OSBPL1A Gene

HGNC Family	Ankyrin repeat domain containing (ANKRD), Oxysterol binding proteins (OSBP)
Name	oxysterol binding protein-like 1A
Description	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. Transcript variants derived from alternative promoter usage and/or alternative splicing exist; they encode different isoforms. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nOSBPL1A encodes the oxysterol-binding protein ORP1L, which plays a central role in sensing and transporting cholesterol within cells. ORP1L monitors the cholesterol content of late endosomal membranes and, under low-cholesterol conditions, promotes the formation of membrane contact sites between endosomes and the endoplasmic reticulum. These contacts facilitate the extraction and nonvesicular transfer of cholesterol, a process dependent on its sterol‐binding function as well as on interactions with key proteins such as VAP. This activity is further underscored by studies demonstrating that ORP1L regulates endosomal cholesterol export from late endosomes to the ER and even directs lipid flux to the plasma membrane via its truncated variant, emphasizing its multifaceted role in maintaining cellular lipid homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in cholesterol handling, ORP1L critically governs the positioning and dynamics of late endosomal compartments. It interacts directly with the small GTPase Rab7 and its effector RILP, a partnership that steers the movement of late endosomes along microtubules. Structural and biochemical analyses reveal that the interaction with Rab7 occurs via a unique region of ORP1L that leaves canonical switch regions available for additional effectors, thereby orchestrating the balance between retrograde and anterograde motor activities. Moreover, ORP1L is implicated in the regulation of autophagosome maturation and even participates in the formation of membrane contacts with mitochondria during fission, highlighting its versatile contributions to organelle dynamics."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nORP1L is also a pivotal player in host–pathogen interactions and the modulation of innate immune responses. Certain intracellular pathogens, such as Coxiella burnetii and adenovirus, subvert ORP1L functions to remodel pathogen-containing vacuoles. By co-opting ORP1L, these microbes influence cholesterol trafficking at membrane contact sites between pathogen‐housing compartments and the ER, thereby controlling vacuole positioning and the lipid composition that affects both microbial survival and host inflammatory signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDivergent isoforms generated from OSBPL1A transcripts further expand the functional repertoire of this gene. The longer variant, ORP1L, specifically localizes to late endosomes, whereas a shorter variant (ORP1S) is predominantly cytosolic and shows evidence of nuclear shuttling in response to sterol binding. Notably, the differential tissue expression and imprinting patterns—where OSBPL1A exhibits maternal allele‐biased expression in some contexts—suggest that distinct forms have specialized roles in lipid signaling and gene regulation, including the activation of liver X receptor (LXR)–mediated transcription."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, genetic studies underscore the clinical relevance of OSBPL1A in metabolic disorders. Genome-wide association and allele-specific expression analyses have identified OSBPL1A as a candidate gene implicated in osteoporosis-related traits, and rare coding variants as well as regulatory polymorphisms in this gene have been linked to altered plasma high-density lipoprotein cholesterol levels. In particular, microRNA-mediated regulation of OSBPL1A further connects its lipid transport functions to the pathogenesis of atherosclerosis, reinforcing the notion that both the full-length and truncated forms of the protein are integral for balancing cellular cholesterol distribution."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nuno Rocha, Coenraad Kuijl, Rik van der Kant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200811005"}], "href": "https://doi.org/10.1083/jcb.200811005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19564404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19564404"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Terhi Vihervaara, Riikka-Liisa Uronen, Gerd Wohlfahrt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sterol binding by OSBP-related protein 1L regulates late endosome motility and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-010-0470-z"}], "href": "https://doi.org/10.1007/s00018-010-0470-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20690035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20690035"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nicholas L Cianciola, Diane J Greene, Richard E Morton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adenovirus RIDα uncovers a novel pathway requiring ORP1L for lipid droplet formation independent of NPC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E12-10-0760"}], "href": "https://doi.org/10.1091/mbc.E12-10-0760"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24025716"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24025716"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kexin Zhao, Neale D Ridgway "}, {"type": "b", "children": [{"type": "t", "text": "Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2017.05.028"}], "href": "https://doi.org/10.1016/j.celrep.2017.05.028"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28564600"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28564600"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jiangqing Dong, Ximing Du, Huan Wang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formation and late endosome positioning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.001854"}], "href": "https://doi.org/10.1074/jbc.RA118.001854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30012887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30012887"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Maxime Boutry, Peter K Kim "}, {"type": "b", "children": [{"type": "t", "text": "ORP1L mediated PI(4)P signaling at ER-lysosome-mitochondrion three-way contact contributes to mitochondrial division."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-25621-4"}], "href": "https://doi.org/10.1038/s41467-021-25621-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34504082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34504082"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Anna V Justis, Bryan Hansen, Paul A Beare, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactions between the Coxiella burnetii parasitophorous vacuole and the endoplasmic reticulum involve the host protein ORP1L."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Microbiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cmi.12637"}], "href": "https://doi.org/10.1111/cmi.12637"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27345457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27345457"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nicholas L Cianciola, Stacey Chung, Danny Manor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01904-16"}], "href": "https://doi.org/10.1128/JVI.01904-16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28077646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28077646"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Baleigh Schuler, Margaret Sladek, Stacey D Gilk "}, {"type": "b", "children": [{"type": "t", "text": "Host Lipid Transport Protein ORP1 Is Necessary for Coxiella burnetii Growth and Vacuole Expansion in Macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "mSphere (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/msphere.00104-23"}], "href": "https://doi.org/10.1128/msphere.00104-23"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37017523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37017523"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Marie Johansson, Virginie Bocher, Markku Lehto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e02-08-0459"}], "href": "https://doi.org/10.1091/mbc.e02-08-0459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12631712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12631712"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hans T Bjornsson, Thomas J Albert, Christine M Ladd-Acosta, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000977"}], "href": "https://doi.org/10.1371/journal.pgen.1000977"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20548944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20548944"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Mahdi M Motazacker, Juho Pirhonen, Julian C van Capelleveen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Atherosclerosis (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.atherosclerosis.2016.04.005"}], "href": "https://doi.org/10.1016/j.atherosclerosis.2016.04.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27105157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27105157"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Li-Bo Chen, Hai-Kuo Zheng, Lei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A single nucleotide polymorphism located in microRNA-499a causes loss of function resulting in increased expression of osbpl1a and reduced serum HDL level."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.6016"}], "href": "https://doi.org/10.3892/or.2017.6016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29039586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29039586"}]}]}]}
Synonyms	OSBPL1B, ORP-1
Proteins	OSBL1_HUMAN
NCBI Gene ID	114876
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

OSBPL1A has 6,893 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for OSBPL1A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

OSBPL1A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of OSBPL1A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of OSBPL1A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of OSBPL1A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of OSBPL1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of OSBPL1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of OSBPL1A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of OSBPL1A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of OSBPL1A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of OSBPL1A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of OSBPL1A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of OSBPL1A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of OSBPL1A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with OSBPL1A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with OSBPL1A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of OSBPL1A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of OSBPL1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of OSBPL1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of OSBPL1A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of OSBPL1A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing OSBPL1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing OSBPL1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing OSBPL1A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with OSBPL1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with OSBPL1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of OSBPL1A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with OSBPL1A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with OSBPL1A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with OSBPL1A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with OSBPL1A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of OSBPL1A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by OSBPL1A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with OSBPL1A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with OSBPL1A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with OSBPL1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with OSBPL1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with OSBPL1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with OSBPL1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at OSBPL1A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of OSBPL1A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of OSBPL1A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.