OSBPL10 Gene

HGNC Family	Oxysterol binding proteins (OSBP), Pleckstrin homology domain containing (PLEKH)
Name	oxysterol binding protein-like 10
Description	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have revealed a novel role for OSBPL10 in cancer biology. In gastric cancer, for example, a highly expressed circular RNA derived from the OSBPL10 gene—termed circOSBPL10—has been shown to promote cell proliferation, migration, invasion, and metastasis. Acting as a molecular sponge for miR-136-5p, circOSBPL10 modulates the downstream WNT2 pathway and serves as a prognostic marker for both overall and disease‐free survival, underscoring its potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in tumorigenesis, OSBPL10 (also known as ORP10) is an important regulator of hepatic lipid metabolism. Functional experiments in hepatoma cell models have demonstrated that silencing OSBPL10 increases the incorporation of acetate into cholesterol and triglycerides and enhances the secretion of apolipoprotein B100, suggesting that the protein normally acts to suppress hepatic lipogenesis and very-low-density lipoprotein production. Genetic association studies further indicate that polymorphisms in OSBPL10 are linked with abnormal serum triglyceride and low-density lipoprotein levels, thereby implicating the gene in dyslipidemias and metabolic syndrome risk factors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "2", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond lipid synthesis regulation, OSBPL10 is also involved in intracellular lipid transport and membrane remodeling. It participates in lipid countertransport at endoplasmic reticulum–endosome contact sites, mediating the exchange of phosphatidylinositol-4-phosphate and phosphatidylserine—a process crucial for endosome fission and retrograde trafficking. In parallel, genetic findings have suggested that variation at the OSBPL10 locus may contribute to peripheral arterial disease, highlighting the gene’s multifaceted impact on cellular lipid homeostasis and cardiovascular health."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sen Wang, Xing Zhang, Zheng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA profile identifies circOSBPL10 as an oncogenic factor and prognostic marker in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-019-0933-0"}], "href": "https://doi.org/10.1038/s41388-019-0933-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31409903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31409903"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Julia Perttilä, Krista Merikanto, Jussi Naukkarinen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Med (Berl) (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00109-009-0490-z"}], "href": "https://doi.org/10.1007/s00109-009-0490-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19554302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19554302"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Eija Nissilä, Yuki Ohsaki, Marion Weber-Boyvat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2012.08.004"}], "href": "https://doi.org/10.1016/j.bbalip.2012.08.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22906437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22906437"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hiroshi Koriyama, Hironori Nakagami, Tomohiro Katsuya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variation in OSBPL10 is associated with dyslipidemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertens Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/hr.2010.28"}], "href": "https://doi.org/10.1038/hr.2010.28"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20224571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20224571"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Asami Kawasaki, Akiko Sakai, Hiroki Nakanishi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PI4P/PS countertransport by ORP10 at ER-endosome membrane contact sites regulates endosome fission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202103141"}], "href": "https://doi.org/10.1083/jcb.202103141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34817532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34817532"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Hiroshi Koriyama, Hironori Nakagami, Tomohiro Katsuya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Atheroscler Thromb (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5551/jat.4291"}], "href": "https://doi.org/10.5551/jat.4291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20610895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20610895"}]}]}]}
Synonyms	OSBP9, ORP10
Proteins	OSB10_HUMAN
NCBI Gene ID	114884
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

OSBPL10 has 10,199 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for OSBPL10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

OSBPL10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of OSBPL10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of OSBPL10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of OSBPL10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of OSBPL10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of OSBPL10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of OSBPL10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of OSBPL10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of OSBPL10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of OSBPL10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of OSBPL10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of OSBPL10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of OSBPL10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with OSBPL10 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with OSBPL10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of OSBPL10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of OSBPL10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of OSBPL10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of OSBPL10 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of OSBPL10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing OSBPL10 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with OSBPL10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with OSBPL10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of OSBPL10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with OSBPL10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with OSBPL10 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with OSBPL10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with OSBPL10 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by OSBPL10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with OSBPL10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with OSBPL10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with OSBPL10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with OSBPL10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at OSBPL10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of OSBPL10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of OSBPL10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing OSBPL10 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with OSBPL10 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with OSBPL10 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of OSBPL10 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with OSBPL10 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.