| HGNC Family | Cadherins |
| Name | protocadherin alpha 11 |
| Description | This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] |
| Summary |
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Genetic knockout models and in vitro studies have demonstrated that loss of OAT1 function leads to impaired renal clearance, altered plasma substrate levels, and consequent effects on drug efficacy and toxicity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in solute clearance, OAT1 is critically involved in mediating renal uptake of various nephrotoxicants—such as mercury complexes and cisplatin metabolites—which contributes to drug-induced and heavy metal–associated kidney injury. Its expression and function are finely regulated by transcription factors (for example, HNF1α/β), signaling kinases (like PKCζ), and even hormonal factors that underlie notable sex-dependent differences. Moreover, OAT1 can interact with certain organic cations under specific conditions, further influencing drug–drug interactions and tissue-specific susceptibilities."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMore recent systems biology and metabolomics studies have broadened the physiological significance of OAT1 by implicating it in remote sensing and signaling networks that coordinate interorgan as well as host–microbiome communication. These investigations reveal that OAT1 regulates key metabolic pathways—modulating tryptophan derivatives, lipids, bile acids, and uremic toxins—and may thereby influence chronic kidney disease progression and even neuronal function (e.g., impacting dendritic spine morphology in Alzheimer’s disease models). In addition, modulation of OAT1 activity by natural products and specific pharmacological agents highlights its potential as a therapeutic target to mitigate drug-induced toxicity and metabolic imbalances."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kunihiko Tanaka, Fanfan Zhou, Kogo Kuze, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M508050200"}], "href": "https://doi.org/10.1074/jbc.M508050200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16354673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16354673"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gregory Kaler, David M Truong, Akash Khandelwal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M703467200"}], "href": "https://doi.org/10.1074/jbc.M703467200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17553798"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17553798"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Takami Saji, Ryota Kikuchi, Hiroyuki Kusuhara, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M708615200"}], "href": "https://doi.org/10.1074/jbc.M708615200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18174163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18174163"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Scott A Barros, Chutima Srimaroeng, Jennifer L Perry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of protein kinase Czeta increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M808078200"}], "href": "https://doi.org/10.1074/jbc.M808078200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19028678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19028678"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sun-Young Ahn, Satish A Eraly, Igor Tsigelny, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of organic cations with organic anion transporters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.024489"}], "href": "https://doi.org/10.1074/jbc.M109.024489"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19737926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19737926"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jin-Sun Hwang, Eun-Young Park, Wan-Young Kim, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.139949"}], "href": "https://doi.org/10.1074/jbc.M110.139949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20921221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20921221"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "William R Wikoff, Megha A Nagle, Valentina L Kouznetsova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/pr200093w"}], "href": "https://doi.org/10.1021/pr200093w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21476605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21476605"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Adriana M Torres, Ankur V Dnyanmote, Kevin T Bush, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.249292"}], "href": "https://doi.org/10.1074/jbc.M111.249292"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21652719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21652719"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Davorka Breljak, Hrvoje Brzica, Douglas H Sweet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Renal Physiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajprenal.00201.2012"}], "href": "https://doi.org/10.1152/ajprenal.00201.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23389457"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23389457"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Xinlin Wu, Jianqing Zhang, Heng Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Organic Anion Transporter 1 Deficiency Accelerates Learning and Memory Impairment in tg2576 Mice by Damaging Dendritic Spine Morphology and Activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-015-0507-8"}], "href": "https://doi.org/10.1007/s12031-015-0507-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25725783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25725783"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wen-Hao Yu, Na Zhang, Jin-Feng Qi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2015/863971"}], "href": "https://doi.org/10.1155/2015/863971"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26788513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26788513"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Henry C Liu, Neema Jamshidi, Yuchen Chen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cts.12480"}], "href": "https://doi.org/10.1111/cts.12480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28689374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28689374"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Tianqiao Yong, Dan Li, Muxia Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Unique metabolite preferences of the drug transporters OAT1 and OAT3 analyzed by machine learning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.010729"}], "href": "https://doi.org/10.1074/jbc.RA119.010729"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31896576"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31896576"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Kevin T Bush, Prabhleen Singh, Sanjay K Nigam "}, {"type": "b", "children": [{"type": "t", "text": "Gut-derived uremic toxin handling in vivo requires OAT-mediated tubular secretion in chronic kidney disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.133817"}], "href": "https://doi.org/10.1172/jci.insight.133817"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32271169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32271169"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jeffry C Granados, Anne Richelle, Jahir M Gutierrez, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-28357-x"}], "href": "https://doi.org/10.1038/s41467-022-28357-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35169129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35169129"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Jeffry C Granados, Vladimir Ermakov, Koustav Maity, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The kidney drug transporter OAT1 regulates gut microbiome-dependent host metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.160437"}], "href": "https://doi.org/10.1172/jci.insight.160437"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36692015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36692015"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Vladimir S Ermakov, Jeffry C Granados, Sanjay K Nigam "}, {"type": "b", "children": [{"type": "t", "text": "Remote effects of kidney drug transporter OAT1 on gut microbiome composition and urate homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "JCI Insight (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/jci.insight.172341"}], "href": "https://doi.org/10.1172/jci.insight.172341"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37937647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37937647"}]}]}]}
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| Synonyms | CNRN7, CRNR7, CNRS7, CNR7, PCDH-ALPHA11 |
| Proteins | PCDAB_HUMAN |
| NCBI Gene ID | 56138 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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PCDHA11 has 2,495 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 62 datasets.
Click the + buttons to view associations for PCDHA11 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by PCDHA11 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PCDHA11 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of PCDHA11 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PCDHA11 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of PCDHA11 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PCDHA11 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCDHA11 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of PCDHA11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PCDHA11 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with PCDHA11 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of PCDHA11 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with PCDHA11 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with PCDHA11 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with PCDHA11 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by PCDHA11 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with PCDHA11 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PCDHA11 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with PCDHA11 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PCDHA11 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCDHA11 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of PCDHA11 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing PCDHA11 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with PCDHA11 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing PCDHA11 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PCDHA11 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of PCDHA11 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PCDHA11 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving PCDHA11 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing PCDHA11 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by PCDHA11 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of PCDHA11 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of PCDHA11 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PCDHA11 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with PCDHA11 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for PCDHA11 protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of PCDHA11 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of PCDHA11 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for PCDHA11 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for PCDHA11 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of PCDHA11 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of PCDHA11 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of PCDHA11 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PCDHA11 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with PCDHA11 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PCDHA11 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing PCDHA11 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain PCDHA11 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting PCDHA11 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of PCDHA11 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| PANTHER Pathways | pathways involving PCDHA11 protein from the PANTHER Pathways dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for PCDHA11 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PCDHA11 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving PCDHA11 protein from the Wikipathways PFOCR 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of PCDHA11 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PCDHA11 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of PCDHA11 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of PCDHA11 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of PCDHA11 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of PCDHA11 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PCDHA11 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of PCDHA11 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with PCDHA11 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
