{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA survey of the provided abstracts reveals a comprehensive body of work focused on vitamin D metabolism and its regulatory network—including studies on fibroblast growth factor‐23, parathyroid hormone, calcitonin, and the enzymatic conversion of vitamin D by CYP27B1 in diverse tissues such as the kidney, bone, skin, skeletal muscle, and immune cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nConversely, none of the abstracts mention or address OR5P2—a gene typically categorized among olfactory receptors or with unknown function in non‐olfactory tissues—despite detailing intricate mechanisms of vitamin D activation and response. Several reports elucidate the control of 1α‐hydroxylase expression and its downstream effects in disease models and normal physiology; however, they do not include any reference to OR5P2 or suggest any role for it in these vitamin D–related pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the assembled studies significantly advance our understanding of vitamin D signaling and its multifaceted roles—including its influence on mineral homeostasis, skeletal development, immune modulation, and extra‐renal vitamin D activation—none offer any insight into the function of OR5P2. The absence of OR5P2 in these investigations highlights a gap in the literature, suggesting that targeted research will be necessary to determine whether OR5P2 plays any ancillary or regulatory role in these or other biological processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nasreen Azam, Martin Y H Zhang, Xuemei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disordered regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase gene expression by phosphorus in X-linked hypophosphatemic (hyp) mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2003-0255"}], "href": "https://doi.org/10.1210/en.2003-0255"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12865326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12865326"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ayako Matsunuma, Tetsuya Kawane, Toyonobu Maeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leptin corrects increased gene expression of renal 25-hydroxyvitamin D3-1 alpha-hydroxylase and -24-hydroxylase in leptin-deficient, ob/ob mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2003-1010"}], "href": "https://doi.org/10.1210/en.2003-1010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14657008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14657008"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Joost G J Hoenderop, Helena Chon, Dimitra Gkika, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of gene expression by dietary Ca2+ in kidneys of 25-hydroxyvitamin D3-1 alpha-hydroxylase knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kidney Int (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1523-1755.2004.00402.x"}], "href": "https://doi.org/10.1111/j.1523-1755.2004.00402.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14717923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14717923"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "D D Bikle, S Chang, D Crumrine, et al. "}, {"type": "b", "children": [{"type": "t", "text": "25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.0022-202X.2004.22424.x"}], "href": "https://doi.org/10.1111/j.0022-202X.2004.22424.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15102089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15102089"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Keiko Yamamoto, Eriko Uchida, Naoko Urushino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D3 whose mutation causes vitamin D-dependent rickets type 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M505244200"}], "href": "https://doi.org/10.1074/jbc.M505244200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15972816"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15972816"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Janeen L Vanhooke, Jean M Prahl, Christine Kimmel-Jehan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CYP27B1 null mice with LacZreporter gene display no 25-hydroxyvitamin D3-1alpha-hydroxylase promoter activity in the skin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0509734103"}], "href": "https://doi.org/10.1073/pnas.0509734103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16371465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16371465"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "K Stoffels, L Overbergh, R Bouillon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immune regulation of 1alpha-hydroxylase in murine peritoneal macrophages: unravelling the IFNgamma pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsbmb.2006.12.091"}], "href": "https://doi.org/10.1016/j.jsbmb.2006.12.091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17267208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17267208"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Farzana Perwad, Martin Y H Zhang, Harriet S Tenenhouse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fibroblast growth factor 23 impairs phosphorus and vitamin D metabolism in vivo and suppresses 25-hydroxyvitamin D-1alpha-hydroxylase expression in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00463.2006"}], "href": "https://doi.org/10.1152/ajprenal.00463.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17699549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17699549"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Matthew J Rowling, Christy Gliniak, JoEllen Welsh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Nutr (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jn/137.12.2608"}], "href": "https://doi.org/10.1093/jn/137.12.2608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18029472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18029472"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Nancy Liu, Lisa Nguyen, Rene F Chun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2008-0060"}], "href": "https://doi.org/10.1210/en.2008-0060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18535110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18535110"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jia Li, Mary E Byrne, Eugene Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsbmb.2008.09.006"}], "href": "https://doi.org/10.1016/j.jsbmb.2008.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18840526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18840526"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yan Zhong, Harvey J Armbrecht, Sylvia Christakos "}, {"type": "b", "children": [{"type": "t", "text": "Calcitonin, a regulator of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M806561200"}], "href": "https://doi.org/10.1074/jbc.M806561200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19261615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19261615"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Roy Pascal Naja, Olivier Dardenne, Alice Arabian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chondrocyte-specific modulation of Cyp27b1 expression supports a role for local synthesis of 1,25-dihydroxyvitamin D3 in growth plate development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2008-1410"}], "href": "https://doi.org/10.1210/en.2008-1410"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19477943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19477943"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yanping Wang, Steven J Marling, Jinge G Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Development of experimental autoimmune encephalomyelitis (EAE) in mice requires vitamin D and the vitamin D receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1206054109"}], "href": "https://doi.org/10.1073/pnas.1206054109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22592802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22592802"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ratchakrit Srikuea, Xiping Zhang, Ok-Kyong Park-Sarge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VDR and CYP27B1 are expressed in C2C12 cells and regenerating skeletal muscle: potential role in suppression of myoblast proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00014.2012"}], "href": "https://doi.org/10.1152/ajpcell.00014.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22648952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22648952"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ankanee Chanakul, Martin Y H Zhang, Andrew Louw, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0072816"}], "href": "https://doi.org/10.1371/journal.pone.0072816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24019880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24019880"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Daniel C Reinke, Masakazu Kogawa, Kate R Barratt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for altered osteoclastogenesis in splenocyte cultures from Cyp27b1 knockout mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsbmb.2015.11.015"}], "href": "https://doi.org/10.1016/j.jsbmb.2015.11.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26639637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26639637"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Noelia Torremadé, Milica Bozic, Sara Panizo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1α-Hydroxylase Expression in Vascular Smooth Muscle Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.2852"}], "href": "https://doi.org/10.1002/jbmr.2852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27074284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27074284"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jiarong Li, Aimée-Lee Luco, Benoît Ochietti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumoral Vitamin D Synthesis by CYP27B1 1-α-Hydroxylase Delays Mammary Tumor Progression in the PyMT-MMTV Mouse Model and Its Action Involves NF-κB Modulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2015-1824"}], "href": "https://doi.org/10.1210/en.2015-1824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27119753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27119753"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Wei Xiang, Wang Liao, Zhuwen Yi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "25-Hydroxyvitamin D-1-α-hydroxylase in apoliporotein E knockout mice: The role of protecting vascular smooth muscle cell from calcification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.01.093"}], "href": "https://doi.org/10.1016/j.biopha.2017.01.093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28178628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28178628"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Brittany R Gillies, Brittany A Ryan, Brett A Tonkin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Absence of Calcitriol Causes Increased Lactational Bone Loss and Lower Milk Calcium but Does Not Impair Post-lactation Bone Recovery in Cyp27b1 Null Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbmr.3217"}], "href": "https://doi.org/10.1002/jbmr.3217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28686309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28686309"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Mark B Meyer, Nancy A Benkusky, Martin Kaufmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A kidney-specific genetic control module in mice governs endocrine regulation of the cytochrome P450 gene "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Cyp27b1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " essential for vitamin D"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "3"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M117.806901"}], "href": "https://doi.org/10.1074/jbc.M117.806901"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28808057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28808057"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Rajesh Parsanathan, Sushil K Jain "}, {"type": "b", "children": [{"type": "t", "text": "Glutathione deficiency alters the vitamin D-metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD-fed mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Free Radic Biol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.freeradbiomed.2018.12.017"}], "href": "https://doi.org/10.1016/j.freeradbiomed.2018.12.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30578920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30578920"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yu Fu, Jiajun Zhu, Yalin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vitamin D Regulates the Expressions of AQP-1 and AQP-4 in Mice Kidneys."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/3027036"}], "href": "https://doi.org/10.1155/2019/3027036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30809535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30809535"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Loan Nguyen-Yamamoto, Ken-Ichiro Tanaka, Rene St-Arnaud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vitamin D-regulated osteocytic sclerostin and BMP2 modulate uremic extraskeletal calcification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.126467"}], "href": "https://doi.org/10.1172/jci.insight.126467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31292298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31292298"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Takahiro Kikuyama, Takao Susa, Mimi Tamamori-Adachi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "25(OH)D"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "3"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " stimulates the expression of vitamin D target genes in renal tubular cells when Cyp27b1 is abrogated."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsbmb.2020.105593"}], "href": "https://doi.org/10.1016/j.jsbmb.2020.105593"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31945466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31945466"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Risako Mori, Takumi Yokokawa, Satoshi Fujita "}, {"type": "b", "children": [{"type": "t", "text": "Modified expression of vitamin D receptor and CYP27B1 in denervation-induced muscle atrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.05.205"}], "href": "https://doi.org/10.1016/j.bbrc.2020.05.205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32736700"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32736700"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Pengjing Lian, Yu Bai, Jingyun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vitamin D receptor and 1α-hydroxylase are highly expressed in lungs of mice infected with H9N2 avian influenza viruses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsbmb.2021.105907"}], "href": "https://doi.org/10.1016/j.jsbmb.2021.105907"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33965570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33965570"}]}]}]}