{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nP2X3 receptors are ATP‐gated, trimeric cation channels whose unique structural features underlie their rapid activation and fast desensitization. High‐resolution structural studies have revealed distinct receptor conformations—including resting, open, desensitized, and antagonist‐bound states—and identified a “cytoplasmic cap” that stabilizes the open channel and provides lateral, lipid‐lined egress pathways for water and ions. Complementary mutagenesis and biophysical modeling have pinpointed key amino acids within the nucleotide binding sites and at the subunit interfaces that govern agonist binding, channel gating, and the kinetics of desensitization. In addition, divalent cations (e.g. Ca2+ and Mg2+) modulate receptor activation and prolong recovery from desensitization, while environmental factors such as the lipid microenvironment and even hypoxic conditions underscore the distinct regulatory properties of P2X3 compared with other P2X receptor subtypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nExpressed predominantly on primary sensory afferents and discrete neuronal populations, P2X3 receptors play a critical role in nociceptive signaling. Upon activation by extracellular ATP released during tissue injury or inflammation, these receptors mediate rapid depolarization and Ca2+ influx that contribute to both acute and chronic pain states—including neuropathic pain, burning mouth syndrome, and esophageal hypersensitivity. Furthermore, alterations in receptor expression and subunit composition (including heteromeric assembly with P2X2) modulate the intensity and duration of pain signals, as confirmed by gene‐targeting and antibody‐blockade studies that significantly attenuate hyperalgesia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its central role in pain signaling, the P2X3 receptor contributes to a spectrum of physiological and pathophysiological processes in non‐neuronal tissues. For example, in human pancreatic islets, channel activation by ATP—often co‐released with insulin—augments the beta cell’s responsiveness to glucose, providing a positive autocrine feedback that boosts insulin secretion. Altered P2X3 expression has also been associated with endometriosis pain, hepatocellular carcinoma proliferation, synovial inflammation in joint disease, and hyperthyroidism—all conditions in which dysregulated purinergic signaling appears to modulate inflammatory responses, cell cycle progression, or neuroendocrine communication. Collectively, these multifaceted roles underscore the promise of targeting P2X3 channels for therapeutic intervention across diverse clinical indications."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "30", "end_ref": "38"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Steven E Mansoor, Wei Lü, Wout Oosterheert, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Role of sodium ferulate in the nociceptive sensory facilitation of neuropathic pain injury mediated by P2X(3) receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurochem Int (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuint.2008.08.008"}], "href": "https://doi.org/10.1016/j.neuint.2008.08.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18805451"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18805451"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Anatoly Shcherbatko, Davide Foletti, Kris Poulsen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.722330"}], "href": "https://doi.org/10.1074/jbc.M116.722330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27129281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27129281"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Elsa Fabbretti, Andrea Nistri "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of P2X3 receptor structure and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "CNS Neurol Disord Drug Targets (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/187152712803581029"}], "href": "https://doi.org/10.2174/187152712803581029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22963434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22963434"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Daisuke Sato, Tadasu Sato, Yusuke Urata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distribution of TRPVs, P2X3, and parvalbumin in the human nodose ganglion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Neurobiol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10571-014-0062-9"}], "href": "https://doi.org/10.1007/s10571-014-0062-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24764033"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24764033"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xin Zhou, Li-Min Ma, Yan Xiong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulated P2X3 Receptor Expression in Patients with Intractable Temporal Lobe Epilepsy and in a Rat Model of Epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurochem Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11064-015-1820-x"}], "href": "https://doi.org/10.1007/s11064-015-1820-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26738991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26738991"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "K-R Shieh, S-C Yang, H-L Tseng, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Prenatal expression of purinergic receptor P2X3 in human dorsal root ganglion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Purinergic Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11302-011-9277-0"}], "href": "https://doi.org/10.1007/s11302-011-9277-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22052556"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22052556"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Ralf Hausmann, Mandy Bodnar, Ronja Woltersdorf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATP binding site mutagenesis reveals different subunit stoichiometry of functional P2X2/3 and P2X2/6 receptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.345207"}], "href": "https://doi.org/10.1074/jbc.M112.345207"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22378790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22378790"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "M Caroline Jacques-Silva, Mayrin Correa-Medina, Over Cabrera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0908935107"}], "href": "https://doi.org/10.1073/pnas.0908935107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20308565"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20308565"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Shaojie Ding, Libo Zhu, Yonghong Tian, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.6240"}], "href": "https://doi.org/10.18632/oncotarget.6240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26517690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26517690"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Andrómeda Liñán-Rico, Jacqueline E Wunderlich, Iveta S Grants, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Conformational flexibility of the agonist binding jaw of the human P2X3 receptor is a prerequisite for channel opening."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Pharmacol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bph.12830"}], "href": "https://doi.org/10.1111/bph.12830"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24989924"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24989924"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Hsin-Tzu Liu, Sung-Ho Chen, Michael B Chancellor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Presence of Cleaved Synaptosomal-Associated Protein-25 and Decrease of Purinergic Receptors P2X3 in the Bladder Urothelium Influence Efficacy of Botulinum Toxin Treatment for Overactive Bladder Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0134803"}], "href": "https://doi.org/10.1371/journal.pone.0134803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26241848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26241848"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Katia Varani, Monica De Mattei, Fabrizio Vincenzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P2X(1) and P2X(3) purinergic receptors differentially modulate the inflammatory response in human osteoarthritic synovial fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000276565"}], "href": "https://doi.org/10.1159/000276565"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20110693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20110693"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Wu Hong, Guodong Li, Yijun Nie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential Involvement of P2 Receptors in the Pathological Processes of Hyperthyroidism: A Pilot Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Clin Lab Sci (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27312548"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27312548"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Lucio Apicella, Elsa Fabbretti "}, {"type": "b", "children": [{"type": "t", "text": "P2X3 receptor expression by HEK cells conditions their survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Purinergic Signal (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11302-011-9285-0"}], "href": "https://doi.org/10.1007/s11302-011-9285-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22160848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22160848"}]}]}]}