PCSK2 Gene

Name	proprotein convertase subtilisin/kexin type 2
Description	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPCSK2, also known as prohormone convertase 2 (PC2), is a calcium‐dependent endoproteolytic enzyme that plays a central role in the tissue‐specific conversion of inactive prohormones into active peptide hormones. Several studies have demonstrated that PCSK2 is responsible for cleaving a variety of propeptides—including proghrelin, prosomatostatin, and procholecystokinin (CCK)—thereby facilitating the generation of bioactive hormones that regulate neuroendocrine functions. Its expression is finely tuned by hormonal cues (for instance, thyroid hormone levels can suppress or stimulate its mRNA expression) and its activation is critically regulated by the chaperone protein 7B2, whose own modification (such as phosphorylation) can impact PCSK2 maturation and activity. These findings underscore the fundamental role of PCSK2 in orchestrating proper peptide processing in both neuronal and endocrine cell types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic and clinical studies have further implicated PCSK2 variants in metabolic regulation and the pathogenesis of type 2 diabetes mellitus. Polymorphisms in the PCSK2 gene have been associated with impaired proinsulin processing, altered fasting glucose and insulin levels, and an increased risk of diabetes in diverse populations. In addition, aberrant PCSK2 expression patterns—such as its unusual appearance in pancreatic β‐cells under diabetic conditions—suggest that dysregulation of its convertase activity may negatively affect glucose homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in hormone activation and metabolic control, the tissue‐specific expression of PCSK2 adds a valuable dimension to disease diagnosis and characterization. Elevated or diminished levels of PCSK2 have been reported in various neoplasms—such as neuroendocrine tumors and ACTH‐secreting lesions—where its expression can help indicate tumor origin and differentiation. Similarly, altered expression in the human retina, optic nerve head, and hypothalamic regions (as observed in neurodegenerative disorders like Huntington disease) highlights the broad physiological impact of PCSK2 and its potential as a biomarker in both oncologic and neurologic contexts. Furthermore, emerging studies have linked members of the proprotein convertase family to tumorigenesis, suggesting that PCSK2 may also have roles in cancer biology."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "L J Deftos, D Burton, R H Hastings, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparative tissue distribution of the processing enzymes \"prohormone thiol protease,\" and prohormone convertases 1 and 2, in human PTHrP-producing cell lines and mammalian neuroendocrine tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrine (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1385/endo:15:2:217"}], "href": "https://doi.org/10.1385/endo:15:2:217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11720250"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11720250"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "R Winsky-Sommerer, D Grouselle, C Rougeot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0306-4522(03)00560-8"}], "href": "https://doi.org/10.1016/s0306-4522(03"}, {"type": "t", "text": "00560-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14614908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14614908"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaoxiong Shen, Qiao-Ling Li, Gregory A Brent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of regional expression in rat brain PC2 by thyroid hormone/characterization of novel negative thyroid hormone response elements in the PC2 promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00144.2004"}], "href": "https://doi.org/10.1152/ajpendo.00144.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15585599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15585599"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jens F Rehfeld, Jens R Bundgaard, Jens Hannibal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cell-specific pattern of cholecystokinin peptides in endocrine cells versus neurons is governed by the expression of prohormone convertases 1/3, 2, and 5/6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2007-0278"}], "href": "https://doi.org/10.1210/en.2007-0278"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18096669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18096669"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tomoko Takahashi, Takanori Ida, Takahiro Sato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvp112"}], "href": "https://doi.org/10.1093/jb/mvp112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19628676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19628676"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Bruno Ramos-Molina, Iris Lindberg "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone Convertase 2 Activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2014-1394"}], "href": "https://doi.org/10.1210/me.2014-1394"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25811241"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25811241"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tennille S Leak, Keith L Keene, Carl D Langefeld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of the proprotein convertase subtilisin/kexin-type 2 (PCSK2) gene with type 2 diabetes in an African American population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2007.05.014"}], "href": "https://doi.org/10.1016/j.ymgme.2007.05.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17618154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17618154"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xiaoya Zheng, Wei Ren, Suhua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-011-0705-6"}], "href": "https://doi.org/10.1007/s11033-011-0705-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21437630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21437630"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "A Jonsson, B Isomaa, T Tuomi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of a common variant of the PCSK2 gene on reduced insulin secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetologia (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00125-012-2728-5"}], "href": "https://doi.org/10.1007/s00125-012-2728-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23011353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23011353"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Tien-Jyun Chang, Yen-Feng Chiu, Wayne H-H Sheu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep14380"}], "href": "https://doi.org/10.1038/srep14380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26607656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26607656"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Adam Ramzy, Ali Asadi, Timothy J Kieffer "}, {"type": "b", "children": [{"type": "t", "text": "Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db19-0276"}], "href": "https://doi.org/10.2337/db19-0276"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32291281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32291281"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "George N Tzimas, Eric Chevet, Sarah Jenna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abnormal expression and processing of the proprotein convertases PC1 and PC2 in human colorectal liver metastases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-5-149"}], "href": "https://doi.org/10.1186/1471-2407-5-149"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16293189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16293189"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "John A Fuller, Anne-Marie Brun-Zinkernagel, Abbot F Clark, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.08-2616"}], "href": "https://doi.org/10.1167/iovs.08-2616"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19339735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19339735"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yuji Tani, Toru Sugiyama, Hajime Izumiyama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential gene expression profiles of POMC-related enzymes, transcription factors and receptors between non-pituitary and pituitary ACTH-secreting tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1507/endocrj.k10e-389"}], "href": "https://doi.org/10.1507/endocrj.k10e-389"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21383526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21383526"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Daniel J van Wamelen, N Ahmad Aziz, Juan Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased hypothalamic prohormone convertase expression in huntington disease patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neuropathol Exp Neurol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/NEN.0000000000000010"}], "href": "https://doi.org/10.1097/NEN.0000000000000010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24226266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24226266"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Satu Maria Remes, Helena Leijon, Tiina Vesterinen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "APMIS (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/apm.13071"}], "href": "https://doi.org/10.1111/apm.13071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32794589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32794589"}]}]}]}
Synonyms	SPC2, NEC-2, NEC2, NEC 2
Proteins	NEC2_HUMAN
NCBI Gene ID	5126
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PCSK2 has 4,950 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for PCSK2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PCSK2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PCSK2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PCSK2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PCSK2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PCSK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PCSK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PCSK2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PCSK2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PCSK2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PCSK2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PCSK2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PCSK2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PCSK2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PCSK2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCSK2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PCSK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PCSK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PCSK2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PCSK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PCSK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PCSK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PCSK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PCSK2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PCSK2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PCSK2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PCSK2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PCSK2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PCSK2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PCSK2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PCSK2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PCSK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PCSK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PCSK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PCSK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PCSK2 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PCSK2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCSK2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PCSK2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PCSK2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PCSK2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PCSK2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.