{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNetrin‐1 is well established as a versatile axon guidance cue with fundamental roles in neural development. It directs the migration, targeting, and branching of axons and dendrites, and promotes synaptogenesis and neuronal survival through its interactions with receptors such as DCC, UNC5, and DSCAM. In addition, netrin‐1’s binding to these receptors—including its regulated association with lipid‐rafts and its ability to trigger receptor ubiquitination—helps refine growth cone responses and even support appropriate midline crossing, as illustrated by mutations that disrupt corticospinal decussation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its developmental roles, netrin‐1 exerts potent immunomodulatory and vascular effects. Under conditions of hypoxia, infection, or injury, netrin‐1 is induced in epithelial and endothelial cells as well as in macrophages, where it restrains excessive inflammation by inhibiting leukocyte migration and by promoting vascular barrier integrity. In diverse contexts—including mucosal inflammation, acute lung injury, atherosclerosis, and hepatic ischemia/reperfusion—the molecule functions as a negative guidance cue for inflammatory cell trafficking and facilitates both the resolution of inflammation and tissue protection."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the realm of cancer biology, netrin‐1 acts as a key survival and pro‐tumorigenic factor. By engaging its dependence receptors (DCC and UNC5 homologs), netrin‐1 can inhibit apoptotic signals and thereby promote the survival, proliferation, and migration of malignant cells. Overexpression of netrin‐1 has been documented in a wide range of human tumors—including colorectal, breast, lung, neuroblastoma, glioblastoma, melanoma, medulloblastoma, and hepatocellular carcinoma—and its autocrine/paracrine actions support cancer cell invasion, angiogenesis, and even the maintenance of cancer stemness. Importantly, strategies that interfere with netrin‐1 signaling (such as neutralizing antibodies or combination with chemotherapeutic agents) have demonstrated therapeutic promise by provoking tumor cell death and reducing metastatic spread."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional functions of netrin‐1 extend to the regulation of tissue architecture, cell adhesion, and metabolic homeostasis. In developing epithelial organs such as the pancreas, netrin‐1 interacts with integrins to modulate cell adhesion and progenitor cell migration. It is also emerging as a key regulator of bone remodeling by promoting osteoclast differentiation, and its release into biological fluids following acute injury has highlighted its utility as a biomarker for organ damage (for example, in acute kidney injury). Moreover, netrin‐1 can protect mesenchymal stem cells under hypoxic stress and has been implicated in the induction of epithelial‐mesenchymal transition in hepatocellular carcinoma, broadening its relevance as both a mediator of tissue repair and a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "33", "end_ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "DanaKai Bradford, Stacey J Cole, Helen M Cooper "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1: diversity in development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2008.03.014"}], "href": "https://doi.org/10.1016/j.biocel.2008.03.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18455953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18455953"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "P Mehlen, C Furne "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-005-5191-3"}], "href": "https://doi.org/10.1007/s00018-005-5191-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16158190"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16158190"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zoltán Hérincs, Véronique Corset, Nathalie Cahuzac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DCC association with lipid rafts is required for netrin-1-mediated axon guidance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.02296"}], "href": "https://doi.org/10.1242/jcs.02296"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15811950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15811950"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jennifer S Goldman, Mohammed A Ashour, Margaret H Magdesian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 promotes excitatory synaptogenesis between cortical neurons by initiating synapse assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.1085-13.2013"}], "href": "https://doi.org/10.1523/JNEUROSCI.1085-13.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24174661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24174661"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Céline Furne, Nicolas Rama, Véronique Corset, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 is a survival factor during commissural neuron navigation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0803645105"}], "href": "https://doi.org/10.1073/pnas.0803645105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18796601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18796601"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Anish A Purohit, Weiquan Li, Chao Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.340174"}], "href": "https://doi.org/10.1074/jbc.M112.340174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22685302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22685302"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Aurélie Méneret, Elizabeth A Franz, Oriane Trouillard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the netrin-1 gene cause congenital mirror movements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI95442"}], "href": "https://doi.org/10.1172/JCI95442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28945198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28945198"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sangmok Kim, Kelsey C Martin "}, {"type": "b", "children": [{"type": "t", "text": "Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.04158"}], "href": "https://doi.org/10.7554/eLife.04158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25569157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25569157"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Tae-Hong Kim, Hyun Kyoung Lee, In Ae Seo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2005.03314.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2005.03314.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16181408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16181408"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Peter Rosenberger, Jan M Schwab, Valbona Mirakaj, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.1683"}], "href": "https://doi.org/10.1038/ni.1683"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19122655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19122655"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ngoc P Ly, Katsumi Komatsuzaki, Iain P Fraser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 inhibits leukocyte migration in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0506233102"}], "href": "https://doi.org/10.1073/pnas.0506233102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16203981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16203981"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Valbona Mirakaj, Cyril A Thix, Stefanie Laucher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 dampens pulmonary inflammation during acute lung injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Crit Care Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1164/rccm.200905-0717OC"}], "href": "https://doi.org/10.1164/rccm.200905-0717OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20075388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20075388"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Cornelia Podjaski, Jorge I Alvarez, Lyne Bourbonniere, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin 1 regulates blood-brain barrier function and neuroinflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awv092"}], "href": "https://doi.org/10.1093/brain/awv092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25903786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25903786"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Janine M van Gils, Merran C Derby, Luciana R Fernandes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.2205"}], "href": "https://doi.org/10.1038/ni.2205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22231519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22231519"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Bhama Ramkhelawon, Elizabeth J Hennessy, Mickaël Ménager, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.3467"}], "href": "https://doi.org/10.1038/nm.3467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24584118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24584118"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Tarik Hadi, Ludovic Boytard, Michele Silvestro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-07495-1"}], "href": "https://doi.org/10.1038/s41467-018-07495-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30479344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30479344"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Martin Schlegel, David Köhler, Andreas Körner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The neuroimmune guidance cue netrin-1 controls resolution programs and promotes liver regeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.28347"}], "href": "https://doi.org/10.1002/hep.28347"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26573873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26573873"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Khalil Miloudi, François Binet, Ariel Wilson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Truncated netrin-1 contributes to pathological vascular permeability in diabetic retinopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI84767"}], "href": "https://doi.org/10.1172/JCI84767"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27400127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27400127"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ying Xing, Jingbo Lai, Xiangyang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 restores cell injury and impaired angiogenesis in vascular endothelial cells upon high glucose by PI3K/AKT-eNOS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JME-16-0239"}], "href": "https://doi.org/10.1530/JME-16-0239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28250059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28250059"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hirofumi Arakawa "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 and its receptors in tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Cancer (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nrc1504"}], "href": "https://doi.org/10.1038/nrc1504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15573119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15573119"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Julien Fitamant, Céline Guenebeaud, Marie-May Coissieux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0709810105"}], "href": "https://doi.org/10.1073/pnas.0709810105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18353983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18353983"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Céline Delloye-Bourgeois, Elisabeth Brambilla, Marie-May Coissieux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interference with netrin-1 and tumor cell death in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/djn491"}], "href": "https://doi.org/10.1093/jnci/djn491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19211441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19211441"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Céline Delloye-Bourgeois, Julien Fitamant, Andrea Paradisi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 acts as a survival factor for aggressive neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20082299"}], "href": "https://doi.org/10.1084/jem.20082299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19349462"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19349462"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Mélodie Grandin, Markus Meier, Jean Guy Delcros, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2016.01.001"}], "href": "https://doi.org/10.1016/j.ccell.2016.01.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26859457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26859457"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Akio Shimizu, Hironao Nakayama, Priscilla Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.397398"}], "href": "https://doi.org/10.1074/jbc.M112.397398"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23195957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23195957"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Ganesan Ramesh, Arthur Berg, Calpurnia Jayakumar "}, {"type": "b", "children": [{"type": "t", "text": "Plasma netrin-1 is a diagnostic biomarker of human cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomarkers (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/1354750X.2010.541564"}], "href": "https://doi.org/10.3109/1354750X.2010.541564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21303223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21303223"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Andrea Paradisi, Marion Creveaux, Benjamin Gibert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combining chemotherapeutic agents and netrin-1 interference potentiates cancer cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/emmm.201302654"}], "href": "https://doi.org/10.1002/emmm.201302654"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24293316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24293316"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Qi Qi, Dean Y Li, Hongbo R Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1505917112"}], "href": "https://doi.org/10.1073/pnas.1505917112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26039999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26039999"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Catalina P Prieto, María Carolina Ortiz, Andrea Villanueva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 acts as a non-canonical angiogenic factor produced by human Wharton's jelly mesenchymal stem cells (WJ-MSC)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Res Ther (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13287-017-0494-5"}], "href": "https://doi.org/10.1186/s13287-017-0494-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28241866"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28241866"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Umut Kefeli, Aysegul Ucuncu Kefeli, Devrim Cabuk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 in cancer: Potential biomarker and therapeutic target?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428317698388"}], "href": "https://doi.org/10.1177/1010428317698388"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28443497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28443497"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Céline Delloye-Bourgeois, David Goldschneider, Andrea Paradisi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleolar localization of a netrin-1 isoform enhances tumor cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2002456"}], "href": "https://doi.org/10.1126/scisignal.2002456"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22871610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22871610"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Pei-Ju Sung, Nicolas Rama, Jeromine Imbach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cancer-Associated Fibroblasts Produce Netrin-1 to Control Cancer Cell Plasticity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-18-2952"}], "href": "https://doi.org/10.1158/0008-5472.CAN-18-2952"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31088838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31088838"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Mayra Yebra, Anthony M P Montgomery, Giuseppe R Diaferia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1534-5807(03)00330-7"}], "href": "https://doi.org/10.1016/s1534-5807(03"}, {"type": "t", "text": "00330-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14602071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14602071"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Aránzazu Mediero, Bhama Ramkhelawon, Miguel Perez-Aso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.2421"}], "href": "https://doi.org/10.1002/jbmr.2421"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25483983"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25483983"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Ganesan Ramesh, Catherine D Krawczeski, Jessica G Woo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urinary netrin-1 is an early predictive biomarker of acute kidney injury after cardiac surgery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin J Am Soc Nephrol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2215/CJN.05140709"}], "href": "https://doi.org/10.2215/CJN.05140709"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20007677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20007677"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Yuexing Tu, Hui Wang, Renhua Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urinary netrin-1 and KIM-1 as early biomarkers for septic acute kidney injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ren Fail (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/0886022X.2014.949764"}], "href": "https://doi.org/10.3109/0886022X.2014.949764"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25154466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25154466"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "T W Son, S P Yun, M S Yong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin α6β4-dependent Akt, GSK-3β, and HSF-1 in mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2013.94"}], "href": "https://doi.org/10.1038/cddis.2013.94"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23538444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23538444"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Wei Yan, Ping Han, Zhenzhen Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Netrin-1 induces epithelial-mesenchymal transition and promotes hepatocellular carcinoma invasiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-013-3016-z"}], "href": "https://doi.org/10.1007/s10620-013-3016-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24442237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24442237"}]}]}]}