PAXIP1 Gene

HGNC Family	Trinucleotide repeat containing (TNRC)
Name	PAX interacting (with transcription-activation domain) protein 1
Description	This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPTIP (Pax transactivation domain‐interacting protein) plays a central role in the cellular DNA damage response. Acting through its multiple BRCT domains, PTIP is rapidly recruited to sites of DNA breakage by recognizing phosphorylated epitopes on key repair proteins such as 53BP1 and γH2AX. In doing so, it facilitates ATM‐dependent signaling events, promotes homologous recombination as well as nonhomologous end-joining repair (including cooperating with Artemis), and helps to recruit factors such as PCNA and specialized DNA polymerases during replicative stress. Loss or mutation of PTIP compromises p53 and SMC1 phosphorylation, disrupts sustained 53BP1 localization, and thereby increases sensitivity to ionizing radiation and other genotoxic insults."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its direct role in repair, PTIP is a key epigenetic regulator that functions as a component of Set1-like histone methyltransferase complexes. Through its association with core complex members (including ASH2L, RBBP5, WDR5, and others), PTIP mediates histone H3 lysine 4 methylation, a mark of active chromatin, thereby influencing transcriptional activation. Moreover, PTIP interacts with transcription factors such as Pax2, where its binding can attenuate or modulate Pax2-driven gene expression—a process that is dynamically regulated by co-factors (for example, by displacement through PPM1B-mediated dephosphorylation). This interplay helps switch Pax2 from an activator to a repressor, underscoring the complexity of transcriptional control."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond DNA repair and transcription, PTIP is implicated in diverse biological processes. For instance, PTIP is critical for adipogenesis by regulating the expression of key adipogenic transcription factors (PPARγ and C/EBPα), and its deficiency leads to profound defects in fat cell differentiation. In cancer contexts, PTIP levels have been correlated with tumor grade and therapeutic response—its interaction with cell cycle kinases such as WEE1 has been exploited to enhance the efficacy of DNA-damaging chemotherapy, particularly in lung and breast tumors. Additionally, PTIP regulates metabolic pathways in macrophages by controlling CD38 expression, thereby influencing NAD⁺ metabolism and the inflammatory response. Finally, genetic polymorphisms within the PTIP gene are associated with altered sperm motility, pointing to a broader role in reproductive health."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Isaac A Manke, Drew M Lowery, Anhco Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BRCT repeats as phosphopeptide-binding modules involved in protein targeting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1088877"}], "href": "https://doi.org/10.1126/science.1088877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14576432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14576432"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Paul A Jowsey, Aidan J Doherty, John Rouse "}, {"type": "b", "children": [{"type": "t", "text": "Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M411021200"}], "href": "https://doi.org/10.1074/jbc.M411021200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15456759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15456759"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ivan M Munoz, Paul A Jowsey, Rachel Toth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkm493"}], "href": "https://doi.org/10.1093/nar/gkm493"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17690115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17690115"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Thomas Göhler, Ivan M Munoz, John Rouse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Repair (Amst) (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.dnarep.2008.02.001"}], "href": "https://doi.org/10.1016/j.dnarep.2008.02.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18353733"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18353733"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zihua Gong, Young-Wook Cho, Ja-Eun Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M809158200"}], "href": "https://doi.org/10.1074/jbc.M809158200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19124460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19124460"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jiaxue Wu, Marc J Prindle, Gregory R Dressler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTIP regulates 53BP1 and SMC1 at the DNA damage sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.002527"}], "href": "https://doi.org/10.1074/jbc.M109.002527"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19414588"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19414588"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xin Wang, Katsuya Takenaka, Shunichi Takeda "}, {"type": "b", "children": [{"type": "t", "text": "PTIP promotes DNA double-strand break repair through homologous recombination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2009.01379.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2009.01379.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20088963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20088963"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wei Yan, Zhenhua Shao, Fudong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of γH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2011.10.045"}], "href": "https://doi.org/10.1016/j.febslet.2011.10.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22064073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22064073"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hong Xiao, Zhigang Yu, Yipin Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/dds246"}], "href": "https://doi.org/10.1093/hmg/dds246"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22736030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22736030"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jiadong Wang, Asaithamby Aroumougame, Markus Lobrich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTIP associates with Artemis to dictate DNA repair pathway choice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.252478.114"}], "href": "https://doi.org/10.1101/gad.252478.114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25512557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25512557"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yuichiro Nakata, Shion Nagasawa, Yasuyuki Sera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTIP epigenetically regulates DNA damage-induced cell cycle arrest by upregulating PRDM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-68295-w"}], "href": "https://doi.org/10.1038/s41598-024-68295-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39097652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39097652"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Albrecht Hoffmeister, Alejandro Ropolo, Sophie Vasseur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The HMG-I/Y-related protein p8 binds to p300 and Pax2 trans-activation domain-interacting protein to regulate the trans-activation activity of the Pax2A and Pax2B transcription factors on the glucagon gene promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201657200"}], "href": "https://doi.org/10.1074/jbc.M201657200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11940591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11940591"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Young-Wook Cho, Teresa Hong, Sunhwa Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M701574200"}], "href": "https://doi.org/10.1074/jbc.M701574200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17500065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17500065"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yan Liu, Yue Huang, Jun Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PITX2 associates with PTIP-containing histone H3 lysine 4 methyltransferase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2014.01.143"}], "href": "https://doi.org/10.1016/j.bbrc.2014.01.143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24486544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24486544"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Saji Abraham, Raghavendra Paknikar, Samina Bhumbra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.607424"}], "href": "https://doi.org/10.1074/jbc.M114.607424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25631048"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25631048"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Young-Wook Cho, SunHwa Hong, Qihuang Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2009.05.010"}], "href": "https://doi.org/10.1016/j.cmet.2009.05.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19583951"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19583951"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ankita Jhuraney, Nicholas T Woods, Gabriela Wright, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PAXIP1 Potentiates the Combination of WEE1 Inhibitor AZD1775 and Platinum Agents in Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-15-0182"}], "href": "https://doi.org/10.1158/1535-7163.MCT-15-0182"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27196765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27196765"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Giuliana De Gregoriis, Juliene Antonio Ramos, Priscila Valverde Fernandes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNA repair genes PAXIP1 and TP53BP1 expression is associated with breast cancer prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15384047.2017.1323590"}], "href": "https://doi.org/10.1080/15384047.2017.1323590"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28475402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28475402"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Qifan Wang, Jin Hu, Guoqiang Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTIP governs NAD"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " metabolism by regulating CD38 expression to drive macrophage inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2022.110603"}], "href": "https://doi.org/10.1016/j.celrep.2022.110603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35354042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35354042"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Nishi Gupta, Saumya Sarkar, Poonam Mehta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Andrologia (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/and.14517"}], "href": "https://doi.org/10.1111/and.14517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35768906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35768906"}]}]}]}
Synonyms	TNRC2, PAXIP1L, CAGF28, PTIP, CAGF29, PACIP1
Proteins	PAXI1_HUMAN
NCBI Gene ID	22976
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PAXIP1 has 7,350 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 116 datasets.

Click the + buttons to view associations for PAXIP1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PAXIP1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PAXIP1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PAXIP1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PAXIP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PAXIP1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PAXIP1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PAXIP1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PAXIP1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PAXIP1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PAXIP1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PAXIP1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PAXIP1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with PAXIP1 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PAXIP1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PAXIP1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PAXIP1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PAXIP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PAXIP1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PAXIP1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PAXIP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PAXIP1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PAXIP1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PAXIP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PAXIP1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing PAXIP1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PAXIP1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PAXIP1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with PAXIP1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PAXIP1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PAXIP1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PAXIP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PAXIP1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PAXIP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PAXIP1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PAXIP1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PAXIP1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PAXIP1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PAXIP1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PAXIP1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PAXIP1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PAXIP1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.