{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nHuman odorant‐binding protein OBP2A (also referred to as hOBP(IIa) or OBPIIa in several studies) is a secreted lipocalin predominantly expressed in the olfactory mucus covering the sensory epithelium. Its classical eight‐stranded β‐barrel structure forms a large hydrophobic pocket that accommodates and transports a wide diversity of odorant molecules, with a marked binding preference for aldehydes and long-chain fatty acids. Key basic residues in the binding pocket, notably Lys112, play a critical role in dictating the affinity and specificity for these ligands. Moreover, genetic polymorphisms in the OBP2A gene have been repeatedly associated with inter-individual differences in olfactory sensitivity, odor detection thresholds, and the perceived intensities of both food-related and bitter compounds, suggesting that OBP2A function may have far-reaching implications—from modulating flavor perception and eating behavior to influencing conditions such as inflammatory bowel disease and neurodegenerative disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its well‐established chemosensory role, a novel function for OBP2A has been uncovered in the context of prostate cancer. During androgen deprivation therapy, OBP2A is released from tumors in remission and acts as a molecular “trap” for survival factors such as CXCL15/IL8. This sequestration promotes androgen-independent cancer cell growth and facilitates the recruitment of myeloid-derived suppressor cells into the tumor microenvironment, thereby contributing to the emergence of castration-resistant prostate cancer. Importantly, therapeutic interventions that target OBP2A—either through its binding ligand (α-pinene) or by conjugating anticancer drugs—have shown promising potential in suppressing tumor progression and enhancing treatment efficacy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Loïc Briand, Corinne Eloit, Claude Nespoulous, et al. 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