P4HA2 Gene

Name	prolyl 4-hydroxylase, alpha polypeptide II
Description	This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nCollagen prolyl‐4‐hydroxylase subunit alpha‐2 (P4HA2) is a critical enzyme that catalyzes the hydroxylation of proline residues within -X–Pro–Gly– motifs, a necessary post‐translational modification for proper collagen triple helix formation and extracellular matrix assembly. Structural and biochemical analyses have delineated distinct substrate‐binding regions that govern its enzymatic specificity and efficiency, while transcriptional regulation by factors such as p53 links its expression to pathways involved in antiangiogenesis. Furthermore, mutations or altered expression in P4HA2 can disrupt collagen maturation, contributing not only to pathologic fibrotic states but also to ocular conditions like high myopia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "Disordered or elevated expression of P4HA2 is increasingly recognized as a driving force in tumor progression through its modulation of the extracellular matrix. Overexpression of P4HA2 enhances collagen deposition and remodeling, thereby facilitating tumor cell invasion, migration, and metastasis in malignancies such as breast cancer, oral squamous cell carcinoma, and hepatocellular carcinoma. In some soft tissue tumors, chromosomal rearrangements may fuse P4HA2 with other genes, while its upregulation correlates with aggressive disease features and poor outcomes. In addition, studies have shown that P4HA2 levels are altered in lymph node metastases and implicated in vascular remodeling processes, supporting its role as a biomarker and potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "13"}]}, {"type": "t", "text": "Beyond its central role in collagen maturation, P4HA2 has emerged as a key mediator of oncogenic signaling. Its aberrant expression is linked to the activation of pathways such as PI3K/AKT and the induction of epithelial–mesenchymal transition, thereby promoting tumor growth, metastasis, and resistance to therapies across a spectrum of cancers including uveal melanoma, prostate cancer, lung adenocarcinoma, glioma, colorectal cancer, and head and neck squamous cell carcinoma. Intriguingly, P4HA2 also participates in feedback loops with transcription factors and modulates drug responsiveness, underscoring its potential utility as a prognostic marker and a promising target for therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "24"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Reija Hieta, Liisa Kukkola, Perttu Permi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The peptide-substrate-binding domain of human collagen prolyl 4-hydroxylases. Backbone assignments, secondary structure, and binding of proline-rich peptides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M303624200"}], "href": "https://doi.org/10.1074/jbc.M303624200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12824157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12824157"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Claudia Grimmer, Nadine Balbus, Ute Lang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2006.050738"}], "href": "https://doi.org/10.2353/ajpath.2006.050738"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16877351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16877351"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jose G Teodoro, Albert E Parker, Xiaochun Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1126391"}], "href": "https://doi.org/10.1126/science.1126391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16917063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16917063"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mark S Silverberg, Richard H Duerr, Steven R Brant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.ejhg.5201756"}], "href": "https://doi.org/10.1038/sj.ejhg.5201756"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17213842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17213842"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gaofeng Xiong, Lei Deng, Jieqing Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-14-1"}], "href": "https://doi.org/10.1186/1471-2407-14-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24383403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24383403"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kai-Ping Chang, Jau-Song Yu, Kun-Yi Chien, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of PRDX4 and P4HA2 as metastasis-associated proteins in oral cavity squamous cell carcinoma by comparative tissue proteomics of microdissected specimens using iTRAQ technology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/pr200311p"}], "href": "https://doi.org/10.1021/pr200311p"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21859152"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21859152"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ioannis Panagopoulos, Ludmila Gorunova, Trond Viset, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene fusions AHRR-NCOA2, NCOA2-ETV4, ETV4-AHRR, P4HA2-TBCK, and TBCK-P4HA2 resulting from the translocations t(5;8;17)(p15;q13;q21) and t(4;5)(q24;q31) in a soft tissue angiofibroma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5096"}], "href": "https://doi.org/10.3892/or.2016.5096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27633981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27633981"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "F David Carmona, Augusto Vaglio, Sarah L Mackie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2016.11.013"}], "href": "https://doi.org/10.1016/j.ajhg.2016.11.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28041642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28041642"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "M Kristian Koski, Jothi Anantharajan, Petri Kursula, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Assembly of the elongated collagen prolyl 4-hydroxylase α"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": "β"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " heterotetramer around a central α"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " dimer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20161000"}], "href": "https://doi.org/10.1042/BCJ20161000"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28093469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28093469"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "F Napolitano, V Di Iorio, F Testa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autosomal-dominant myopia associated to a novel P4HA2 missense variant and defective collagen hydroxylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.13217"}], "href": "https://doi.org/10.1111/cge.13217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29364500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29364500"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Wei Jiang, Xiaoyan Zhou, Zengxia Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of Carabin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2017-07-794875"}], "href": "https://doi.org/10.1182/blood-2017-07-794875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29437589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29437589"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Michael S Toss, Islam M Miligy, Kylie L Gorringe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prolyl-4-hydroxylase Α subunit 2 (P4HA2) expression is a predictor of poor outcome in breast ductal carcinoma in situ (DCIS)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41416-018-0337-x"}], "href": "https://doi.org/10.1038/s41416-018-0337-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30410060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30410060"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Dingyuan Hu, Daniel Ansari, Qimin Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low P4HA2 and high PRTN3 expression predicts poor survival in patients with pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Scand J Gastroenterol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/00365521.2019.1574360"}], "href": "https://doi.org/10.1080/00365521.2019.1574360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30880498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30880498"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Stefan Kaluz, Qing Zhang, Yuki Kuranaga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-01919-x"}], "href": "https://doi.org/10.1038/s41388-021-01919-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34218269"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34218269"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mingjie Li, Qianyun Wang, Qinqin Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomark Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/bmm-2020-0323"}], "href": "https://doi.org/10.2217/bmm-2020-0323"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34387118"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34387118"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ming Zhu, Ruiqing Peng, Xin Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-02000-3"}], "href": "https://doi.org/10.1038/s41388-021-02000-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34471235"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34471235"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "L Shang, W Jiang, J Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[P4HA2 promotes occurrence and progression of liver cancer by regulating the PI3K/Akt/mTOR signaling pathway]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2022.05.06"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2022.05.06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35673909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35673909"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiao-Hong Lu, Die Sang, Yu-Rong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of prolyl 4-hydroxylase subunit alpha-2 in lung adenocarcinoma indicates poor prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clinics (Sao Paulo) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clinsp.2022.100123"}], "href": "https://doi.org/10.1016/j.clinsp.2022.100123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36403427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36403427"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Shuai Wang, Jingheng Wu, Wujun Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CEBPB upregulates P4HA2 to promote the malignant biological behavior in IDH1 wildtype glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202201244RRRR"}], "href": "https://doi.org/10.1096/fj.202201244RRRR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36906285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36906285"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Xuexiang Li, Yunxue Li, Bing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P4HA2-mediated HIF-1α stabilization promotes erdafitinib-resistance in FGFR3-alteration bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202201247R"}], "href": "https://doi.org/10.1096/fj.202201247R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36943397"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36943397"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Heba El-Deek Mohammed El-Deek, Maha Salah El-Naggar, Aiat Morsy Mohamed Morsy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P4HA2 involved in SLUG-associated EMT predicts poor prognosis of patients with KRAS-positive colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Mol Morphol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00795-024-00385-0"}], "href": "https://doi.org/10.1007/s00795-024-00385-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38522060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38522060"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yan-Ling Wu, Wan Liu, Tingting Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P4HA2 contributes to head and neck squamous cell carcinoma progression and EMT through PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-024-02358-w"}], "href": "https://doi.org/10.1007/s12032-024-02358-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38777998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38777998"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Xuening Dang, Xiaojian Chen, Zhonglin Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P4HA2 promotes tumor progression and is transcriptionally regulated by SP1 in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2024.2361594"}], "href": "https://doi.org/10.1080/15384047.2024.2361594"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38857058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38857058"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Zengpeng Chi, Qimin Wang, Xin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "P4HA2 promotes proliferation, invasion, and metastasis through regulation of the PI3K/AKT signaling pathway in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-64264-5"}], "href": "https://doi.org/10.1038/s41598-024-64264-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38951593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38951593"}]}]}]}
Synonyms	MYP25
Proteins	P4HA2_HUMAN
NCBI Gene ID	8974
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

P4HA2 has 11,682 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 131 datasets.

Click the + buttons to view associations for P4HA2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

P4HA2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of P4HA2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of P4HA2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of P4HA2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of P4HA2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of P4HA2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of P4HA2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of P4HA2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of P4HA2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of P4HA2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of P4HA2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of P4HA2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of P4HA2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with P4HA2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with P4HA2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of P4HA2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of P4HA2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of P4HA2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with P4HA2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of P4HA2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing P4HA2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of P4HA2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing P4HA2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing P4HA2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing P4HA2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing P4HA2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with P4HA2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with P4HA2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with P4HA2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with P4HA2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with P4HA2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with P4HA2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of P4HA2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by P4HA2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving P4HA2 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with P4HA2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with P4HA2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with P4HA2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with P4HA2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with P4HA2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with P4HA2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.