{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNeurogranin (NRGN) is a brain‐specific, postsynaptic protein that plays a pivotal role in modulating intracellular calcium signaling. By binding calmodulin via its IQ motif in a calcium‐sensitive manner, NRGN regulates the availability of calmodulin for downstream signaling cascades that underlie synaptic plasticity, long‐term potentiation, and ultimately learning and memory. This molecular regulation has been demonstrated in studies of both neuronal and non‐neuronal cells, where ectopic expression of NRGN (also known as RC3) modulates intracellular Ca²⁺ levels and triggers Ca²⁺‐dependent events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic investigations have implicated NRGN in neuropsychiatric conditions. Several genome‐wide association and candidate gene studies have identified risk variants—such as those located upstream of the NRGN gene—that are associated with disorders including schizophrenia and bipolar disorder, as well as with cognitive deficits. In affected individuals, alterations in NRGN expression and haplotype variability have been linked to abnormal neural activation patterns during memory tasks, reduced immunoreactivity in key prefrontal regions, and even global cognitive impairments when NRGN is affected by larger chromosomal deletions. These findings support the notion that genetic variability in NRGN contributes to disrupted glutamatergic signaling and synaptic function underlying psychiatric disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its molecular and genetic significance, neurogranin has emerged as an informative fluid biomarker in neurodegenerative conditions and brain injuries. In Alzheimer’s disease, for example, cerebrospinal fluid levels of NRGN are consistently elevated even in predementia stages, a reflection of early synaptic loss that correlates with cognitive decline, reduced glucose metabolism and hippocampal atrophy. Similar efforts have evaluated NRGN as a blood or CSF biomarker in other contexts, including traumatic brain injury and even aspects of Parkinson’s disease pathology, where changes in its post‐translational processing and interactions with proteins like α‐synuclein have been documented. Collectively, these studies underscore that aberrant NRGN levels are not only indicative of disturbed synaptic integrity but also provide a window into the ongoing neurodegenerative processes and neuronal injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "40"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Laxminarayana R Devireddy, Michael R Green "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional program of apoptosis induction following interleukin 2 deprivation: identification of RC3, a calcium/calmodulin binding protein, as a novel proapoptotic factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.13.4532-4541.2003"}], "href": "https://doi.org/10.1128/MCB.23.13.4532-4541.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12808095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12808095"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Laurel Hoffman, Anuja Chandrasekar, Xu Wang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Association of the gene encoding neurogranin with schizophrenia in males."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Psychiatr Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jpsychires.2006.10.008"}], "href": "https://doi.org/10.1016/j.jpsychires.2006.10.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17140601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17140601"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "C D Coldren, Z Lai, P Shragg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromosomal microarray mapping suggests a role for BSX and Neurogranin in neurocognitive and behavioral defects in the 11q terminal deletion disorder (Jacobsen syndrome)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-008-0157-x"}], "href": "https://doi.org/10.1007/s10048-008-0157-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18855024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18855024"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hreinn Stefansson, Roel A Ophoff, Stacy Steinberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants conferring risk of schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08186"}], "href": "https://doi.org/10.1038/nature08186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19571808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19571808"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Annika Thorsell, Maria Bjerke, Johan Gobom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2010.09.073"}], "href": "https://doi.org/10.1016/j.brainres.2010.09.073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20875798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20875798"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hywel J Williams, Nicholas Craddock, Giancarlo Russo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Most genome-wide significant susceptibility loci for schizophrenia and bipolar disorder reported to date cross-traditional diagnostic boundaries."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddq471"}], "href": "https://doi.org/10.1093/hmg/ddq471"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21037240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21037240"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rhodri Ll Smith, Deborah Knight, Hywel Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of neurogranin (NRGN) in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.31191"}], "href": "https://doi.org/10.1002/ajmg.b.31191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21538840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21538840"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Axel Krug, Sören Krach, Andreas Jansen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of neurogranin on neural correlates of episodic memory encoding and retrieval."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Schizophr Bull (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/schbul/sbr076"}], "href": "https://doi.org/10.1093/schbul/sbr076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21799211"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21799211"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kazutaka Ohi, Ryota Hashimoto, Yuka Yasuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of the genome wide supported NRGN gene on anterior cingulate morphology in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0029780"}], "href": "https://doi.org/10.1371/journal.pone.0029780"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22253779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22253779"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kazutaka Ohi, Ryota Hashimoto, Yuka Yasuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional genetic variation at the NRGN gene and schizophrenia: evidence from a gene-based case-control study and gene expression analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.32043"}], "href": "https://doi.org/10.1002/ajmg.b.32043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22461181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22461181"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Emma J Rose, Derek W Morris, Ciara Fahey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effect of the neurogranin schizophrenia risk variant rs12807809 on brain structure and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Twin Res Hum Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1017/thg.2012.7"}], "href": "https://doi.org/10.1017/thg.2012.7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22856365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22856365"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Kazutaka Ohi, Ryota Hashimoto, Yuka Yasuda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Influence of the NRGN gene on intellectual ability in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2013.82"}], "href": "https://doi.org/10.1038/jhg.2013.82"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23903071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23903071"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Esther Walton, Daniel Geisler, Johanna Hass, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0076815"}], "href": "https://doi.org/10.1371/journal.pone.0076815"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24098564"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24098564"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jamie Yu Jin Thong, Anqi Qiu, Min Yi Sum, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.brainres.2014.10.013"}], "href": "https://doi.org/10.1016/j.brainres.2014.10.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25446004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25446004"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jun Yang, Frederick K Korley, Min Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum neurogranin measurement as a biomarker of acute traumatic brain injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinbiochem.2015.05.015"}], "href": "https://doi.org/10.1016/j.clinbiochem.2015.05.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26025774"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26025774"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Maartje I Kester, Charlotte E Teunissen, Daniel L Crimmins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurogranin as a Cerebrospinal Fluid Biomarker for Synaptic Loss in Symptomatic Alzheimer Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JAMA Neurol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/jamaneurol.2015.1867"}], "href": "https://doi.org/10.1001/jamaneurol.2015.1867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26366630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26366630"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Erik Portelius, Henrik Zetterberg, Tobias Skillbäck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cerebrospinal fluid neurogranin: relation to cognition and neurodegeneration in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awv267"}], "href": "https://doi.org/10.1093/brain/awv267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26373605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26373605"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Konstantin Hellwig, Hlin Kvartsberg, Erik Portelius, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Alzheimers Res Ther (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13195-015-0161-y"}], "href": "https://doi.org/10.1186/s13195-015-0161-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26698298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26698298"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Henrietta Wellington, Ross W Paterson, Erik Portelius, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased CSF neurogranin concentration is specific to Alzheimer disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000002423"}], "href": "https://doi.org/10.1212/WNL.0000000000002423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26826204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26826204"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Rawan Tarawneh, Gina D'Angelo, Dan Crimmins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JAMA Neurol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/jamaneurol.2016.0086"}], "href": "https://doi.org/10.1001/jamaneurol.2016.0086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27018940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27018940"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Julia Remnestål, David Just, Nicholas Mitsios, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics Clin Appl (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/prca.201500150"}], "href": "https://doi.org/10.1002/prca.201500150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27604409"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27604409"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Ravi Sudesh, Thirunavukkarasu Priyadarshini, Rajendran Preeti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Minor allele C of rs12807809 polymorphism in NRGN contributes to the severity of psychosis in patients with Schizophrenia in South Indian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2017.04.008"}], "href": "https://doi.org/10.1016/j.neulet.2017.04.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28389239"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28389239"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Ann De Vos, Maria Bjerke, Raf Brouns, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neurogranin and tau in cerebrospinal fluid and plasma of patients with acute ischemic stroke."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Neurol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12883-017-0945-8"}], "href": "https://doi.org/10.1186/s12883-017-0945-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28854881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28854881"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Alison Headley, Andres De Leon-Benedetti, Chuanhui Dong, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Neurogranin as Cerebrospinal Fluid Biomarker for Alzheimer Disease: An Assay Comparison Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1373/clinchem.2017.283028"}], "href": "https://doi.org/10.1373/clinchem.2017.283028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29523639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29523639"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Erik Portelius, Bob Olsson, Kina Höglund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-018-1851-x"}], "href": "https://doi.org/10.1007/s00401-018-1851-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29700597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29700597"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Yifan Zhang, Xiaohong Gong, Zhiyang Yin, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The association between rs12807809 polymorphism in neurogranin gene and risk of schizophrenia: A meta-analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000018518"}], "href": "https://doi.org/10.1097/MD.0000000000018518"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31861040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31861040"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Frederic Brosseron, Kilian Kleemann, Carl-Christian Kolbe, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Brain "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "CHID1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Expression Correlates with "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "NRGN"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "CALB1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in Healthy Subjects and AD Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10040882"}], "href": "https://doi.org/10.3390/cells10040882"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33924468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33924468"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Pia Kivisäkk, Becky C Carlyle, Thadryan Sweeney, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Neurogranin expression regulates mitochondrial function and redox balance in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Redox Biol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.redox.2024.103085"}], "href": "https://doi.org/10.1016/j.redox.2024.103085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38359746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38359746"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Vanesa Jurasova, Ross Andel, Alzbeta Katonova, et al. 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