{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPABPC1 is a pivotal regulator of mRNA translation and stability. By binding to the 3′ poly(A) tail, it promotes mRNA circularization through an interaction with eIF4G, thereby stimulating cap‐dependent translation initiation. Structural studies have further revealed how PABPC1 facilitates recruitment of ribosome release factors to ensure efficient translation termination, while its various RNA recognition motifs enable autoregulatory interactions that integrate initiation and termination with broader mRNA metabolism."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in promoting translation, PABPC1 is intimately involved in mRNA surveillance and turnover. It can antagonize nonsense‐mediated mRNA decay when positioned near premature termination codons, and its C‐terminal MLLE domain serves as a docking site for factors such as GW182 that mediate microRNA‐dependent silencing. PABPC1 also helps recruit deadenylase complexes through interactions with proteins like TOB and PAN3, thereby linking poly(A) tail dynamics to mRNA decay and gene silencing processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPABPC1 also functions as a molecular nexus in cellular stress responses, viral infections, and cancer. Under stress conditions such as those observed in amyotrophic lateral sclerosis, PABPC1 frequently redistributes to stress granules and becomes abnormally accumulated alongside proteins like TDP‑43. 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"}, {"type": "b", "children": [{"type": "t", "text": "Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2853"}], "href": "https://doi.org/10.1038/ng.2853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24336168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24336168"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jing-Wen Shih, Wei-Ting Wang, Tsung-Yuan Tsai, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00872-08"}], "href": "https://doi.org/10.1128/JVI.00872-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18799579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18799579"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Jennifer M Bonderoff, Jennifer L Larey, Richard E Lloyd "}, {"type": "b", "children": [{"type": "t", "text": "Cleavage of poly(A)-binding protein by poliovirus 3C proteinase inhibits viral internal ribosome entry site-mediated translation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00006-08"}], "href": "https://doi.org/10.1128/JVI.00006-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18632855"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18632855"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Gjon Blakqori, Ingeborg van Knippenberg, Richard M Elliott "}, {"type": "b", "children": [{"type": "t", "text": "Bunyamwera orthobunyavirus S-segment untranslated regions mediate poly(A) tail-independent translation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.02201-08"}], "href": "https://doi.org/10.1128/JVI.02201-08"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19193790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19193790"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kengo Fujita, Hidefumi Ito, Satoshi Nakano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Immunohistochemical identification of messenger RNA-related proteins in basophilic inclusions of adult-onset atypical motor neuron disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00401-008-0415-x"}], "href": "https://doi.org/10.1007/s00401-008-0415-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18642007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18642007"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Lixin Dai, Martin S Taylor, Kathryn A O'Donnell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Poly(A) binding protein C1 is essential for efficient L1 retrotransposition and affects L1 RNP formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.06785-11"}], "href": "https://doi.org/10.1128/MCB.06785-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22907758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22907758"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "C Salaun, A I MacDonald, O Larralde, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Poly(A)-binding protein 1 partially relocalizes to the nucleus during herpes simplex virus type 1 infection in an ICP27-independent manner and does not inhibit virus replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00668-10"}], "href": "https://doi.org/10.1128/JVI.00668-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20573819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20573819"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Huaying Dong, Wei Wang, Shaowei Mo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA SNHG14 induces trastuzumab resistance of breast cancer via regulating PABPC1 expression through H3K27 acetylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13758"}], "href": "https://doi.org/10.1111/jcmm.13758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30063126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30063126"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Hui Zhang, Cheng Sheng, Yongjia Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PABPC1 interacts with AGO2 and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2015.07.010"}], "href": "https://doi.org/10.1016/j.canlet.2015.07.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26188282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26188282"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Rui Su, Jun Ma, Jian Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PABPC1-induced stabilization of BDNF-AS inhibits malignant progression of glioblastoma cells through STAU1-mediated decay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2267-9"}], "href": "https://doi.org/10.1038/s41419-020-2267-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32015336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32015336"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Ying Zhang, Chuangzhen Chen, Zhaoyong Liu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LncRNA SNHG14 promotes hepatocellular carcinoma progression via H3K27 acetylation activated PABPC1 by PTEN signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-02808-z"}], "href": "https://doi.org/10.1038/s41419-020-02808-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32811821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32811821"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Nobuhiro Takashima, Hideyuki Ishiguro, Yoshiyuki Kuwabara, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "PABPC1 exerts carcinogenesis in gastric carcinoma by targeting miR-34c."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26097561"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26097561"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Keiichi Ohshima, Kaori Kanto, Keiichi Hatakeyama, et al. 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