PCGF1 Gene

HGNC Family	Zinc fingers
Name	polycomb group ring finger 1
Description	PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPCGF1 is a member of the Polycomb group proteins, a family of epigenetic chromatin modifiers crucial for governing stem cell fate and developmental gene regulation. As a defining component of a variant Polycomb Repressor Complex 1 (PRC1), PCGF1 interacts with co‐repressors such as BCOR and the histone demethylase KDM2B and associates with key pluripotency factors, thereby linking Polycomb-mediated transcriptional repression to the cellular circuitry controlling stemness and differentiation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "<br><br>\nIn the context of colorectal cancer, PCGF1 plays a pivotal role in maintaining a stem cell‐like phenotype. Elevated PCGF1 expression correlates with enhanced tumor progression by binding directly to the promoters of stem cell markers, modulating chromatin states through increased H3K4 trimethylation and decreased H3K27 trimethylation, and, in cooperation with interacting partners such as MORC4, reinforcing the transcriptional repression of key cell cycle inhibitors like CDKN1A"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "<br><br>\nIn ovarian cells relevant to polycystic ovary syndrome (PCOS), PCGF1 is targeted by microRNA‐320a. Experimental modulation in this setting indicates that PCGF1 overexpression suppresses insulin‐induced cell viability and colony formation while promoting apoptosis, suggesting that PCGF1 contributes to the fine‐tuning of cell proliferation and survival under hormonal influence"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "<br><br>\nStructural studies have illuminated that the integrity of the PCGF1 protein, and particularly its domain interactions with BCOR/BCORL1 and KDM2B, is critical for the stable assembly of the noncanonical PRC1.1 complex. Moreover, PCGF1 is implicated in epigenetic control mechanisms beyond stemness; for instance, it facilitates the deposition of ubiquitin on histone H2A at MHC class I promoters, thus contributing to the silencing of these genes and enabling immune evasion in tumor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Merel E Valk-Lingbeek, Sophia W M Bruggeman, Maarten van Lohuizen "}, {"type": "b", "children": [{"type": "t", "text": "Stem cells and cancer; the polycomb connection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2004.08.005"}], "href": "https://doi.org/10.1016/j.cell.2004.08.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15315754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15315754"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Giorgio Oliviero, Nayla Munawar, Ariane Watson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep18388"}], "href": "https://doi.org/10.1038/srep18388"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26687479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26687479"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Guangyu Ji, Wenjuan Zhou, Jingyi Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-03914-2"}], "href": "https://doi.org/10.1038/s41419-021-03914-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34148069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34148069"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yichao Liang, Di Wu, Qiao Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41417-023-00605-2"}], "href": "https://doi.org/10.1038/s41417-023-00605-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36932196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36932196"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lei Yang, Yan Li, Xiaojing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA‑320a inhibition decreases insulin‑induced KGN cell proliferation and apoptosis by targeting PCGF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2017.7270"}], "href": "https://doi.org/10.3892/mmr.2017.7270"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28849208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28849208"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sarah J Wong, Olga Senkovich, Jason A Artigas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure and Role of BCOR PUFD in Noncanonical PRC1 Assembly and Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.0c00285"}], "href": "https://doi.org/10.1021/acs.biochem.0c00285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32628469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32628469"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ruud H Wijdeven, Sietse J Luk, Tom A W Schoufour, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Balanced Epigenetic Regulation of MHC Class I Expression in Tumor Cells by the Histone Ubiquitin Modifiers BAP1 and PCGF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.2300263"}], "href": "https://doi.org/10.4049/jimmunol.2300263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38088808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38088808"}]}]}]}
Synonyms	RNF3A-2, RNF68, 2010002K04RIK, NSPC1
Proteins	PCGF1_HUMAN
NCBI Gene ID	84759
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PCGF1 has 5,249 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 106 datasets.

Click the + buttons to view associations for PCGF1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PCGF1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PCGF1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PCGF1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PCGF1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PCGF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PCGF1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PCGF1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PCGF1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PCGF1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PCGF1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PCGF1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PCGF1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PCGF1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PCGF1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PCGF1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCGF1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PCGF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PCGF1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PCGF1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PCGF1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PCGF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PCGF1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PCGF1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PCGF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PCGF1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing PCGF1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PCGF1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PCGF1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PCGF1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PCGF1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PCGF1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PCGF1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PCGF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PCGF1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PCGF1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PCGF1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCGF1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PCGF1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PCGF1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PCGF1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PCGF1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.