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This nuanced ligand–receptor interaction results in a more dynamic modulation of the immune response, as PD‐L2 is expressed on select antigen‐presenting cells and, in certain pathological states, on malignant cells, where its engagement contributes to T‐cell exhaustion and immune evasion in chronic infections and cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn clinical settings, aberrant expression and genomic amplification of PDCD1LG2 are increasingly recognized as key mechanisms of tumor immune escape and poor patient prognosis. Elevated PD‐L2 levels have been reported in multiple malignancies—including Hodgkin and non‐Hodgkin lymphomas, esophageal, breast, renal, and other solid tumors—where they correlate with aggressive disease phenotypes and resistance to standard therapies. 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