{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed that NUTM2B plays an oncogenic role when fused with YWHAE in endometrial stromal sarcoma (ESS). In these tumors, the YWHAE-FAM22A/B fusion (with FAM22B being synonymous with NUTM2B) is associated with a high-grade round cell component characterized by large, irregular nuclei and high mitotic activity, in contrast to a coexisting bland, hormone receptor–positive spindle cell component. This distinctive biphasic morphology correlates with higher tumor stage and aggressive clinical behavior, underscoring the relevance of the fusion as a diagnostic and prognostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn infantile soft tissue tumors—including undifferentiated round cell sarcoma and primitive myxoid mesenchymal tumor of infancy—a YWHAE-NUTM2B fusion has been identified in a subset of cases. These findings, alongside the detection of recurrent BCOR internal tandem duplications in a related group of tumors, indicate that NUTM2B, when translocated with YWHAE, contributes to a distinct genetic signature. The overlapping histologic features of these tumors with clear cell sarcoma of the kidney suggest that the YWHAE-NUTM2B fusion may delineate a soft tissue counterpart to this renal malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn clear cell sarcoma of the kidney (CCSK), the t(10;17)(q22;p13) rearrangement generates a YWHAE-NUTM2B/E fusion transcript that, although detected in only a minority of cases, is associated with a younger age at diagnosis, lower tumor volumes, and the absence of stage I disease. These clinical observations, while not definitive due to the small number of fusion‐positive cases, support the hypothesis that the oncogenic activity of NUTM2B—as part of this fusion—contributes to a unique clinico‐pathologic profile in CCSK."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Cheng-Han Lee, Adrian Mariño-Enriquez, Wenbin Ou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The clinicopathologic features of YWHAE-FAM22 endometrial stromal sarcomas: a histologically high-grade and clinically aggressive tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0b013e31824a7b1a"}], "href": "https://doi.org/10.1097/PAS.0b013e31824a7b1a"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22456610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22456610"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yu-Chien Kao, Yun-Shao Sung, Lei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent BCOR Internal Tandem Duplication and YWHAE-NUTM2B Fusions in Soft Tissue Undifferentiated Round Cell Sarcoma of Infancy: Overlapping Genetic Features With Clear Cell Sarcoma of Kidney."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Surg Pathol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/PAS.0000000000000629"}], "href": "https://doi.org/10.1097/PAS.0000000000000629"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26945340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26945340"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Saskia L Gooskens, Colin Kenny, Antonio Lazaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The clinical phenotype of YWHAE-NUTM2B/E positive pediatric clear cell sarcoma of the kidney."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.22320"}], "href": "https://doi.org/10.1002/gcc.22320"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26542179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26542179"}]}]}]}