org/10.1038/s12276-022-00873-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36333468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36333468"}]}]}]}
Synonyms	COPR1, COPR2, COPR, NRBF-2
Proteins	NRBF2_HUMAN
NCBI Gene ID	29982
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NRBF2 has 5,798 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 105 datasets.

Click the + buttons to view associations for NRBF2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NRBF2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NRBF2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NRBF2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NRBF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NRBF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NRBF2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of NRBF2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NRBF2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NRBF2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NRBF2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NRBF2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NRBF2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NRBF2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NRBF2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NRBF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NRBF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing NRBF2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of NRBF2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NRBF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NRBF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NRBF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NRBF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NRBF2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NRBF2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NRBF2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NRBF2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NRBF2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by NRBF2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NRBF2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NRBF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NRBF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NRBF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NRBF2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NRBF2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NRBF2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NRBF2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of NRBF2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with NRBF2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing NRBF2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of NRBF2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of NRBF2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.