{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPDCD6IP, also known as ALIX, functions as a central adaptor in the endosomal sorting complexes required for transport (ESCRT) machinery that drives the biogenesis of exosomes and multivesicular bodies. In this role, ALIX interacts with transmembrane proteoglycans (such as syndecans) and their cytosolic partner syntenin to coordinate the inward budding of endosomal membranes and selective loading of signaling cargo (e.g. FGFs and PD‐L1) into exosomes. These interactions are further modulated by unconventional lipids, such as lysobisphosphatidic acid (LBPA), which together with ALIX ensure proper receptor trafficking and even contribute to immunomodulatory processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in vesicle biogenesis, PDCD6IP/ALIX is critically involved in executing membrane remodeling events during cytokinesis and in the budding of enveloped viruses. At the midbody, ALIX is recruited via interactions with centrosomal proteins (for example, CEP55) and ESCRT components such as Tsg101 and CHMP4 isoforms to mediate abscission—the final scission step that separates daughter cells. 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