OBSL1 Gene

HGNC Family	Immunoglobulin superfamily domain containing
Name	obscurin-like 1
Description	Cytoskeletal adaptor proteins function in linking the internal cytoskeleton of cells to the cell membrane. This gene encodes a cytoskeletal adaptor protein, which is a member of the Unc-89/obscurin family. The protein contains multiple N- and C-terminal immunoglobulin (Ig)-like domains and a central fibronectin type 3 domain. Mutations in this gene cause 3M syndrome type 2. Alternatively spliced transcript variants encoding different isoforms have been found in this gene. [provided by RefSeq, Mar 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nOBSL1 is a cytoskeletal adaptor protein that shares structural similarities with the giant muscle protein obscurin. It interacts with key sarcomeric components—including titin and myomesin—to help establish and maintain the integrity of muscle architecture. OBSL1 is expressed as multiple isoforms and localizes to critical subcellular domains such as the intercalated discs, perinuclear region, as well as the Z disks and M bands of cardiac myocytes, underscoring its role in organizing and stabilizing the cytoskeletal network in both cardiac and skeletal muscle cells. Its modular architecture, as further elucidated by high‐resolution structural studies, suggests that OBSL1 forms specific protein–protein complexes that are essential for normal sarcomere assembly and mechanical stability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its cytoskeletal role, OBSL1 is a critical regulator of mammalian growth, with mutations in OBSL1 being a major cause of 3‐M syndrome—a growth disorder characterized by significant pre‐ and postnatal growth retardation, dysmorphic features, and skeletal abnormalities. Through its interactions with other 3‐M syndrome proteins such as CUL7 and CCDC8, OBSL1 participates in a complex that is central to maintaining proper protein ubiquitination, microtubule dynamics, and centrosomal function. Moreover, OBSL1 influences the expression of growth regulatory factors—including insulin‐like growth factor binding proteins—thereby linking cytoskeletal organization with growth factor signalling. Disruption of OBSL1 function leads to reduced CUL7 levels and downstream signalling defects within the growth hormone–IGF axis, which collectively contribute to the clinical phenotype observed in 3‐M syndrome patients."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in muscle organization and growth regulation, OBSL1 has been identified as a host factor in viral infection. Specifically, it interacts with the minor capsid protein L2 of human papillomaviruses (HPV), where OBSL1 is recruited to sites at the plasma membrane in conjunction with tetraspanins, thereby facilitating viral endocytosis and successful infection of keratinocytes. This finding expands the functional repertoire of OBSL1, suggesting that its role as a cytoskeletal adaptor also influences pathogen entry processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sarah B Geisler, Dustin Robinson, Maria Hauringa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Obscurin-like 1, OBSL1, is a novel cytoskeletal protein related to obscurin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygeno.2006.12.004"}], "href": "https://doi.org/10.1016/j.ygeno.2006.12.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17289344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17289344"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Atsushi Fukuzawa, Stephan Lange, Mark Holt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactions with titin and myomesin target obscurin and obscurin-like 1 to the M-band: implications for hereditary myopathies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.028019"}], "href": "https://doi.org/10.1242/jcs.028019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18477606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18477606"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Surya V S R K Pulavarti, Yuanpeng J Huang, Kari Pederson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the Human Cancer Protein Interaction Network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Struct Funct Genomics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10969-014-9185-y"}], "href": "https://doi.org/10.1007/s10969-014-9185-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24989974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24989974"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Stefano Pernigo, Atsushi Fukuzawa, Amy E M Beedle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2016.11.015"}], "href": "https://doi.org/10.1016/j.str.2016.11.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27989621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27989621"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dan Hanson, Philip G Murray, Amit Sud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The primordial growth disorder 3-M syndrome connects ubiquitination to the cytoskeletal adaptor OBSL1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2009.04.021"}], "href": "https://doi.org/10.1016/j.ajhg.2009.04.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19481195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19481195"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Dan Hanson, Philip G Murray, James O'Sullivan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing identifies CCDC8 mutations in 3-M syndrome, suggesting that CCDC8 contributes in a pathway with CUL7 and OBSL1 to control human growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2011.05.028"}], "href": "https://doi.org/10.1016/j.ajhg.2011.05.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21737058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21737058"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dan Hanson, Philip G Murray, Graeme C M Black, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The genetics of 3-M syndrome: unravelling a potential new regulatory growth pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Horm Res Paediatr (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000334392"}], "href": "https://doi.org/10.1159/000334392"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22156540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22156540"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "D Hanson, P G Murray, T Coulson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in CUL7, OBSL1 and CCDC8 in 3-M syndrome lead to disordered growth factor signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JME-12-0034"}], "href": "https://doi.org/10.1530/JME-12-0034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23018678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23018678"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Dan Hanson, Adam Stevens, Philip G Murray, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying biological pathways that underlie primordial short stature using network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/JME-14-0029"}], "href": "https://doi.org/10.1530/JME-14-0029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24711643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24711643"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jun Yan, Feng Yan, Zhijun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The 3M complex maintains microtubule and genome integrity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2014.03.047"}], "href": "https://doi.org/10.1016/j.molcel.2014.03.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24793695"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24793695"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Melikşah Keskin, Nursel Muratoğlu Şahin, Erdal Kurnaz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Rare Cause of Short Stature: 3M Syndrome in a Patient with Novel Mutation in OBSL1 Gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Res Pediatr Endocrinol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4274/jcrpe.3238"}], "href": "https://doi.org/10.4274/jcrpe.3238"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27796265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27796265"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Pelin Ozlem Simsek-Kiper, Ekim Taskiran, Can Kosukcu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Further expanding the mutational spectrum and investigation of genotype-phenotype correlation in 3M syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.61154"}], "href": "https://doi.org/10.1002/ajmg.a.61154"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30980518"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30980518"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Prince Jacob, Katta M Girisha "}, {"type": "b", "children": [{"type": "t", "text": "Three M syndrome 2 in two Indian patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.61949"}], "href": "https://doi.org/10.1002/ajmg.a.61949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33135300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33135300"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Esra Isik, Duygu Arican, Tahir Atik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A rare cause of syndromic short stature: 3M syndrome in three families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.61989"}], "href": "https://doi.org/10.1002/ajmg.a.61989"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33258289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33258289"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Beyhan Tüysüz, Zeynep Alp Ünkar, Hande Turan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Natural history of facial and skeletal features from neonatal period to adulthood in a 3M syndrome cohort with biallelic CUL7 or OBSL1 variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2021.104346"}], "href": "https://doi.org/10.1016/j.ejmg.2021.104346"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34597859"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34597859"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Elena Wüstenhagen, Laura Hampe, Fatima Boukhallouk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Cytoskeletal Adaptor Obscurin-Like 1 Interacts with the Human Papillomavirus 16 (HPV16) Capsid Protein L2 and Is Required for HPV16 Endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01222-16"}], "href": "https://doi.org/10.1128/JVI.01222-16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27654294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27654294"}]}]}]}
Proteins	OBSL1_HUMAN
NCBI Gene ID	23363
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

OBSL1 has 8,434 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 113 datasets.

Click the + buttons to view associations for OBSL1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

OBSL1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of OBSL1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of OBSL1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of OBSL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of OBSL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of OBSL1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of OBSL1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of OBSL1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of OBSL1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of OBSL1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of OBSL1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with OBSL1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with OBSL1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of OBSL1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of OBSL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of OBSL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with OBSL1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with OBSL1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of OBSL1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of OBSL1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing OBSL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing OBSL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing OBSL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing OBSL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with OBSL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with OBSL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with OBSL1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with OBSL1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with OBSL1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of OBSL1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by OBSL1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving OBSL1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with OBSL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with OBSL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with OBSL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with OBSL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at OBSL1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of OBSL1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of OBSL1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing OBSL1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of OBSL1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.