{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent advances in cancer genomics have revealed that pseudogenes, once dismissed as “junk” DNA, can play active roles in tumor biology. In particular, the olfactory receptor family 7 subfamily E member 47 pseudogene (OR7E47P) displays broad expression across lung tissues and has emerged as a positive regulator within the tumor microenvironment (TME) of lung adenocarcinoma. This unexpected function suggests that OR7E47P may modulate gene transcription through interactions with other genes, contributing to tumor initiation and progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nBuilding on its established role in lung adenocarcinoma, recent investigations have begun to probe the involvement of OR7E47P in tumor immunity, particularly within lung squamous cell carcinoma (LUSC). The study associated with abstract 1 seeks to elucidate the correlation between OR7E47P expression and the modulation of immune responses in the TME. The findings imply that, despite its classification as a pseudogene, OR7E47P might influence immune cell interactions and thus participate in shaping the local immune milieu in lung cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n\nUnderstanding the role of OR7E47P in regulating tumor immunity not only challenges traditional views of pseudogene functionality but also opens potential avenues for therapeutic intervention. By altering transcriptional networks within the TME, OR7E47P may serve as a novel biomarker or a target in strategies aimed at modulating the immune landscape to combat lung cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ya-Qi Zhao, Hao-Han Zhang, Jie Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prediction of Tumor Microenvironment Characteristics and Treatment Response in Lung Squamous Cell Carcinoma by Pseudogene OR7E47P-related Immune Genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Med Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11596-023-2798-2"}], "href": "https://doi.org/10.1007/s11596-023-2798-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38015361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38015361"}]}]}]}