{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nOrnithine decarboxylase 1 (ODC1) is the key enzyme that “gates” the polyamine biosynthetic pathway, a process essential for cell growth, differentiation, and gene regulation. Detailed biochemical and structural studies have revealed the unique catalytic mechanism of ODC1—including the formation of its pyridoxal‐5′‐phosphate (PLP) internal aldimine and the critical roles of active‐site residues—as well as its tightly regulated, ubiquitin‐independent proteasomal turnover mediated by its interaction with antizyme and antizyme inhibitor complexes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several human cancers the expression and/or activity of ODC1 is dramatically upregulated, which in turn fuels polyamine accumulation that supports oncogene‐driven cell proliferation and tumor survival. ODC1 overexpression has been implicated in malignancies such as colon adenomas, pancreatic and prostate cancers, neuroblastoma, medulloblastoma, hepatocellular carcinoma, and triple‐negative breast cancer. In these tumors, oncogenes including MYCN and c‐Myc drive increased ODC1 transcription, and pharmacologic inhibition by agents such as α‑difluoromethylornithine (DFMO) has shown promise in preclinical models by attenuating polyamine synthesis and blocking tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to oncogenic upregulation, a number of genetic and epigenetic mechanisms modulate ODC1 expression and activity. Single‐nucleotide polymorphisms (eg, G315A/G316A variants) in the ODC1 gene have been linked to altered enzyme expression, modified cancer risk and even differential chemopreventive responses to aspirin in colorectal neoplasia. Moreover, ODC1 protein stability is governed by its interactions with regulatory factors such as antizyme and antizyme inhibitor and is interconnected with cell‐cycle networks (for example, via reciprocal regulation with cyclin D1), underscoring its central role in controlling polyamine homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nODC1’s biological functions extend beyond tumorigenesis. In normal physiology and other disease states the enzyme influences immune‐mediated bacterial clearance (by modulating the availability of its polyamine product spermine), regulates apoptotic signaling cascades, and even impacts metabolic processes such as the vesicular release of glucose transporters in the small intestine. Furthermore, altered ODC1 activity has been associated with neurodegenerative conditions—including Alzheimer’s disease—and rare developmental syndromes marked by neurodevelopmental delay and alopecia, emphasizing its broad biomedical significance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shu-ichi Matsuzawa, Michael Cuddy, Toru Fukushima, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Critical factors governing the difference in antizyme-binding affinities between human ornithine decarboxylase and antizyme inhibitor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0019253"}], "href": "https://doi.org/10.1371/journal.pone.0019253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21552531"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21552531"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Eduardo F Oliveira, Nuno M F S A Cerqueira, Pedro A Fernandes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of formation of the internal aldimine in pyridoxal 5'-phosphate-dependent enzymes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Chem Soc (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/ja204229m"}], "href": "https://doi.org/10.1021/ja204229m"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21854048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21854048"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hsiang-Yi Wu, Shin-Fu Chen, Ju-Yi Hsieh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of antizyme-mediated regulation of polyamine homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1508187112"}], "href": "https://doi.org/10.1073/pnas.1508187112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26305948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26305948"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Maria Elena Martinez, Thomas G O'Brien, Kimberly E Fultz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1332465100"}], "href": "https://doi.org/10.1073/pnas.1332465100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12810952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12810952"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ahmad L Subhi, Baiqing Tang, Binaifer R Balsara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-04-0972"}], "href": "https://doi.org/10.1158/1078-0432.CCR-04-0972"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15534104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15534104"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Michael D Hogarty, Murray D Norris, Kimberly Davis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ODC1 is a critical determinant of MYCN oncogenesis and a therapeutic target in neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-6866"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-6866"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19047152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19047152"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Andrew J Symes, Marte Eilertsen, Michael Millar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitative analysis of BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0084295"}], "href": "https://doi.org/10.1371/journal.pone.0084295"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24386364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24386364"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Lisette P Yco, Dirk Geerts, Gabor Mocz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-015-1447-y"}], "href": "https://doi.org/10.1186/s12885-015-1447-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26093909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26093909"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Davide D'Amico, Laura Antonucci, Laura Di Magno, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Targeting ODC1 inhibits tumor growth through reduction of lipid metabolism in human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.09.002"}], "href": "https://doi.org/10.1016/j.bbrc.2016.09.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27592554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27592554"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Amita Shukla-Dave, Mireia Castillo-Martin, Ming Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ornithine Decarboxylase Is Sufficient for Prostate Tumorigenesis via Androgen Receptor Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2016.08.021"}], "href": "https://doi.org/10.1016/j.ajpath.2016.08.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27770613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27770613"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Renee C Geck, Jackson R Foley, Tracy Murray Stewart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.012376"}], "href": "https://doi.org/10.1074/jbc.RA119.012376"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32139506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32139506"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wei-cheng You, Jun-Yan Hong, Lian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-04-0311"}], "href": "https://doi.org/10.1158/1055-9965.EPI-04-0311"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15734972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15734972"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Elizabeth L R Barry, John A Baron, Shubha Bhat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ornithine decarboxylase polymorphism modification of response to aspirin treatment for colorectal adenoma prevention."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/djj398"}], "href": "https://doi.org/10.1093/jnci/djj398"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17047198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17047198"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Richard A Hubner, Kenneth R Muir, Jo-Fen Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-07-4599"}], "href": "https://doi.org/10.1158/1078-0432.CCR-07-4599"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18413818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18413818"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Wensheng Deng, Xian Jiang, Yu Mei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of ornithine decarboxylase in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1745-7270.2008.00397.x"}], "href": "https://doi.org/10.1111/j.1745-7270.2008.00397.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18330478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18330478"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Daisuke Yamamoto, Kaori Shima, Kou Matsuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2) in human oral cancer cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0012554"}], "href": "https://doi.org/10.1371/journal.pone.0012554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20838441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20838441"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Chad R Schultz, Caleb P Bupp, Surender Rajasekaran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical features of primary cells from a pediatric patient with a gain-of-function "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ODC1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " genetic mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20190294"}], "href": "https://doi.org/10.1042/BCJ20190294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31249027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31249027"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Shanshan Du, Shuai Wang, Fengyan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SKP2, positively regulated by circ_ODC1/miR-422a axis, promotes the proliferation of retinoblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.29177"}], "href": "https://doi.org/10.1002/jcb.29177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31297892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31297892"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Wei-Chung Hsieh, Pei-Chen Hsu, Ya-Fan Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of ornithine decarboxylase suppresses thapsigargin-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cells (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10059-010-0120-1"}], "href": "https://doi.org/10.1007/s10059-010-0120-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20814750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20814750"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Leyla Ozer, Serenay Elgun, Burcu Ozdemir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arginine-nitric oxide-polyamine metabolism in periodontal disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Periodontol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1902/jop.2010.100199"}], "href": "https://doi.org/10.1902/jop.2010.100199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20831369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20831369"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Koichi Inoue, Haruhito Tsutsui, Hiroyasu Akatsu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metabolic profiling of Alzheimer's disease brains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep02364"}], "href": "https://doi.org/10.1038/srep02364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23917584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23917584"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yo-Hsian Tsai, Kuan-Lian Lin, Yuan-Pin Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of ornithine decarboxylase promotes osteogenic differentiation of human bone marrow-derived mesenchymal stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2015.06.023"}], "href": "https://doi.org/10.1016/j.febslet.2015.06.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26140984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26140984"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Yen-Chin Liu, Chien-Yun Lee, Chi-Li Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4469"}], "href": "https://doi.org/10.18632/oncotarget.4469"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26172301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26172301"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Chakravarthi Chintalapati, Thorsten Keller, Thomas D Mueller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.116.104521"}], "href": "https://doi.org/10.1124/mol.116.104521"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27555600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27555600"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Lars Erichsen, Hans-Helge Seifert, Wolfgang A Schulz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Basic Hallmarks of Urothelial Cancer Unleashed in Primary Uroepithelium by Interference with the Epigenetic Master Regulator ODC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-60796-8"}], "href": "https://doi.org/10.1038/s41598-020-60796-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32123240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32123240"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Jeremy W Prokop, Caleb P Bupp, Austin Frisch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Emerging Role of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ODC1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in Neurodevelopmental Disorders and Brain Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes12040470"}], "href": "https://doi.org/10.3390/genes12040470"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33806076"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33806076"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Surender Rajasekaran, Caleb P Bupp, Mara Leimanis-Laurens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Repurposing eflornithine to treat a patient with a rare ODC1 gain-of-function variant disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.67097"}], "href": "https://doi.org/10.7554/eLife.67097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34282722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34282722"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Elizabeth A VanSickle, Julianne Michael, André S Bachmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expanding the phenotype: Four new cases and hope for treatment in Bachmann-Bupp syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.62473"}], "href": "https://doi.org/10.1002/ajmg.a.62473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34477286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34477286"}]}]}]}