{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPBX1 is a highly pleiotropic transcription factor that plays fundamental roles in normal development and tissue homeostasis. It has been shown to modulate immunoregulatory cytokine production—for example, IL‐10 transcription in phagocytes responding to apoptotic cells depends on PBX1 along with other cofactors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Structural and biochemical studies have revealed that PBX1 cooperates with HOX proteins to confer positional identity during embryogenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", while its essential functions extend to organogenesis. In the pancreas, PBX1 is indispensable for both endocrine and exocrine cell differentiation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and it participates in maintaining stem cell pluripotency through activation of NANOG transcription."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Genetic studies have further implicated PBX1 in kidney development, where loss‐of‐function mutations cause congenital anomalies of the kidney and urinary tract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and in the specification and survival of midbrain dopaminergic neurons."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In the developing eye, PBX1 complex formation with Pax6 and related factors contributes to fine‐tuning gene regulation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", and its activity is critical for proper cortical patterning."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " PBX1 also engages with cofactors such as MEIS1 to drive megakaryocytic differentiation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", regulates angiogenesis in endothelial cells"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and is involved in delaying mesenchymal stem cell senescence and promoting regenerative potential"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Moreover, intrinsic molecular dynamics—including a transient helix formation within its unbound conformation—prime PBX1 for binding its DNA targets."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Finally, rare missense variants in PBX1 have been linked to congenital malformations, including defects in Müllerian duct development"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pathological contexts, aberrant expression or genetic alterations of PBX1 underscore its oncogenic and dysregulatory potential. PBX1 functions as a pioneer factor that guides estrogen receptor–mediated transcription in aggressive breast cancers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ", and its deregulation is central to leukemogenesis via the recurrent E2A‐PBX1 fusion that suppresses tumor suppressor loci through cooperation with proteins such as BMI‐1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "and by direct interaction with coactivators like CBP."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Moreover, PBX1 is implicated in transcriptional reprogramming in myeloid progenitors, as loss of its repression by Gfi1 contributes to progenitor transformation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": ", while deregulated expression induced by oncogenic factors such as Evi-1 further reinforces its role in hematopoietic malignancies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": " Beyond hematologic cancers, PBX1 promotes the expression of genes like RNF6 in leukemia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "and modulates lipid metabolism gene networks that correlate with aggressive ER–negative breast tumors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": " Its oncogenic activities extend to solid tumors as well; for instance, PBX1 contributes to chemoresistance in prostate cancer by stabilizing proliferative and survival pathways"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": ", is transcriptionally upregulated downstream of Notch3 in ovarian cancers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": ", and interacts with RUNX1 to enforce a leukemic transcriptome in pre–B cell acute lymphoblastic leukemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": " Aberrant splice isoforms of PBX1 have been linked to autoimmune dysregulation in systemic lupus erythematosus"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": ", and additional studies in renal clear cell carcinoma have highlighted its role in activating JAK2/STAT3 signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "28"}]}, {"type": "t", "text": " Furthermore, experimental models underscore that E2A–PBX1 is critical for leukemic transformation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "29"}]}, {"type": "t", "text": ", a finding supported by epidemiological studies on its prevalence in childhood acute lymphoblastic leukemia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "30"}]}, {"type": "t", "text": "and by mechanistic insights into the importance of the conserved hexapeptide motif for its transforming activity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "31"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Elaine Y Chung, Jianguo Liu, Yoichiro Homma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2007.11.014"}], "href": "https://doi.org/10.1016/j.immuni.2007.11.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18093541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18093541"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Nicole A LaRonde-LeBlanc, Cynthia Wolberger "}, {"type": "b", "children": [{"type": "t", "text": "Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1103303"}], "href": "https://doi.org/10.1101/gad.1103303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12923056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12923056"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Seung K Kim, Licia Selleri, Joon S Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng860"}], "href": "https://doi.org/10.1038/ng860"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11912494"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11912494"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ken Kwok-Keung Chan, Jingyao Zhang, Na-Yu Chia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cells (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/stem.143"}], "href": "https://doi.org/10.1002/stem.143"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19522013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19522013"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Laurence Heidet, Vincent Morinière, Charline Henry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted Exome Sequencing Identifies "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PBX1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " as Involved in Monogenic Congenital Anomalies of the Kidney and Urinary Tract."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Soc Nephrol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1681/ASN.2017010043"}], "href": "https://doi.org/10.1681/ASN.2017010043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28566479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28566479"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Pauline Le Tanno, Julie Breton, Marie Bidart, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PBX1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " haploinsufficiency leads to syndromic congenital anomalies of the kidney and urinary tract (CAKUT) in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2016-104435"}], "href": "https://doi.org/10.1136/jmedgenet-2016-104435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28270404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28270404"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "J Carlos Villaescusa, Bingsi Li, Enrique M Toledo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201593725"}], "href": "https://doi.org/10.15252/embj.201593725"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27354364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27354364"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "I Mikkola, J A Bruun, T Holm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Superactivation of Pax6-mediated transactivation from paired domain-binding sites by dna-independent recruitment of different homeodomain proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M008882200"}], "href": "https://doi.org/10.1074/jbc.M008882200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11069920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11069920"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jin-Gyoung Jung, Ie-Ming Shih, Joon Tae Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-16-0980"}], "href": "https://doi.org/10.1158/0008-5472.CAN-16-0980"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27590741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27590741"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yoshiaki Okada, Ryohei Nagai, Takahiro Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-02-0380"}], "href": "https://doi.org/10.1182/blood-2002-02-0380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12609849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12609849"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "A Charboneau, L East, N Mulholland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pbx1 is required for Hox D3-mediated angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Angiogenesis (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10456-005-9016-7"}], "href": "https://doi.org/10.1007/s10456-005-9016-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16328158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16328158"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Feilin Liu, Jiahong Shi, Yingyao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oxid Med Cell Longev (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2019/4286213"}], "href": "https://doi.org/10.1155/2019/4286213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31885790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31885790"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yixu Jiang, Feilin Liu, Fei Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Stem Cell Res Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13287-019-1382-y"}], "href": "https://doi.org/10.1186/s13287-019-1382-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31443676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31443676"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Patrick J Farber, Anthony Mittermaier "}, {"type": "b", "children": [{"type": "t", "text": "Concerted dynamics link allosteric sites in the PBX homeodomain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2010.11.016"}], "href": "https://doi.org/10.1016/j.jmb.2010.11.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21087615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21087615"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Dimuthu Alankarage, Justin O Szot, Nick Pachter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional characterization of a novel PBX1 de novo missense variant identified in a patient with syndromic congenital heart disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddz231"}], "href": "https://doi.org/10.1093/hmg/ddz231"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31625560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31625560"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jinlong Ma, Yingying Qin, Wen Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of PBX1 mutations in 192 Chinese women with Müllerian duct abnormalities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fertil Steril (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.fertnstert.2011.04.074"}], "href": "https://doi.org/10.1016/j.fertnstert.2011.04.074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21575942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21575942"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Luca Magnani, Elizabeth B Ballantyne, Xiaoyang Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PBX1 genomic pioneer function drives ERα signaling underlying progression in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1002368"}], "href": "https://doi.org/10.1371/journal.pgen.1002368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22125492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22125492"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Kevin S Smith, Sumit K Chanda, Merel Lingbeek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(03)00277-6"}], "href": "https://doi.org/10.1016/s1097-2765(03"}, {"type": "t", "text": "00277-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14536079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14536079"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Richard Bayly, Luan Chuen, Richard A Currie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M408654200"}], "href": "https://doi.org/10.1074/jbc.M408654200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15507449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15507449"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Shane R Horman, Chinavenmeni S Velu, Aditya Chaubey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gfi1 integrates progenitor versus granulocytic transcriptional programming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-09-179747"}], "href": "https://doi.org/10.1182/blood-2008-09-179747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19346496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19346496"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "M Shimabe, S Goyama, N Watanabe-Okochi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.288"}], "href": "https://doi.org/10.1038/onc.2009.288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19767769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19767769"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Xin Xu, Kunkun Han, Xiaowen Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Ring Finger Protein RNF6 Induces Leukemia Cell Proliferation as a Direct Target of Pre-B-cell Leukemia Homeobox 1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.701979"}], "href": "https://doi.org/10.1074/jbc.M115.701979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26971355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26971355"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Luca Magnani, Darren K Patten, Van T M Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4243"}], "href": "https://doi.org/10.18632/oncotarget.4243"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26215677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26215677"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yan Liu, Xiaofeng Xu, Peng Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.006057"}], "href": "https://doi.org/10.1074/jbc.RA118.006057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30718275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30718275"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Joon T Park, Ie-Ming Shih, Tian-Li Wang "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-0517"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-0517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18974129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18974129"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Wen-Chieh Pi, Jun Wang, Miho Shimada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.2019003312"}], "href": "https://doi.org/10.1182/blood.2019003312"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32276273"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32276273"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Carla M Cuda, Shiwu Li, Shujuan Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pre-B cell leukemia homeobox 1 is associated with lupus susceptibility in mice and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1002362"}], "href": "https://doi.org/10.4049/jimmunol.1002362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22180614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22180614"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Xin Wei, Lili Yu, Yi Li "}, {"type": "b", "children": [{"type": "t", "text": "PBX1 promotes the cell proliferation via JAK2/STAT3 signaling in clear cell renal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.04.127"}], "href": "https://doi.org/10.1016/j.bbrc.2018.04.127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29678569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29678569"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Giovanna Casagrande, Geertruy te Kronnie, Giuseppe Basso "}, {"type": "b", "children": [{"type": "t", "text": "The effects of siRNA-mediated inhibition of E2A-PBX1 on EB-1 and Wnt16b expression in the 697 pre-B leukemia cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2006)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16769578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16769578"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "S Jiménez-Morales, E Miranda-Peralta, Y Saldaña-Alvarez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BCR-ABL, ETV6-RUNX1 and E2A-PBX1: prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.leukres.2008.03.021"}], "href": "https://doi.org/10.1016/j.leukres.2008.03.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18455790"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18455790"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Chiou-Hong Lin, Stephen Hon-Kit Wong, Jason H Kurzer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SETDB2 Links E2A-PBX1 to Cell-Cycle Dysregulation in Acute Leukemia through CDKN2C Repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2018.03.124"}], "href": "https://doi.org/10.1016/j.celrep.2018.03.124"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29694893"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29694893"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Richard Bayly, Takayuki Murase, Brandy D Hyndman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role for a single leucine residue in leukemia induction by E2A-PBX1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.02025-05"}], "href": "https://doi.org/10.1128/MCB.02025-05"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16914730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16914730"}]}]}]}