NUF2 Gene

Name	NUF2, NDC80 kinetochore complex component
Description	This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNUF2 is an essential component of the evolutionarily conserved NDC80 complex that localizes to the outer kinetochore and plays a pivotal role in mitosis. Studies have shown that NUF2 is required for stable microtubule–kinetochore attachment, ensuring proper spindle formation and accurate chromosome segregation; its depletion in human cells causes prometaphase arrest with activation of the spindle checkpoint."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDetailed mechanistic studies have revealed that specific domains and post‐translational modifications of NUF2 are critical to its function. In particular, the calponin homology (CH) domain of NUF2 is important for maintaining proper kinetochore tension and for coordinating interactions with motor proteins such as CENP‐E. Moreover, structural analyses have demonstrated that proper dimerization between NUF2 and its binding partner, Hec1, and modifications such as poly‑SUMO‐2/3 chain conjugation, enhance NUF2’s ability to facilitate kinetochore recruitment of regulatory factors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its fundamental role in mitosis, NUF2 is frequently found to be overexpressed in a broad spectrum of human cancers—including colorectal, pancreatic, osteosarcoma, hepatocellular, breast, cholangiocarcinoma, ovarian, gastric, clear cell renal, thyroid carcinomas, and malignant peripheral nerve sheath tumors—correlating with increased tumor cell proliferation, resistance to apoptosis, and an overall poor prognosis. In several tumor models, silencing of NUF2 disrupts proper kinetochore function, leading to cell cycle arrest and reduced in vitro and in vivo tumorigenic potential. Moreover, upstream regulators (such as hnRNP K and FOXM1) and epigenetic mechanisms further modulate NUF2 expression, positioning it as a nodal factor that integrates cell cycle control with oncogenic signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "20"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, the body of work underscores the critical dual role of NUF2 – first, in ensuring the fidelity of chromosome segregation during cell division, and second, in driving tumor progression when aberrantly expressed. This makes NUF2 not only a key factor in the maintenance of genomic stability but also a promising prognostic biomarker and therapeutic target in cancer. Recent meta‐analyses and expression studies further reinforce the clinical significance of NUF2 dysregulation in various malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jennifer G DeLuca, Ben Moree, Jennifer M Hickey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200208159"}], "href": "https://doi.org/10.1083/jcb.200208159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12438418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12438418"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jennifer G DeLuca, Yimin Dong, Polla Hergert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e04-09-0852"}], "href": "https://doi.org/10.1091/mbc.e04-09-0852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15548592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15548592"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Claudio Ciferri, Jennifer De Luca, Silvia Monzani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M504070200"}], "href": "https://doi.org/10.1074/jbc.M504070200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15961401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15961401"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dan Liu, Xia Ding, Jian Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M609026200"}], "href": "https://doi.org/10.1074/jbc.M609026200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17535814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17535814"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lynsie J R Sundin, Geoffrey J Guimaraes, Jennifer G Deluca "}, {"type": "b", "children": [{"type": "t", "text": "The NDC80 complex proteins Nuf2 and Hec1 make distinct contributions to kinetochore-microtubule attachment in mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E10-08-0671"}], "href": "https://doi.org/10.1091/mbc.E10-08-0671"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21270439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21270439"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bryan Ngo, Chun-Mei Hu, Xuning Emily Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Complementary interhelical interactions between three buried Glu-Lys pairs within three heptad repeats are essential for Hec1-Nuf2 heterodimerization and mitotic progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.490524"}], "href": "https://doi.org/10.1074/jbc.M113.490524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24129578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24129578"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Divya Subramonian, Te-An Chen, Nicholas Paolini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Poly-SUMO-2/3 chain modification of Nuf2 facilitates CENP-E kinetochore localization and chromosome congression during mitosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384101.2021.1907509"}], "href": "https://doi.org/10.1080/15384101.2021.1907509"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33910471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33910471"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hironobu Sugimasa, Kenzui Taniue, Akiko Kurimoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterogeneous nuclear ribonucleoprotein K upregulates the kinetochore complex component NUF2 and promotes the tumorigenicity of colon cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.02.043"}], "href": "https://doi.org/10.1016/j.bbrc.2015.02.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25701787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25701787"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Peng Hu, Jianying Shangguan, Leida Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of NUF2 inhibits tumor growth and induces apoptosis by regulating lncRNA AF339813."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26045769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26045769"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "H-L Fu, L Shao "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of NUF2 inhibits proliferation of human osteosarcoma Saos-2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27049259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27049259"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yu Wang, Peng Yang Tan, Yohana Ayupriyanti Handoko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NUF2 is a valuable prognostic biomarker to predict early recurrence of hepatocellular carcinoma after surgical resection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.32134"}], "href": "https://doi.org/10.1002/ijc.32134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30653265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30653265"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wenjie Xu, Yizhen Wang, Yanan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Screening of differentially expressed genes and identification of NUF2 as a prognostic marker in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2019.4239"}], "href": "https://doi.org/10.3892/ijmm.2019.4239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31198978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31198978"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yang Deng, Jiapeng Li, Yingjie Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NUF2 Promotes Breast Cancer Development as a New Tumor Stem Cell Indicator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24044226"}], "href": "https://doi.org/10.3390/ijms24044226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36835637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36835637"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jijun Shan, Wangjie Jiang, Jiang Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NUF2 Drives Cholangiocarcinoma Progression and Migration via Inhibiting Autophagic Degradation of TFR1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.80737"}], "href": "https://doi.org/10.7150/ijbs.80737"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37056930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37056930"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Meng Ren, Hongyu Zhao, Yan Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NUF2 promotes tumorigenesis by interacting with HNRNPA2B1 via PI3K/AKT/mTOR pathway in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Ovarian Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13048-023-01101-9"}], "href": "https://doi.org/10.1186/s13048-023-01101-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36670423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36670423"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Xiaowen Zhu, Yumin Zou, Tong Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ANP32E contributes to gastric cancer progression via NUF2 upregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2022.12791"}], "href": "https://doi.org/10.3892/mmr.2022.12791"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35795988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35795988"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Baishu Zheng, Shunde Wang, Xiaoyu Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NUF2 is correlated with a poor prognosis and immune infiltration in clear cell renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Urol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12894-023-01258-x"}], "href": "https://doi.org/10.1186/s12894-023-01258-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37138262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37138262"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jiatian Lin, Xiangling Chen, Hongjian Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NUF2 Drives Clear Cell Renal Cell Carcinoma by Activating HMGA2 Transcription through KDM2A-mediated H3K36me2 Demethylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.70972"}], "href": "https://doi.org/10.7150/ijbs.70972"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35813477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35813477"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Lisha Bao, Yingying Gong, Yulu Che, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Maintenance of magnesium homeostasis by NUF2 promotes protein synthesis and anaplastic thyroid cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-024-07041-6"}], "href": "https://doi.org/10.1038/s41419-024-07041-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39242581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39242581"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Rehanguli Aimaier, Man-Hon Chung, Yihui Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXM1 promotes neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor progression in a NUF2-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41417-023-00645-8"}], "href": "https://doi.org/10.1038/s41417-023-00645-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37488294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37488294"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Xiaodan Jiang, Yan Jiang, Senbiao Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correlation of NUF2 Overexpression with Poorer Patient Survival in Multiple Cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res Treat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4143/crt.2020.466"}], "href": "https://doi.org/10.4143/crt.2020.466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33421974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33421974"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Jingbo Sun, Jiawei Chen, Zhizhi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression of NUF2 in breast cancer and its clinical significance]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2019.05.15"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2019.05.15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31140425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31140425"}]}]}]}
Synonyms	CT106, NUF2R, CDCA1
Proteins	NUF2_HUMAN
NCBI Gene ID	83540
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

NUF2 has 7,181 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for NUF2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

NUF2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NUF2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of NUF2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of NUF2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of NUF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of NUF2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of NUF2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NUF2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of NUF2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of NUF2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of NUF2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with NUF2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with NUF2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NUF2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of NUF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of NUF2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing NUF2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing NUF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing NUF2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with NUF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with NUF2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing NUF2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of NUF2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with NUF2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with NUF2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with NUF2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with NUF2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of NUF2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with NUF2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with NUF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with NUF2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with NUF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with NUF2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at NUF2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of NUF2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of NUF2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing NUF2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with NUF2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with NUF2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing NUF2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of NUF2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.