PDE10A Gene

HGNC Family	Phosphodiesterases (PDE)
Name	phosphodiesterase 10A
Description	The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPhosphodiesterase 10A (PDE10A) is a dual‐specificity enzyme that hydrolyzes both cAMP and cGMP and is highly enriched in striatal medium spiny neurons, where it plays a pivotal role in fine‐tuning intracellular cyclic nucleotide signaling. Genetic studies have revealed that copy number variants in the PDE10A gene are linked to neuropsychiatric conditions such as schizophrenia"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", and genome‐wide association data suggest that PDE10A variants may also be associated with endocrine parameters including thyroid stimulating hormone levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the nervous system, precise regulation of PDE10A activity is critical for motor control and cognitive functions. Mutations affecting the regulatory GAF‐B domain of PDE10A, which normally binds cAMP to enhance enzymatic activity, have been identified in patients with childhood‐onset chorea and hyperkinetic movement disorders"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Moreover, alterations in PDE10A expression or function have been implicated in neurodegenerative disorders such as Huntington disease, where in vivo PET imaging and postmortem studies point to dysregulation of striatal PDE10A in disease progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and even in conditions of aberrant purine metabolism linked to Lesch-Nyhan disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent insights have further expanded our understanding of PDE10A’s molecular complexity. A primate-specific transcript, PDE10A19, has been identified that generates an isoform with a unique N terminus and distinct subcellular distribution – interacting with other PDE10A isoforms to modulate their plasma membrane localization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In addition, detailed biochemical studies of its regulatory GAF domain have shown that PDE10A binds cAMP with nanomolar affinity, highlighting the precision of its regulatory mechanisms."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond the central nervous system, emerging evidence implicates PDE10A in diverse physiological processes. In an evolutionary context, natural selection on PDE10A variants in the Bajau people has been linked to increased spleen size, providing an enhanced reservoir of oxygenated red blood cells and offering an adaptive advantage in hypoxic conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In the realm of oncology, PDE10A is overexpressed in colon tumor cells, and its inhibition suppresses tumor cell growth, suggesting a novel role in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Finally, the enzyme’s antigenicity has been exploited to develop antibody biomarkers for paraneoplastic neurological autoimmunity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", while PDE10A expression in brown adipose tissue has been shown to influence thermogenesis and energy expenditure, with implications for obesity and diabetes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these findings underscore the multifaceted functions of PDE10A in both neuronal and peripheral tissues. Its strict regulation by post-translational modifications such as protein kinase A phosphorylation and palmitoylation orchestrates its subcellular trafficking and localization, thereby influencing cyclic nucleotide signaling pathways that underpin motor control, neurodegeneration, metabolic homeostasis, and even cancer biology. The emerging insights into PDE10A’s genetic diversity, isoform-specific roles, and signaling mechanisms continue to identify this enzyme as a promising diagnostic biomarker and therapeutic target across a wide spectrum of clinical conditions.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gloria W C Tam, Louie N van de Lagemaat, Richard Redon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Confirmed rare copy number variants implicate novel genes in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Soc Trans (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BST0380445"}], "href": "https://doi.org/10.1042/BST0380445"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20298200"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20298200"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lisette Arnaud-Lopez, Gianluca Usala, Graziano Ceresini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2008.04.019"}], "href": "https://doi.org/10.1016/j.ajhg.2008.04.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18514160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18514160"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Niccolò E Mencacci, Erik-Jan Kamsteeg, Kosuke Nakashima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2016.02.015"}], "href": "https://doi.org/10.1016/j.ajhg.2016.02.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27058447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27058447"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Christine P Diggle, Stacey J Sukoff Rizzo, Michael Popiolek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2016.03.015"}], "href": "https://doi.org/10.1016/j.ajhg.2016.03.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27058446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27058446"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rawaha Ahmad, Sophie Bourgeois, Andrey Postnov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PET imaging shows loss of striatal PDE10A in patients with Huntington disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000000037"}], "href": "https://doi.org/10.1212/WNL.0000000000000037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24353339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24353339"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "David S Russell, Danna L Jennings, Olivier Barret, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Change in PDE10 across early Huntington disease assessed by [18F]MNI-659 and PET imaging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000002391"}], "href": "https://doi.org/10.1212/WNL.0000000000002391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26802091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26802091"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yiqian Chen, Margaret G Gall, Hui Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2016.02.020"}], "href": "https://doi.org/10.1016/j.yexcr.2016.02.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26930324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26930324"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "C M MacMullen, K Vick, R Pacifico, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/tp.2016.3"}], "href": "https://doi.org/10.1038/tp.2016.3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26905414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26905414"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Karina Matthiesen, Jacob Nielsen "}, {"type": "b", "children": [{"type": "t", "text": "Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20090982"}], "href": "https://doi.org/10.1042/BJ20090982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19689430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19689430"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Melissa A Ilardo, Ida Moltke, Thorfinn S Korneliussen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Physiological and Genetic Adaptations to Diving in Sea Nomads."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2018.03.054"}], "href": "https://doi.org/10.1016/j.cell.2018.03.054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29677510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29677510"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "N Li, K Lee, Y Xi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.94"}], "href": "https://doi.org/10.1038/onc.2014.94"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24704829"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24704829"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Anastasia Zekeridou, Thomas Kryzer, Yong Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphodiesterase 10A IgG: A novel biomarker of paraneoplastic neurologic autoimmunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0000000000007971"}], "href": "https://doi.org/10.1212/WNL.0000000000007971"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31315972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31315972"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mohammed K Hankir, Mathias Kranz, Thorsten Gnad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel thermoregulatory role for PDE10A in mouse and human adipocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.201506085"}], "href": "https://doi.org/10.15252/emmm.201506085"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27247380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27247380"}]}]}]}
Synonyms	ADSD2, PDE10A19, IOLOD, HSPDE10A, LINC00473
Proteins	PDE10_HUMAN
NCBI Gene ID	10846
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PDE10A has 10,901 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 121 datasets.

Click the + buttons to view associations for PDE10A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PDE10A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE10A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE10A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PDE10A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PDE10A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PDE10A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE10A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PDE10A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDE10A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDE10A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PDE10A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDE10A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PDE10A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PDE10A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDE10A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PDE10A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PDE10A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PDE10A gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PDE10A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PDE10A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PDE10A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PDE10A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDE10A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PDE10A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PDE10A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PDE10A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PDE10A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PDE10A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PDE10A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PDE10A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PDE10A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PDE10A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PDE10A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PDE10A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PDE10A protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PDE10A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDE10A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PDE10A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PDE10A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PDE10A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PDE10A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.