{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent investigations into cancer‐associated genetic alterations have highlighted that mutations in genes containing coding mononucleotide repeats can drive tumorigenesis in a tissue‐ and context‐specific manner. One study systematically screened 33 such target genes in microsatellite instability‐high (MSI‐H) colorectal carcinomas, identifying frequent frameshift mutations in several candidates. Although this work did not identify PCNXL2 among the most frequently mutated genes in colorectal cancer, it underscores the importance of repetitive sequences in gene inactivation during tumor development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn a separate investigation focusing on thyroid cancer—the most common endocrine malignancy—a case–control study examined polymorphisms in PCNXL2. This study found that certain single nucleotide polymorphisms (SNPs) in PCNXL2, such as rs10910660, were associated with an increased risk of thyroid cancer, while others like rs12129938 and rs4649295 demonstrated protective effects, with age‐ and sex‐dependent variations in risk. These findings implicate PCNXL2 genetic variants as risk factors and suggest that the gene may modulate molecular pathways that predispose individuals to thyroid tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTogether, these studies imply that while PCNXL2 is not prominently altered by frameshift mutations in high‐instability colorectal tumors, its polymorphic variation plays a notable role in thyroid cancer susceptibility. This contrast suggests a tissue‐specific function for PCNXL2, where its genetic variability may affect cellular processes that underpin endocrine malignancy risk, making it a potential biomarker for thyroid cancer predisposition.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nam-Gyun Kim, Hwanseok Rhee, Long Shan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1205703"}], "href": "https://doi.org/10.1038/sj.onc.1205703"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12140758"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12140758"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Runmei Hao, Peng Han, Ling Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms in the "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PCNXL2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " gene are risk factors for thyroid cancer in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Future Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/fon-2021-0748"}], "href": "https://doi.org/10.2217/fon-2021-0748"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34747634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34747634"}]}]}]}