{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNUP37, a core component of the nuclear pore complex, has emerged as a multifunctional protein with roles spanning normal developmental processes and oncogenesis. Genetic association studies have even implicated NUP37 in complex traits such as height variation in humans"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", while analyses in early embryos establish its maternal contribution to proper nuclear import of key transcriptional regulators, such as YAP1, thereby activating the YAP1-TEAD pathway critical for zygotic genome activation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the realm of cancer biology, NUP37 is consistently upregulated and functions as an oncogene in multiple tumor types. In liver cancer, it interacts with YAP to enhance YAP/TEAD signaling and is linked to poor prognostic outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Its overexpression in non‐small cell lung cancer is associated with increased cell proliferation, cell cycle progression, and resistance to apoptosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while in gastric and colorectal cancers, elevated NUP37 levels promote malignant behaviors by activating the PI3K/AKT/mTOR pathway and through modulation by upstream effectors such as DEPDC1B."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Additional studies have highlighted its potential as a novel biomarker in hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "as well as its association with clinical outcomes in glioma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, post‐translational modifications are key for sustaining high NUP37 protein levels in cancer; for instance, TRIM28-mediated SUMOylation at specific lysine residues inhibits its ubiquitination, thereby enhancing protein stability and fostering intracellular lipid synthesis in hepatocellular carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Collectively, these studies underscore the pivotal role of NUP37 in regulating nucleocytoplasmic transport, cell cycle progression, and diverse signaling pathways that drive both developmental and tumorigenic processes, making it a promising target for diagnostic and therapeutic interventions."}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jae-Jung Kim, Hae-In Lee, Taesung Park, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Nucleoporin37 may play a role in early embryo development in human and mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gaac017"}], "href": "https://doi.org/10.1093/molehr/gaac017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35583302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35583302"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jinxiao Chen, Da Wo, En Ma, et al. 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