P3H1 Gene

Name	prolyl 3-hydroxylase 1
Description	This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nProlyl 3‐hydroxylase 1 (P3H1), encoded by the LEPRE1 gene, is a key endoplasmic reticulum (ER) enzyme that catalyzes the 3‐hydroxylation of specific proline residues—most notably Pro986—in the α‐chains of fibrillar collagens. In this capacity, P3H1 assembles with cartilage‐associated protein (CRTAP) and cyclophilin B to form a collagen prolyl 3‐hydroxylation complex. This complex not only carries out a critical posttranslational modification required for proper collagen triple‐helix folding but also appears to contribute chaperone functions during collagen biosynthesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nLoss‐of‐function mutations in LEPRE1 disrupt P3H1 expression or impair its enzymatic activity, leading to deficient 3‐hydroxylation. This in turn delays collagen polypeptide folding and causes excessive overmodification by other hydroxylases. Such molecular defects are central to the pathogenesis of recessive osteogenesis imperfecta—often manifesting as severe skeletal fragility and, in many cases, a lethal phenotype. Restoration experiments indicate that P3H1 and CRTAP are mutually stabilizing components of the complex, emphasizing that their coordinated function is essential for normal collagen maturation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "17"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in collagen posttranslational modification, P3H1 contains distinct domains—including a 2‐oxoglutarate–dependent dioxygenase region and a conserved carboxyl‐terminal KDEL sequence crucial for ER retention—that are vital for its enzymatic function. Moreover, the presence of CXXXC motifs in its amino‐terminal region has raised the possibility that it may exert oxidoreductase activity akin to protein disulfide isomerase, assisting in disulfide bond formation. Recent studies also implicate LEPRE1/P3H1 in non‐collagenous contexts such as modulation of tumor cell signaling and the regulation of odontoblastic differentiation, suggesting that its functional repertoire may extend to influencing cell differentiation and tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "20"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Dustin Baldridge, Ulrike Schwarze, Roy Morello, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRTAP and LEPRE1 mutations in recessive osteogenesis imperfecta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.20799"}], "href": "https://doi.org/10.1002/humu.20799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18566967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18566967"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Dale L Bodian, Ting-Fung Chan, Annie Poon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation and polymorphism spectrum in osteogenesis imperfecta type II: implications for genotype-phenotype relationships."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddn374"}], "href": "https://doi.org/10.1093/hmg/ddn374"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18996919"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18996919"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "A Willaert, F Malfait, S Symoens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recessive osteogenesis imperfecta caused by LEPRE1 mutations: clinical documentation and identification of the splice form responsible for prolyl 3-hydroxylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2008.062729"}], "href": "https://doi.org/10.1136/jmg.2008.062729"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19088120"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19088120"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Joan C Marini, Wayne A Cabral, Aileen M Barnes "}, {"type": "b", "children": [{"type": "t", "text": "Null mutations in LEPRE1 and CRTAP cause severe recessive osteogenesis imperfecta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Tissue Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00441-009-0872-0"}], "href": "https://doi.org/10.1007/s00441-009-0872-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19862557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19862557"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Masaki Takagi, Tomohiro Ishii, Aileen M Barnes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel mutation in LEPRE1 that eliminates only the KDEL ER- retrieval sequence causes non-lethal osteogenesis imperfecta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0036809"}], "href": "https://doi.org/10.1371/journal.pone.0036809"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22615817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22615817"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Weizhong Chang, Aileen M Barnes, Wayne A Cabral, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prolyl 3-hydroxylase 1 and CRTAP are mutually stabilizing in the endoplasmic reticulum collagen prolyl 3-hydroxylation complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddp481"}], "href": "https://doi.org/10.1093/hmg/ddp481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19846465"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19846465"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fleur S van Dijk, Peter G J Nikkels, Nicolette S den Hollander, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lethal/severe osteogenesis imperfecta in a large family: a novel homozygous LEPRE1 mutation and bone histological findings."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Dev Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2350/10-03-0806-CR.1"}], "href": "https://doi.org/10.2350/10-03-0806-CR.1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20946018"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20946018"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zhen-Lin Zhang, Hao Zhang, Yao-hua Ke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The identification of novel mutations in COL1A1, COL1A2, and LEPRE1 genes in Chinese patients with osteogenesis imperfecta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00774-011-0284-6"}], "href": "https://doi.org/10.1007/s00774-011-0284-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21667357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21667357"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Wayne A Cabral, Aileen M Barnes, Adebowale Adeyemo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A founder mutation in LEPRE1 carried by 1.5% of West Africans and 0.4% of African Americans causes lethal recessive osteogenesis imperfecta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Med (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/gim.2011.44"}], "href": "https://doi.org/10.1038/gim.2011.44"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22281939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22281939"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yoshihiro Ishikawa, Hans Peter Bächinger "}, {"type": "b", "children": [{"type": "t", "text": "An additional function of the rough endoplasmic reticulum protein complex prolyl 3-hydroxylase 1·cartilage-associated protein·cyclophilin B: the CXXXC motif reveals disulfide isomerase activity in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.498063"}], "href": "https://doi.org/10.1074/jbc.M113.498063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24043621"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24043621"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "C Barbirato, M Trancozo, M G Almeida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutational characterization of the P3H1/CRTAP/CypB complex in recessive osteogenesis imperfecta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/2015.December.1.36"}], "href": "https://doi.org/10.4238/2015.December.1.36"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26634552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26634552"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nadja Fratzl-Zelman, Aileen M Barnes, MaryAnn Weis, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A new case of osteogenesis imperfecta type VIII and retinal detachment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.61934"}], "href": "https://doi.org/10.1002/ajmg.a.61934"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33098264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33098264"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Piranit Nik Kantaputra, Prapai Dejkhamron, Worrachet Intachai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel P3H1 mutation is associated with osteogenesis imperfecta type VIII and dental anomalies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Surg Oral Med Oral Pathol Oral Radiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.oooo.2021.01.023"}], "href": "https://doi.org/10.1016/j.oooo.2021.01.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33737016"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33737016"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Dina Nadyrshina, Aliya Zaripova, Anton Tyurin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteogenesis Imperfecta: Search for Mutations in Patients from the Republic of Bashkortostan (Russia)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes (Basel) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/genes13010124"}], "href": "https://doi.org/10.3390/genes13010124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35052464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35052464"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Lidiia Zhytnik, Binh Ho Duy, Marelise Eekhoff, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Upregulated LEPRE1 correlates with poor outcome and its knockdown attenuates cells proliferation, migration and invasion in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Drugs (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/CAD.0000000000000851"}], "href": "https://doi.org/10.1097/CAD.0000000000000851"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32197005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32197005"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "A-Ram Lee, Sunho Lee, Jee Yoon Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biomarker LEPRE1 induces pelitinib-specific drug responsiveness by regulating ABCG2 expression and tumor transition states in human leukemia and lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-022-06621-w"}], "href": "https://doi.org/10.1038/s41598-022-06621-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35190588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35190588"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kyung-Jung Kang, Min-Jeong Choi, Tae-Jun Min, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cell Surface Accumulation of Intracellular Leucine Proline-Enriched Proteoglycan 1 Enhances Odontogenic Potential of Human Dental Pulp Stem Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells Dev (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/scd.2022.0174"}], "href": "https://doi.org/10.1089/scd.2022.0174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35859453"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35859453"}]}]}]}
Synonyms	GROS1, OI8, LEPRE1
Proteins	P3H1_HUMAN
NCBI Gene ID	64175
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

P3H1 has 6,707 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 118 datasets.

Click the + buttons to view associations for P3H1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

P3H1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by P3H1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of P3H1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of P3H1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of P3H1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of P3H1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of P3H1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of P3H1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of P3H1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of P3H1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of P3H1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of P3H1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with P3H1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with P3H1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of P3H1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of P3H1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of P3H1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with P3H1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of P3H1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing P3H1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing P3H1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing P3H1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing P3H1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with P3H1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with P3H1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of P3H1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with P3H1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with P3H1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by P3H1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving P3H1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving P3H1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with P3H1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with P3H1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with P3H1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with P3H1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for P3H1 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at P3H1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of P3H1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of P3H1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing P3H1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of P3H1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.