{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have highlighted the importance of non‐genomic steroid signaling in the regulation of vascular function and blood pressure. In particular, membrane‐associated scaffold proteins have been shown to interact with steroid receptors—such as the mineralocorticoid receptor—to modulate both rapid signaling pathways and downstream genomic targets. For example, work in rodent models demonstrates that alterations in striatin, a protein that interfaces with steroid receptors, result in salt‐sensitive blood pressure changes and modifications in renal receptor expression and vascular reactivity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast to these studies on vascular steroid signaling, investigations into cancer–testis (CT) gene expression uncovered the dynamic regulation of PAGE2 in cancer cells. In colorectal cancer cell models, PAGE2—as well as related CT genes—was found to be up‐regulated during a mesenchymal‐to‐epithelial transition (MET) associated with spontaneous cellular differentiation. This up‐regulation was accompanied by increased expression of Ten‐eleven translocation-2 (TET2), enhanced cytosine 5-hydroxymethylation, and a reduction in repressive chromatin markers (HP1 and EZH2) at promoter regions. Collectively, these findings indicate that PAGE2 may serve as an epigenetically regulated marker of differentiation, suggesting a potential role in modulating tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Luminita H Pojoga, Patricia Coutinho, Alicia Rivera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of the mineralocorticoid receptor increases striatin levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hypertens (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ajh.2011.197"}], "href": "https://doi.org/10.1038/ajh.2011.197"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22089104"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22089104"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Amanda E Garza, Chevon M Rariy, Bei Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variants in striatin gene are associated with salt-sensitive blood pressure in mice and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.114.04233"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.114.04233"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25368024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25368024"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Amanda E Garza, Luminita H Pojoga, Burhanuddin Moize, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hypertension (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/HYPERTENSIONAHA.115.05600"}], "href": "https://doi.org/10.1161/HYPERTENSIONAHA.115.05600"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26169051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26169051"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sinem Yilmaz-Ozcan, Asli Sade, Baris Kucukkaraduman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0107905"}], "href": "https://doi.org/10.1371/journal.pone.0107905"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25229454"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25229454"}]}]}]}