PCNX1 Gene

Name	pecanex 1
Description	This gene encodes an evolutionarily conserved transmembrane protein similar to the pecanex protein in Drosophila. The fly protein is a component of the Notch signaling pathway, which functions in several developmental processes. [provided by RefSeq, Jul 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent research has unveiled that PCNX1 (pecanex) exerts an oncogenic role in non‐small cell lung cancer (NSCLC) by acting as a competitive endogenous RNA (ceRNA) for S-phase kinase associated protein 2 (Skp2). PCNX1 achieves this regulation in a miRNA- and 3′ UTR-dependent manner, with several shared miRNAs (miR-26, miR-182, miR-340, and miR-506) mediating this interaction. In doing so, PCNX1’s 3′ UTR promotes cell growth, proliferation, and cell cycle progression, while concurrently suppressing apoptosis in lung cancer cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, mechanistic insights reveal that knockdown of PCNX1 impairs EGF-induced Akt phosphorylation—a key signaling event in cancer cell survival—the effect of which can be reversed by silencing Dicer, implying a critical role for the miRNA biogenesis machinery. In parallel, both PCNX1 and Skp2 are found to be coordinately upregulated in lung cancer tissues compared with adjacent non-tumor tissues, underscoring their potential as promising biomarkers and targets for therapeutic interventions in NSCLC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jingqiu Li, Haihua Tian, Jinchang Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pecanex functions as a competitive endogenous RNA of S-phase kinase associated protein 2 in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2017.07.030"}], "href": "https://doi.org/10.1016/j.canlet.2017.07.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28789966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28789966"}]}]}]}
NCBI Gene ID	22990
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PCNX1 has 2,712 functional associations with biological entities spanning 6 categories (chemical, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 30 datasets.

Click the + buttons to view associations for PCNX1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PCNX1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PCNX1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PCNX1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PCNX1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PCNX1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PCNX1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PCNX1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PCNX1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PCNX1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PCNX1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PCNX1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	GTEx eQTL 2025	SNPs regulating expression of PCNX1 gene from the GTEx eQTL 2025 dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of PCNX1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	GWAS Catalog SNP-Phenotype Associations 2025	phenotypes associated with PCNX1 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of PCNX1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Mouse Transcription Factor Targets 2025	transcription factors regulating expression of PCNX1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
	LINCS L1000 CMAP Chemical Perturbation Consensus Signatures	small molecule perturbations changing expression of PCNX1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
	MoTrPAC Rat Endurance Exercise Training	tissue samples with high or low expression of PCNX1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	drug perturbations changing expression of PCNX1 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
	PFOCR Pathway Figure Associations 2024	pathways involving PCNX1 protein from the Wikipathways PFOCR 2024 dataset.
	Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of PCNX1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
	Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of PCNX1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
	Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures	gene perturbations changing expression of PCNX1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of PCNX1 gene from the Rummagene Transcription Factor Associations 2026 dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of PCNX1 gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of PCNX1 gene from the RummaGEO Gene Perturbation Signatures dataset.
	Sci-Plex Drug Perturbation Signatures	drug perturbations changing expression of PCNX1 gene from the Sci-Plex Drug Perturbation Signatures dataset.
	Tahoe Therapeutics Tahoe 100M Perturbation Atlas	drug perturbations changing expression of PCNX1 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	tissues with high expression of PCNX1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Experimental Tissue Protein Expression Evidence Scores 2025	tissues with high expression of PCNX1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with PCNX1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.