| Name | oocyte secreted protein 1, pseudogene |
| Description | Predicted to act upstream of or within blastocyst development. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVGLL3, a transcriptional cofactor, exerts diverse roles early in development and lineage commitment. In embryonic and fetal stages, a VGLL3 homolog (VITO‑2) is expressed in the myogenic lineage, where it collaborates with TEF proteins to promote muscle differentiation, while its dynamic regulation also influences mesenchymal cell fate by inhibiting adipogenesis. Indeed, lower VGLL3 levels favor adipocyte maturation, and in differentiated myoblasts, elevated VGLL3 can promote the slow‑twitch fiber program via induction of PGC‑1α."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of immune regulation and oncogenesis, aberrant VGLL3 activity has striking consequences. Overexpression of VGLL3 in the skin drives a proinflammatory gene program that mimics lupus‐like autoimmunity, characterized by B cell expansion and autoantibody production. By contrast, loss or significant reduction of VGLL3 expression in high‑grade serous ovarian carcinomas implicates it in tumor suppressor pathways, suggesting that its normal levels may be critical in maintaining balanced cellular growth and preventing malignant transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nVGLL3 also emerges as a key mediator in tissue remodeling processes. In fibrotic hearts, substrate stiffness promotes the nuclear translocation of VGLL3 via an integrin–Rho–actin pathway, where it forms condensates with RNA‑binding proteins to suppress microRNAs that target collagen mRNAs, thereby enhancing myofibroblast collagen production. Moreover, in osteoblasts, VGLL3 facilitates bone formation by supporting BMP signaling and the expression of osteogenic transcription factors, underlining its essential role in skeletal differentiation and maintenance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Michal Mielcarek, Izabela Piotrowska, Andre Schneider, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VITO-2, a new SID domain protein, is expressed in the myogenic lineage during early mouse embryonic development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene Expr Patterns (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gep.2008.12.002"}], "href": "https://doi.org/10.1016/j.gep.2008.12.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19118645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19118645"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniel S Halperin, Calvin Pan, Aldons J Lusis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vestigial-like 3 is an inhibitor of adipocyte differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M032755"}], "href": "https://doi.org/10.1194/jlr.M032755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23152581"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23152581"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yuki Takakura, Takayuki Suzuki, Naoto Hirai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VGLL3 confers slow-twitch muscle differentiation via PGC-1α expression in C2C12 myocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2023.05.073"}], "href": "https://doi.org/10.1016/j.bbrc.2023.05.073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37262950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37262950"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Karen Gambaro, Michael C J Quinn, Paulina M Wojnarowicz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molonc.2012.12.006"}], "href": "https://doi.org/10.1016/j.molonc.2012.12.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23415753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23415753"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Allison C Billi, Mehrnaz Gharaee-Kermani, Joseph Fullmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The female-biased factor VGLL3 drives cutaneous and systemic autoimmunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.127291"}], "href": "https://doi.org/10.1172/jci.insight.127291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30996136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30996136"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Haoze Yuan, Mika Ikegame, Yoko Fukuhara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vestigial-Like 3 Plays an Important Role in Osteoblast Differentiation by Regulating the Expression of Osteogenic Transcription Factors and BMP Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Calcif Tissue Int (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00223-022-00997-7"}], "href": "https://doi.org/10.1007/s00223-022-00997-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35750933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35750933"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yuma Horii, Shoichi Matsuda, Chikashi Toyota, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-023-36189-6"}], "href": "https://doi.org/10.1038/s41467-023-36189-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36754961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36754961"}]}]}]}
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| Proteins | OOSP1_HUMAN |
| NCBI Gene ID | 255649 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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OOSP1 has 1,314 functional associations with biological entities spanning 6 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 32 datasets.
Click the + buttons to view associations for OOSP1 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of OOSP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of OOSP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with OOSP1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OOSP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of OOSP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of OOSP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of OOSP1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing OOSP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with OOSP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with OOSP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with OOSP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with OOSP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at OOSP1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of OOSP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of OOSP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing OOSP1 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of OOSP1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of OOSP1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of OOSP1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of OOSP1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of OOSP1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of OOSP1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of OOSP1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain OOSP1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by OOSP1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| NURSA Protein Complexes | protein complexs containing OOSP1 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of OOSP1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of OOSP1 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of OOSP1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of OOSP1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with OOSP1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with OOSP1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
