{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nO‑GlcNAc transferase (OGT) is a multifaceted enzyme that catalyzes the addition of N‑acetylglucosamine to serine and threonine residues on numerous intracellular proteins. Structural and mechanistic studies have revealed that OGT adopts a fold comprising tandem tetratricopeptide repeats and two Rossmann‐like domains that form a superhelical groove for substrate binding. High‐resolution crystallographic snapshots and kinetic analyses have uncovered unique features of the enzyme’s donor recognition and peptide substrate specificity, establishing the basis for its catalytic mechanism and providing insight into how subtle changes in the active site can impact overall activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn response to metabolic cues, OGT functions as a nutrient sensor that integrates glucose availability and hexosamine flux into widespread post‑translational modifications. Under conditions such as glucose deprivation, increased OGT mRNA and protein levels drive an elevation in global O‑GlcNAcylation, thereby linking cellular energy status to diverse signaling cascades. Reviews of these phenomena further underscore OGT’s role in coupling nutrient status to key regulatory processes in normal physiology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its metabolic sensing role, OGT critically modulates epigenetic and cell cycle regulatory networks. OGT directly interacts with the ten‐eleven translocation (TET) family of dioxygenases, promoting histone O‑GlcNAcylation and thereby influencing chromatin structure and gene transcription. In addition, its capacity to proteolytically process host cell factor‑1 (HCF‑1) and to coordinate with mitotic kinases underscores its involvement in proper cell division and chromosomal segregation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, aberrant OGT expression and activity have been linked to oncogenic signaling and metabolic reprogramming. In prostate and other cancers, increased OGT expression stabilizes key oncogenic factors such as c‑Myc and FoxM1 and augments pro‑tumorigenic pathways including the pentose phosphate pathway via glycosylation of enzymes like glucose‑6‑phosphate dehydrogenase. Moreover, OGT is integrated into Polycomb repressive complexes, further impacting gene silencing programs during tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOGT also regulates key stress response pathways, including autophagy, through modification of factors such as the SNARE protein SNAP‑29, thereby promoting autophagic flux during nutrient deprivation. In parallel, O‑GlcNAcylation of regulatory proteins like KEAP1 modulates the stability of the transcription factor NRF2, linking OGT activity to redox homeostasis. These alterations have implications for chemoresistance in cancers, as diminished OGT expression correlates with altered autophagy and drug responsiveness."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "22", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, emerging evidence underscores the importance of OGT in neurodevelopment and placental function. Variations in placental OGT levels have been linked to maternal stress and sex‑biased outcomes in neurodevelopmental disorders, while mutations in the OGT gene itself are associated with X‑linked intellectual disability. These findings highlight OGT’s broader significance in developmental programming and disease predisposition."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "27", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carlos Martinez-Fleites, Matthew S Macauley, Yuan He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of an O-GlcNAc transferase homolog provides insight into intracellular glycosylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1443"}], "href": "https://doi.org/10.1038/nsmb.1443"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18536723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18536723"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michael B Lazarus, Yunsun Nam, Jiaoyang Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of human O-GlcNAc transferase and its complex with a peptide substrate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09638"}], "href": "https://doi.org/10.1038/nature09638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21240259"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21240259"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "David L Shen, Tracey M Gloster, Scott A Yuzwa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insights into O-linked N-acetylglucosamine ([0-9]O-GlcNAc) processing and dynamics through kinetic analysis of O-GlcNAc transferase and O-GlcNAcase activity on protein substrates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.310664"}], "href": "https://doi.org/10.1074/jbc.M111.310664"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22311971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22311971"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michael B Lazarus, Jiaoyang Jiang, Tracey M Gloster, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural snapshots of the reaction coordinate for O-GlcNAc transferase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Chem Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nchembio.1109"}], "href": "https://doi.org/10.1038/nchembio.1109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23103939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23103939"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Marianne Schimpl, Xiaowei Zheng, Vladimir S Borodkin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Chem Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nchembio.1108"}], "href": "https://doi.org/10.1038/nchembio.1108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23103942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23103942"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Shalini Pathak, Jana Alonso, Marianne Schimpl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The active site of O-GlcNAc transferase imposes constraints on substrate sequence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.3063"}], "href": "https://doi.org/10.1038/nsmb.3063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26237509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26237509"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Donald A McClain, William A Lubas, Robert C Cooksey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.152346899"}], "href": "https://doi.org/10.1073/pnas.152346899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12136128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12136128"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rodrick P Taylor, Glendon J Parker, Mark W Hazel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M707328200"}], "href": "https://doi.org/10.1074/jbc.M707328200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18174169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18174169"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Michelle R Bond, John A Hanover "}, {"type": "b", "children": [{"type": "t", "text": "O-GlcNAc cycling: a link between metabolism and chronic disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Annu Rev Nutr (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1146/annurev-nutr-071812-161240"}], "href": "https://doi.org/10.1146/annurev-nutr-071812-161240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23642195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23642195"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Lewis J Watson, Heberty T Facundo, Gladys A Ngoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "O-linked β-N-acetylglucosamine transferase is indispensable in the failing heart."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1001907107"}], "href": "https://doi.org/10.1073/pnas.1001907107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20876116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20876116"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Qiang Chen, Yibin Chen, Chunjing Bian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TET2 promotes histone O-GlcNAcylation during gene transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature11742"}], "href": "https://doi.org/10.1038/nature11742"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23222540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23222540"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Michael B Lazarus, Jiaoyang Jiang, Vaibhav Kapuria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HCF-1 is cleaved in the active site of O-GlcNAc transferase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1243990"}], "href": "https://doi.org/10.1126/science.1243990"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24311690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24311690"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Zebulon G Levine, Suzanne Walker "}, {"type": "b", "children": [{"type": "t", "text": "The Biochemistry of O-GlcNAc Transferase: Which Functions Make It Essential in Mammalian Cells?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Annu Rev Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1146/annurev-biochem-060713-035344"}], "href": "https://doi.org/10.1146/annurev-biochem-060713-035344"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27294441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27294441"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Kaoru Sakabe, Gerald W Hart "}, {"type": "b", "children": [{"type": "t", "text": "O-GlcNAc transferase regulates mitotic chromatin dynamics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.158170"}], "href": "https://doi.org/10.1074/jbc.M110.158170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20805223"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20805223"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Chad Slawson, T Lakshmanan, Spencer Knapp, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e07-11-1146"}], "href": "https://doi.org/10.1091/mbc.e07-11-1146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18653473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18653473"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Anna Krześlak, Ewa Forma, Magdalena Bernaciak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression of O-GlcNAc cycling enzymes in human breast cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10238-011-0138-5"}], "href": "https://doi.org/10.1007/s10238-011-0138-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21567137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21567137"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Harri M Itkonen, Sarah Minner, Ingrid J Guldvik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "O-GlcNAc transferase integrates metabolic pathways to regulate the stability of c-MYC in human prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-13-0549"}], "href": "https://doi.org/10.1158/0008-5472.CAN-13-0549"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23720054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23720054"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiongjian Rao, Xiaotao Duan, Weimin Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms9468"}], "href": "https://doi.org/10.1038/ncomms9468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26399441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26399441"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Stefan Burén, Ana L Gomes, Ana Teijeiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2016.06.023"}], "href": "https://doi.org/10.1016/j.ccell.2016.06.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27505673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27505673"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Simon Hauri, Federico Comoglio, Makiko Seimiya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A High-Density Map for Navigating the Human Polycomb Complexome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.08.096"}], "href": "https://doi.org/10.1016/j.celrep.2016.08.096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27705803"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27705803"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Weiqi Xu, Xiang Zhang, Jian-Lin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2017.03.017"}], "href": "https://doi.org/10.1016/j.jhep.2017.03.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28347804"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28347804"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Zahra Kazemi, Hana Chang, Sarah Haserodt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "O-linked beta-N-acetylglucosamine (O-GlcNAc) regulates stress-induced heat shock protein expression in a GSK-3beta-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.131102"}], "href": "https://doi.org/10.1074/jbc.M110.131102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20926391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20926391"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Bin Guo, Qianqian Liang, Lin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3066"}], "href": "https://doi.org/10.1038/ncb3066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25419848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25419848"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Po-Han Chen, Timothy J Smith, Jianli Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glycosylation of KEAP1 links nutrient sensing to redox stress signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201696113"}], "href": "https://doi.org/10.15252/embj.201696113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28663241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28663241"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Tianliang Li, Xinghui Li, Kuldeep S Attri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2018.11.001"}], "href": "https://doi.org/10.1016/j.chom.2018.11.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30543776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30543776"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Fuxing Zhou, Xiaoshan Yang, Hang Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.27806"}], "href": "https://doi.org/10.7150/thno.27806"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30555541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30555541"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Christopher L Howerton, Christopher P Morgan, David B Fischer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "O-GlcNAc transferase (OGT) as a placental biomarker of maternal stress and reprogramming of CNS gene transcription in development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1300065110"}], "href": "https://doi.org/10.1073/pnas.1300065110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23487789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23487789"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Krithika Vaidyanathan, Tejasvi Niranjan, Nithya Selvan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of a missense mutation in the "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "O"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-linked β-"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "N"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-acetylglucosamine ("}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "O"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-GlcNAc) transferase gene that segregates with X-linked intellectual disability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.771030"}], "href": "https://doi.org/10.1074/jbc.M116.771030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28302723"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28302723"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Bridget M Nugent, Carly M O'Donnell, C Neill Epperson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Placental H3K27me3 establishes female resilience to prenatal insults."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-04992-1"}], "href": "https://doi.org/10.1038/s41467-018-04992-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29967448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29967448"}]}]}]}