OAZ1 Gene

Name	ornithine decarboxylase antizyme 1
Description	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nOAZ1 is a central regulator of polyamine homeostasis. It binds to ornithine decarboxylase (ODC) and promotes its ubiquitin‐independent proteasomal degradation, thereby limiting polyamine synthesis. Its own synthesis is tightly autoregulated via a programmed, polyamine‐dependent +1 ribosomal frameshifting mechanism. Moreover, structural analyses have revealed that OAZ1 forms distinct complexes with ODC and with antizyme inhibitors, which helps fine‐tune cellular polyamine levels."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in polyamine metabolism, OAZ1 modulates several key cellular processes. It regulates cell cycle progression and centrosome duplication—through targeting regulators like Mps1—and influences signal transduction pathways, such as by forming complexes with Smad1/4 that induce the expression of the inhibitory Smad6 in bone morphogenetic protein signaling. OAZ1 also mediates the degradation of factors such as DNp73 and, more recently, has been shown to control the levels of EPLIN‑β to modulate cellular migration. These activities underpin its tumor suppressor functions observed in multiple contexts including oral cancer, chronic myeloid leukemia, and even in the control of cell proliferation independent of polyamines. Furthermore, studies in yeast highlight the evolutionary conservation of antizyme–mediated enzyme regulation, while refined mapping of functional domains in antizyme peptides has expanded our understanding of its binding properties."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlterations in OAZ1 expression and function have important pathophysiological ramifications. Epigenetic modifications and nutrient‐sensitive signaling pathways—including those mediated by mTOR—modulate OAZ1 levels, thereby integrating its activity within broader metabolic networks. In addition, genetic association studies have linked single nucleotide polymorphisms in the OAZ1 gene with autoimmune disorders such as systemic lupus erythematosus and with vascular smooth muscle cell proliferation. Changes in the promoter chromatin state of OAZ1 have also been observed in the brains of suicide completers, further underscoring the relevance of polyamine regulatory mechanisms in diverse disease settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S Matsufuji, T Matsufuji, Y Miyazaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (1995)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/0092-8674(95)90450-6"}], "href": "https://doi.org/10.1016/0092-8674(95"}, {"type": "t", "text": "90450-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "7813017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/7813017"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ursula Mangold, Ekkehard Leberer "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of all members of the antizyme family by antizyme inhibitor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20040547"}], "href": "https://doi.org/10.1042/BJ20040547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15355308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15355308"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kyoung Suk Choi, Young Ho Suh, Won-Ho Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2004.11.172"}], "href": "https://doi.org/10.1016/j.bbrc.2004.11.172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15670771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15670771"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hsiang-Yi Wu, Shin-Fu Chen, Ju-Yi Hsieh, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Translation efficiency affects the sequence-independent +1 ribosomal frameshifting by polyamines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvaa032"}], "href": "https://doi.org/10.1093/jb/mvaa032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32181810"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32181810"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Manching Ku, Shavonne Howard, Weihua Ni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "OAZ regulates bone morphogenetic protein signaling through Smad6 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M510004200"}], "href": "https://doi.org/10.1074/jbc.M510004200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16373339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16373339"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Takanori Tsuji, Miki Katsurano, Soichiro Ibaragi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi7000328"}], "href": "https://doi.org/10.1021/bi7000328"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17630775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17630775"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Julie Dumont, Mahmoud Zureik, Christophe Bauters, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of OAZ1 gene polymorphisms with subclinical and clinical vascular events."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arterioscler Thromb Vasc Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/ATVBAHA.107.150458"}], "href": "https://doi.org/10.1161/ATVBAHA.107.150458"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17761941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17761941"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ziv Porat, Guy Landau, Zippi Bercovich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Yeast antizyme mediates degradation of yeast ornithine decarboxylase by yeast but not by mammalian proteasome: new insights on yeast antizyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M708088200"}], "href": "https://doi.org/10.1074/jbc.M708088200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18089576"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18089576"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Iqbal Dulloo, Ganesan Gopalan, Gerry Melino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0906782107"}], "href": "https://doi.org/10.1073/pnas.0906782107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20185758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20185758"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Christopher Kasbek, Ching-Hui Yang, Harold A Fisk "}, {"type": "b", "children": [{"type": "t", "text": "Antizyme restrains centrosome amplification by regulating the accumulation of Mps1 at centrosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E10-04-0281"}], "href": "https://doi.org/10.1091/mbc.E10-04-0281"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20861309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20861309"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yen-Chin Liu, Yi-Liang Liu, Jia-Yang Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical factors governing the difference in antizyme-binding affinities between human ornithine decarboxylase and antizyme inhibitor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0019253"}], "href": "https://doi.org/10.1371/journal.pone.0019253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21552531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21552531"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ju-Yi Hsieh, Jung-Yen Yang, Chih-Li Lin, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Assay of OAZ1 mRNA levels in chronic myeloid leukemia combined with application of leukemia PCR array identified relevant gene changes affected by antizyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Haematol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000353406"}], "href": "https://doi.org/10.1159/000353406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24192781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24192781"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ramesh M Ray, Sujoy Bhattacharya, Mitul N Bavaria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antizyme (AZ) regulates intestinal cell growth independent of polyamines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Amino Acids (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00726-014-1777-0"}], "href": "https://doi.org/10.1007/s00726-014-1777-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24930035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24930035"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Xing Wang, Li Jiang "}, {"type": "b", "children": [{"type": "t", "text": "Effects of ornithine decarboxylase antizyme 1 on the proliferation and differentiation of human oral cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2014.1961"}], "href": "https://doi.org/10.3892/ijmm.2014.1961"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25318549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25318549"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dan Li, Suat Peng Neo, Jayantha Gunaratne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EPLIN-β is a novel substrate of ornithine decarboxylase antizyme 1 and mediates cellular migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.260427"}], "href": "https://doi.org/10.1242/jcs.260427"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37325974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37325974"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xue-bing Feng, Nan Shen, Wei-qiong Luo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[OAZ gene polymorphism in Chinese patients with systemic lupus erythematosus]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2004)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15476163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15476163"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Dong Liang, Xiu-qin Huang, Nan Shen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Psychiatr Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jpsychires.2012.11.016"}], "href": "https://doi.org/10.1016/j.jpsychires.2012.11.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23260169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23260169"}]}]}]}
Synonyms	OAZ, AZI
Proteins	OAZ1_HUMAN
NCBI Gene ID	4946
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

OAZ1 has 8,789 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 112 datasets.

Click the + buttons to view associations for OAZ1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

OAZ1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by OAZ1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of OAZ1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of OAZ1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of OAZ1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of OAZ1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of OAZ1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of OAZ1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of OAZ1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of OAZ1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of OAZ1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of OAZ1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of OAZ1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of OAZ1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with OAZ1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of OAZ1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of OAZ1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of OAZ1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of OAZ1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing OAZ1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing OAZ1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing OAZ1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with OAZ1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with OAZ1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with OAZ1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with OAZ1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with OAZ1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by OAZ1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with OAZ1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with OAZ1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with OAZ1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with OAZ1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with OAZ1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for OAZ1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at OAZ1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of OAZ1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of OAZ1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing OAZ1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with OAZ1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with OAZ1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of OAZ1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.