OSBPL5 Gene

HGNC Family	Pleckstrin homology domain containing (PLEKH), Oxysterol binding proteins (OSBP)
Name	oxysterol binding protein-like 5
Description	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nOSBPL5, an endoplasmic reticulum–anchored oxysterol‐binding protein–related protein, plays a central role in non‐vesicular lipid transport at membrane contact sites. It mediates the counterexchange of key lipids—exchanging phosphatidylinositol 4‐phosphate (PI4P) for phosphatidylserine (PS) between the ER and the plasma membrane, while also contributing to cholesterol trafficking (through cooperation with NPC1 in endosomes/lysosomes) and ensuring proper mitochondrial function at ER–mitochondria contacts. These lipid exchange activities underpin the maintenance of membrane lipid composition and homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its lipid transfer functions, OSBPL5 engages in key cell signaling pathways that influence cellular growth and motility. By modulating mTOR complex 1 activity and locally regulated calcium signals, its dysregulation is linked to enhanced cell proliferation, migration, and invasion. Indeed, elevated OSBPL5 expression has been associated with the metastatic propensity and poor prognosis of cancers such as pancreatic, lung, and cervical, where it appears to promote malignancy partly through the suppression of endoplasmic reticulum stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ximing Du, Jaspal Kumar, Charles Ferguson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201004142"}], "href": "https://doi.org/10.1083/jcb.201004142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21220512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21220512"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jeeyun Chung, Federico Torta, Kaori Masai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aab1370"}], "href": "https://doi.org/10.1126/science.aab1370"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26206935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26206935"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Romain Galmes, Audrey Houcine, Alexander R van Vliet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORP5/ORP8 localize to endoplasmic reticulum-mitochondria contacts and are involved in mitochondrial function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201541108"}], "href": "https://doi.org/10.15252/embr.201541108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27113756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27113756"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rajesh Ghai, Ximing Du, Huan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORP5 and ORP8 bind phosphatidylinositol-4, 5-biphosphate (PtdIns(4,5)P "}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": ") and regulate its level at the plasma membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-00861-5"}], "href": "https://doi.org/10.1038/s41467-017-00861-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28970484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28970484"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mira Sohn, Marek Korzeniowski, James P Zewe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PI(4,5)P"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201710095"}], "href": "https://doi.org/10.1083/jcb.201710095"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29472386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29472386"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nina Criado Santos, Vladimir Girik, Paula Nunes-Hasler "}, {"type": "b", "children": [{"type": "t", "text": "ORP5 and ORP8: Sterol Sensors and Phospholipid Transfer Proteins at Membrane Contact Sites?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomolecules (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/biom10060928"}], "href": "https://doi.org/10.3390/biom10060928"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32570981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32570981"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yoshikatsu Koga, Shinji Ishikawa, Tadahiko Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxysterol binding protein-related protein-5 is related to invasion and poor prognosis in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2008.00987.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2008.00987.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19032366"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19032366"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kazuya Nagano, Sunao Imai, Xiluli Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2015.3000"}], "href": "https://doi.org/10.3892/ijo.2015.3000"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25963840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25963840"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ximing Du, Armella Zadoorian, Ivan E Lukmantara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxysterol-binding protein-related protein 5 (ORP5) promotes cell proliferation by activation of mTORC1 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA117.001558"}], "href": "https://doi.org/10.1074/jbc.RA117.001558"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29358326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29358326"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ilari Pulli, Taru Lassila, Guoping Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxysterol-binding protein related-proteins (ORPs) 5 and 8 regulate calcium signaling at specific cell compartments."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Calcium (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ceca.2018.03.001"}], "href": "https://doi.org/10.1016/j.ceca.2018.03.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29748134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29748134"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yi Wu, Luyao Min, Peng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ORP5 promotes migration and invasion of cervical cancer cells by inhibiting endoplasmic reticulum stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stress Chaperones (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12192-023-01357-6"}], "href": "https://doi.org/10.1007/s12192-023-01357-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37314629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37314629"}]}]}]}
Synonyms	OBPH1, ORP5
Proteins	OSBL5_HUMAN
NCBI Gene ID	114879
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

OSBPL5 has 4,891 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 108 datasets.

Click the + buttons to view associations for OSBPL5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

OSBPL5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of OSBPL5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of OSBPL5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of OSBPL5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of OSBPL5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of OSBPL5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of OSBPL5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of OSBPL5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of OSBPL5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of OSBPL5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of OSBPL5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with OSBPL5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with OSBPL5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of OSBPL5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of OSBPL5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of OSBPL5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing OSBPL5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing OSBPL5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with OSBPL5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with OSBPL5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with OSBPL5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with OSBPL5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with OSBPL5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with OSBPL5 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of OSBPL5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by OSBPL5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with OSBPL5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with OSBPL5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with OSBPL5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with OSBPL5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with OSBPL5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at OSBPL5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of OSBPL5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of OSBPL5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing OSBPL5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with OSBPL5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with OSBPL5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with OSBPL5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing OSBPL5 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of OSBPL5 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of OSBPL5 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.