PCCB Gene

Name	propionyl CoA carboxylase, beta polypeptide
Description	The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPropionyl‐CoA carboxylase (PCC) is a mitochondrial, biotin‐dependent enzyme indispensable for the catabolism of branched‐chain amino acids, odd‐chain fatty acids, cholesterol, and related metabolites. Its enzymatic activity relies on a dodecameric holoenzyme composed of two distinct subunits. The PCCB gene encodes the beta subunit that furnishes the carboxyltransferase activity necessary for converting propionyl‐CoA to D-methylmalonyl–CoA. Mutational and expression analyses have demonstrated that alterations in PCCB disrupt this essential metabolic reaction and underlie the pathogenesis of propionic acidemia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nHigh‐resolution structural studies have revealed that the beta subunits assemble into a central hexameric core, around which the alpha subunits—responsible for the biotin carboxylase and carrier protein functions—are arrayed. This unique organization enforces spatial separation between the distinct catalytic sites, necessitating a considerable domain translocation during the catalytic cycle."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nExtensive genetic and functional investigations across diverse patient populations have identified a broad spectrum of pathogenic PCCB variants—including missense, nonsense, splicing defects, and small insertions/deletions—that compromise enzyme assembly, stability, or catalytic efficacy. These studies, utilizing biochemical assays and cellular expression systems, have been pivotal in establishing genotype–phenotype correlations in propionic acidemia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its well‐established role in intermediary metabolism, recent genome‐wide association studies have implicated the PCCB locus in influencing plasma lipoprotein profiles. Such findings suggest that genetic variation at the PCCB locus may have broader implications, potentially modulating cardiovascular risk and metabolic traits."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence from neurobiological studies further connects PCCB function with neural homeostasis. Downregulation of PCCB in human forebrain organoids has been shown to impair the tricarboxylic acid cycle, resulting in reduced gamma-aminobutyric acid (GABA) levels and altered neuronal network activity. These findings pave the way for linking PCCB deficiency not only to metabolic derangements seen in propionic acidemia but also to neuropsychiatric phenotypes such as features of autism spectrum disorders and schizophrenia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdvanced genomic techniques, including genome sequencing and transcript analysis, have further refined the molecular diagnosis of PCCB-related disorders by uncovering splicing defects and deep intronic variants. These integrative approaches enhance our understanding of the regulatory as well as coding regions of PCCB, ultimately informing improved diagnostic and therapeutic strategies for individuals affected by propionic acidemia."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "S Muro, B Pérez, L R Desviat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of PCCB gene mutations on the heteromeric and homomeric assembly of propionyl-CoA carboxylase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1006/mgme.2001.3254"}], "href": "https://doi.org/10.1006/mgme.2001.3254"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11749052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11749052"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Maja Chloupkova, Kenneth N Maclean, Asem Alkhateeb, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Propionic acidemia: analysis of mutant propionyl-CoA carboxylase enzymes expressed in Escherichia coli."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.10085"}], "href": "https://doi.org/10.1002/humu.10085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12007220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12007220"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "B Pérez, L R Desviat, P Rodríguez-Pombo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Propionic acidemia: identification of twenty-four novel mutations in Europe and North America."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1096-7192(02)00197-x"}], "href": "https://doi.org/10.1016/s1096-7192(02"}, {"type": "t", "text": "00197-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12559849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12559849"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "C Pérez-Cerdá, S Clavero, B Pérez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional analysis of PCCB mutations causing propionic acidemia based on expression studies in deficient human skin fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0925-4439(03)00039-5"}], "href": "https://doi.org/10.1016/s0925-4439(03"}, {"type": "t", "text": "00039-5) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12757933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12757933"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lourdes R Desviat, Sonia Clavero, Celia Perez-Cerdá, et al. "}, {"type": "b", "children": [{"type": "t", "text": "New splicing mutations in propionic acidemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10038-006-0068-3"}], "href": "https://doi.org/10.1007/s10038-006-0068-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17051315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17051315"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Christine S Huang, Kianoush Sadre-Bazzaz, Yang Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09302"}], "href": "https://doi.org/10.1038/nature09302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20725044"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20725044"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yen-Hui Chiu, Yu-Ning Liu, Wei-Ling Liao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two frequent mutations associated with the classic form of propionic acidemia in Taiwan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-014-9657-6"}], "href": "https://doi.org/10.1007/s10528-014-9657-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24863100"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24863100"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zhanling Chen, Pengqiang Wen, Guobing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Analysis of PCCA and PCCB gene mutations in patients with propionic acidemia]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.1003-9406.2015.01.006"}], "href": "https://doi.org/10.3760/cma.j.issn.1003-9406.2015.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25636094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25636094"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "M Stojiljkovic, K Klaassen, M Djordjevic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular and phenotypic characteristics of seven novel mutations causing branched-chain organic acidurias."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.12751"}], "href": "https://doi.org/10.1111/cge.12751"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26830710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26830710"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Deepti Gupta, Sunita Bijarnia-Mahay, Sudha Kohli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Seventeen Novel Mutations in PCCA and PCCB Genes in Indian Propionic Acidemia Patients, and Their Outcomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Test Mol Biomarkers (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/gtmb.2016.0017"}], "href": "https://doi.org/10.1089/gtmb.2016.0017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27227689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27227689"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ana Rivera-Barahona, Rosa Navarrete, Raquel García-Rodríguez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of 34 novel mutations in propionic acidemia: Functional characterization of missense variants and phenotype associations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2018.09.008"}], "href": "https://doi.org/10.1016/j.ymgme.2018.09.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30274917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30274917"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Olivia Wenger, Miraides Brown, Brandon Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biochemical phenotype and its relationship to treatment in 16 individuals with PCCB c.1606A > G (p.Asn536Asp) variant propionic acidemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2020.09.006"}], "href": "https://doi.org/10.1016/j.ymgme.2020.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33127324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33127324"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yao Chen, Xuehua Lin, Qingying Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene diagnosis and pedigree analysis of two Han ethnicity families with propionic acidemia in Fujian."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Medicine (Baltimore) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MD.0000000000024161"}], "href": "https://doi.org/10.1097/MD.0000000000024161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33725819"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33725819"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xiaoxuan Yang, Dongyan Li, Chaofeng Tu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel variants of the PCCB gene in Chinese patients with propionic acidemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Chim Acta (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cca.2021.03.019"}], "href": "https://doi.org/10.1016/j.cca.2021.03.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33798502"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33798502"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Daniel I Chasman, Guillaume Paré, Samia Mora, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A common benign intronic deletion masking a pathogenic deep intronic PCCB variant - genome sequencing and RNA studies to the rescue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2023.107702"}], "href": "https://doi.org/10.1016/j.ymgme.2023.107702"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37776842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37776842"}]}]}]}
Proteins	PCCB_HUMAN
NCBI Gene ID	5096
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PCCB has 7,904 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 128 datasets.

Click the + buttons to view associations for PCCB from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PCCB Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PCCB gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PCCB gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PCCB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PCCB gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PCCB gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PCCB gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PCCB gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PCCB gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PCCB gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PCCB gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PCCB protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PCCB gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCCB gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PCCB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PCCB gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with PCCB gene from the curated ClinVar Gene-Phenotype Associations dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PCCB gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PCCB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PCCB protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PCCB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PCCB protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PCCB gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PCCB gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PCCB gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PCCB gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PCCB gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving PCCB gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving PCCB gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PCCB gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PCCB gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PCCB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PCCB gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PCCB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PCCB gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PCCB protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PCCB gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCCB gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PCCB gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PCCB from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PCCB gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.