| Name | nucleoporin 214kDa |
| Description | The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNUP214 is a critical nucleoporin that forms an integral part of the nuclear pore complex (NPC) and is essential for nucleocytoplasmic transport. Structural studies have revealed that its N‐terminal beta‐propeller domain—with extensive insertions—and its flexible FG‐repeat regions contribute not only to anchoring the NPC’s cytoplasmic filaments but also to the dynamic permeability barrier that governs the exchange of macromolecules between the nucleus and the cytoplasm. Functionally, NUP214 participates in mRNA export and is required for efficient CRM1‐dependent nuclear protein export, while its post‐translational modifications under stress further modulate its interactions and transport efficacy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its transport‐related functions, NUP214 directly interacts with key signaling molecules. It binds to Smad proteins, thereby modulating TGF‑β signal transduction, and associates with the vitamin D receptor to influence ligand‐dependent gene activation. Moreover, NUP214 functions as a docking site for viral proteins; for instance, it mediates the attachment of herpes simplex virus capsids and adenoviral components during infection. Its expression is also subject to regulation by specific microRNAs, linking NUP214 homeostasis to the maintenance of genome integrity and stress‐responsive signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNUP214 is also notorious as a recurrent fusion partner in various hematological malignancies. In T-cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML), chromosomal rearrangements give rise to fusion proteins such as NUP214-ABL1, SET-NUP214, DEK-NUP214, and TAF-I/CAN. These fusions alter normal cellular signaling by engendering constitutively activated kinases, mislocalizing regulatory factors, and dysregulating homeobox (HOX) gene expression, thereby contributing to a differentiation block and leukemogenesis. Comparative studies have revealed that, despite sharing domains with other oncogenic kinases like BCR-ABL1, the NUP214 fusion proteins exhibit distinct subcellular localizations and catalytic properties that affect their downstream signal transduction and sensitivity to targeted inhibitors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies highlight that aberrations in NUP214 can affect cellular differentiation and nuclear organization. For example, the SET/CAN portion of certain fusion proteins compromises glucocorticoid receptor–mediated transcription and impairs hematopoietic differentiation, as demonstrated in experimental models. Furthermore, biallelic pathogenic variants in NUP214 have been linked to severe neurodevelopmental disorders characterized by impaired nuclear transport. In some leukemia cell models, NUP214 fusion proteins form dynamic nuclear bodies that sequester export factors and aberrantly target HOX gene clusters, further underscoring the multiplicity of functions governed by NUP214 in both normal physiology and disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "27", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sara M Paulillo, Erica M Phillips, Joachim Köser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleoporin domain topology is linked to the transport status of the nuclear pore complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2005.06.034"}], "href": "https://doi.org/10.1016/j.jmb.2005.06.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16045929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16045929"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Rafael Bernad, Dieuwke Engelsma, Helen Sanderson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M512585200"}], "href": "https://doi.org/10.1074/jbc.M512585200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16675447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16675447"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Saskia Hutten, Ralph H Kehlenbach "}, {"type": "b", "children": [{"type": "t", "text": "Nup214 is required for CRM1-dependent nuclear protein export in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00342-06"}], "href": "https://doi.org/10.1128/MCB.00342-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16943420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16943420"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Johanna Napetschnig, Günter Blobel, André Hoelz "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of the N-terminal domain of the human protooncogene Nup214/CAN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0610828104"}], "href": "https://doi.org/10.1073/pnas.0610828104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17264208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17264208"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Holger von Moeller, Claire Basquin, Elena Conti "}, {"type": "b", "children": [{"type": "t", "text": "The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1561"}], "href": "https://doi.org/10.1038/nsmb.1561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19219046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19219046"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Noah Crampton, Mohamed Kodiha, Sanhita Shrivastava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-05-0397"}], "href": "https://doi.org/10.1091/mbc.e09-05-0397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19828735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19828735"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Stephanie Roloff, Christiane Spillner, Ralph H Kehlenbach "}, {"type": "b", "children": [{"type": "t", "text": "Several phenylalanine-glycine motives in the nucleoporin Nup214 are essential for binding of the nuclear export receptor CRM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.433243"}], "href": "https://doi.org/10.1074/jbc.M112.433243"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23264634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23264634"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Lan Xu, Yibin Kang, Seda Cöl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(02)00586-5"}], "href": "https://doi.org/10.1016/s1097-2765(02"}, {"type": "t", "text": "00586-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12191473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12191473"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lan Xu, Claudio Alarcón, Seda Cöl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M307601200"}], "href": "https://doi.org/10.1074/jbc.M307601200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12917407"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12917407"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yoshiteru Miyauchi, Naoko Sakaguchi, Tomoko Okada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic nucleoporin CAN/Nup214 interacts with vitamin D receptor and modulates its function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.22101"}], "href": "https://doi.org/10.1002/jcb.22101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19229862"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19229862"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "David Pasdeloup, Danielle Blondel, Anabela L Isidro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Herpesvirus capsid association with the nuclear pore complex and viral DNA release involve the nucleoporin CAN/Nup214 and the capsid protein pUL25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02655-08"}], "href": "https://doi.org/10.1128/JVI.02655-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19386703"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19386703"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Aurélia Cassany, Jessica Ragues, Tinglu Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear import of adenovirus DNA involves direct interaction of hexon with an N-terminal domain of the nucleoporin Nup214."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02639-14"}], "href": "https://doi.org/10.1128/JVI.02639-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25410864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25410864"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sumana Bhattacharjya, Kumar Singha Roy, Abira Ganguly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-015-0299-z"}], "href": "https://doi.org/10.1186/s12943-015-0299-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25743594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25743594"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "C Graux, J Cools, C Melotte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1425"}], "href": "https://doi.org/10.1038/ng1425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15361874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15361874"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Roberto Rosati, Roberta La Starza, Gianluca Barba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cryptic chromosome 9q34 deletion generates TAF-Ialpha/CAN and TAF-Ibeta/CAN fusion transcripts in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.10538"}], "href": "https://doi.org/10.3324/haematol.10538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17296573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17296573"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Pieter Van Vlierberghe, Martine van Grotel, Joëlle Tchinda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-09-111872"}], "href": "https://doi.org/10.1182/blood-2007-09-111872"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18299449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18299449"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jill M Heidinger-Pauli, Elçin Unal, Vincent Guacci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The kleisin subunit of cohesin dictates damage-induced cohesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.06.005"}], "href": "https://doi.org/10.1016/j.molcel.2008.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18614046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18614046"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "K De Keersmaecker, M Versele, J Cools, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intrinsic differences between the catalytic properties of the oncogenic NUP214-ABL1 and BCR-ABL1 fusion protein kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2008.242"}], "href": "https://doi.org/10.1038/leu.2008.242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18784740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18784740"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "C Graux, M Stevens-Kroef, M Lafage, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterogeneous patterns of amplification of the NUP214-ABL1 fusion gene in T-cell acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2008.278"}], "href": "https://doi.org/10.1038/leu.2008.278"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18923437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18923437"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hilmar Quentmeier, Björn Schneider, Sonja Röhrs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1756-8722-2-3"}], "href": "https://doi.org/10.1186/1756-8722-2-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19166587"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19166587"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Carl Sandén, Malin Ageberg, Jessica Petersson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Forced expression of the DEK-NUP214 fusion protein promotes proliferation dependent on upregulation of mTOR."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-13-440"}], "href": "https://doi.org/10.1186/1471-2407-13-440"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24073922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24073922"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Julie Damgaard Sandahl, Eva A Coenen, Erik Forestier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "t(6;9)(p22;q34)/DEK-NUP214-rearranged pediatric myeloid leukemia: an international study of 62 patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2013.098517"}], "href": "https://doi.org/10.3324/haematol.2013.098517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24441146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24441146"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Marlies Vanden Bempt, Sofie Demeyer, Michaël Broux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cooperative Enhancer Activation by TLX1 and STAT5 Drives Development of NUP214-ABL1/TLX1-Positive T Cell Acute Lymphoblastic Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2018.07.007"}], "href": "https://doi.org/10.1016/j.ccell.2018.07.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30107177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30107177"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "M G Gao, Q Fu, Y Z Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Prognostic significance of DEK-NUP214 fusion gene in patients with acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Nei Ke Za Zhi (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn112138-20201015-00868"}], "href": "https://doi.org/10.3760/cma.j.cn112138-20201015-00868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34551474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34551474"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Jing Wang, Qian-Ru Zhan, Xiao-Xuan Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The characteristics and prognostic significance of the SET-CAN/NUP214 fusion gene in hematological malignancies: A systematic review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000029294"}], "href": "https://doi.org/10.1097/MD.0000000000029294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35905214"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35905214"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yu Jeong Choi, Young Kyu Min, Seung-Tae Lee, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "NUP214"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Rearrangements in Leukemia Patients: A Case Series From a Single Institution."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Lab Med (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3343/alm.2023.0301"}], "href": "https://doi.org/10.3343/alm.2023.0301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38145892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38145892"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "A Kandilci, E Mientjes, G Grosveld "}, {"type": "b", "children": [{"type": "t", "text": "Effects of SET and SET-CAN on the differentiation of the human promonocytic cell line U937."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.leu.2403227"}], "href": "https://doi.org/10.1038/sj.leu.2403227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14671643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14671643"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Sarah A Port, Adélia Mendes, Christina Valkova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.735340"}], "href": "https://doi.org/10.1074/jbc.M116.735340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27613868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27613868"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Hanan E Shamseldin, Nawal Makhseed, Niema Ibrahim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NUP214 deficiency causes severe encephalopathy and microcephaly in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-019-01979-w"}], "href": "https://doi.org/10.1007/s00439-019-01979-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30758658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30758658"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Boris Fichtman, Tamar Harel, Nitzan Biran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pathogenic Variants in NUP214 Cause \"Plugged\" Nuclear Pore Channels and Acute Febrile Encephalopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2019.05.003"}], "href": "https://doi.org/10.1016/j.ajhg.2019.05.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31178128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31178128"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Masahiro Oka, Sonoko Mura, Mayumi Otani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "HOX"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " clusters causing aberrant "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "HOX"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " expression in leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.46667"}], "href": "https://doi.org/10.7554/eLife.46667"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31755865"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31755865"}]}]}]}
|
| Synonyms | CAIN, D9S46E, CAN, N214 |
| Proteins | NU214_HUMAN |
| NCBI Gene ID | 8021 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
NUP214 has 8,835 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 134 datasets.
Click the + buttons to view associations for NUP214 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by NUP214 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of NUP214 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of NUP214 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NUP214 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of NUP214 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of NUP214 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of NUP214 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| Biocarta Pathways | pathways involving NUP214 protein from the Biocarta Pathways dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of NUP214 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NUP214 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NUP214 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of NUP214 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of NUP214 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of NUP214 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene Mutation Profiles | cell lines with NUP214 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with NUP214 protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with NUP214 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of NUP214 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of NUP214 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of NUP214 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| ClinVar Gene-Phenotype Associations 2025 | phenotypes associated with NUP214 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of NUP214 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NUP214 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing NUP214 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing NUP214 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing NUP214 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing NUP214 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with NUP214 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with NUP214 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of NUP214 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with NUP214 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with NUP214 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with NUP214 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores | diseases involving NUP214 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving NUP214 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with NUP214 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with NUP214 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with NUP214 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with NUP214 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with NUP214 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at NUP214 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of NUP214 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of NUP214 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing NUP214 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with NUP214 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with NUP214 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of NUP214 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with NUP214 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing NUP214 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of NUP214 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of NUP214 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of NUP214 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of NUP214 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of NUP214 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of NUP214 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding NUP214 protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving NUP214 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving NUP214 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving NUP214 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing NUP214 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by NUP214 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by NUP214 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by NUP214 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of NUP214 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of NUP214 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NUP214 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of NUP214 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with NUP214 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with NUP214 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with NUP214 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of NUP214 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of NUP214 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of NUP214 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of NUP214 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of NUP214 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HPM Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of NUP214 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset. | |
| HPO Gene-Disease Associations | phenotypes associated with NUP214 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for NUP214 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with NUP214 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for NUP214 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of NUP214 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of NUP214 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of NUP214 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEA Substrates of Kinases | kinases that phosphorylate NUP214 protein from the curated KEA Substrates of Kinases dataset. | |
| KEGG Pathways 2026 | pathways involving NUP214 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of NUP214 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of NUP214 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with NUP214 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of NUP214 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of NUP214 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of NUP214 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing NUP214 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain NUP214 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by NUP214 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting NUP214 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of NUP214 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of NUP214 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by NUP214 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of NUP214 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| NURSA Protein Complexes | protein complexs containing NUP214 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| NURSA Protein-Protein Interactions | interacting proteins for NUP214 from the NURSA Protein-Protein Interactions dataset. | |
| OMIM Gene-Disease Associations | phenotypes associated with NUP214 gene from the curated OMIM Gene-Disease Associations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for NUP214 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of NUP214 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of NUP214 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving NUP214 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving NUP214 protein from the Wikipathways PFOCR 2024 dataset. | |
| PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate NUP214 protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
| PID Pathways | pathways involving NUP214 protein from the PID Pathways dataset. | |
| ProteomicsDB Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of NUP214 protein relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset. | |
| Reactome Pathways 2014 | pathways involving NUP214 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving NUP214 protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of NUP214 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of NUP214 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of NUP214 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at NUP214 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of NUP214 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of NUP214 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of NUP214 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with NUP214 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of NUP214 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs | drug perturbations changing phosphorylation of NUP214 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset. | |
| SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands | ligand (protein) perturbations changing phosphorylation of NUP214 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of NUP214 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of NUP214 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of NUP214 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of NUP214 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of NUP214 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of NUP214 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of NUP214 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of NUP214 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with NUP214 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with NUP214 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving NUP214 protein from the WikiPathways Pathways 2024 dataset. | |
