PDE11A Gene

HGNC Family	Phosphodiesterases (PDE)
Name	phosphodiesterase 11A
Description	The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPhosphodiesterase 11A (PDE11A) is a member of the cyclic nucleotide phosphodiesterase family that hydrolyzes cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), thereby finely tuning intracellular signaling. Multiple splice variants exist, with PDE11A4 being the prominent isoform detected in various human tissues. Investigations into its biochemical properties have revealed that the non‐catalytic GAF domains, especially the GAFa region, bind cGMP with high affinity and that modifications of its N‐terminal region can markedly alter cyclic nucleotide responsiveness, underscoring its role as a key regulator of cyclic nucleotide levels in a tissue‐ and context‐dependent manner."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies have implicated PDE11A in endocrine pathophysiology, particularly within the adrenal cortex. Inactivating and missense mutations in PDE11A have been associated with micronodular adrenocortical hyperplasia, Cushing syndrome, and other adrenal tumors, with evidence also pointing toward its involvement in Carney complex. These alterations appear to disrupt normal cAMP signaling in steroidogenic tissues, thereby predisposing carriers to a spectrum of endocrine abnormalities."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond adrenal disorders, PDE11A genetic variants have been linked to gonadal pathology. Inactivating mutations and functionally deleterious missense substitutions in the PDE11A gene have been identified in patients with testicular germ cell tumors (TGCT) and familial testicular cancer. These variants compromise enzyme activity, leading to increased cyclic nucleotide levels that may, in turn, affect cellular proliferation and tumorigenesis in reproductive tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThere is also evidence for a neuromodulatory role of PDE11A in mood regulation and other brain functions. Initial studies associated PDE11A gene variants and specific haplotypes with major depressive disorder (MDD) and antidepressant treatment response. However, subsequent replication studies have yielded largely negative findings regarding treatment outcome. More recently, rare PDE11A missense mutations have been linked to early‐onset Alzheimer’s disease, with functional studies indicating that altered PDE11A activity may lead to increased cAMP levels, activation of protein kinase A, and subsequent Tau hyperphosphorylation, thereby suggesting its broader neurobiological significance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional tissue‐specific roles for PDE11A have been observed. PDE11A protein expression has been documented in the human prostate glandular epithelium and has been noted to be down‐regulated in prostate cancer, implying a potential role in modulating local cyclic nucleotide signaling. Furthermore, immunohistochemical studies in clitoral tissue have detected PDE11A immunoreactivity in nerve trunks, suggesting its participation in local neuro-transmission within reproductive organs. Finally, emerging data also point to associations of PDE11A variants with altered blood pressure regulation and somatotroph adenomas, reinforcing the enzyme’s pleiotropic roles across diverse physiological systems."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "K Loughney, J Taylor, V A Florio "}, {"type": "b", "children": [{"type": "t", "text": "3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Impot Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.ijir.3901317"}], "href": "https://doi.org/10.1038/sj.ijir.3901317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15800651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15800651"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Karina Matthiesen, Jacob Nielsen "}, {"type": "b", "children": [{"type": "t", "text": "Binding of cyclic nucleotides to phosphodiesterase 10A and 11A GAF domains does not stimulate catalytic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20090982"}], "href": "https://doi.org/10.1042/BJ20090982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19689430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19689430"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marco Gross-Langenhoff, Arnulf Stenzl, Florian Altenberend, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2008.06319.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2008.06319.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18312413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18312413"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Anelia Horvath, Christoforos Giatzakis, Audrey Robinson-White, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adrenal hyperplasia and adenomas are associated with inhibition of phosphodiesterase 11A in carriers of PDE11A sequence variants that are frequent in the population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-06-2914"}], "href": "https://doi.org/10.1158/0008-5472.CAN-06-2914"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17178847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17178847"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Rossella Libé, Amato Fratticci, Joel Coste, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphodiesterase 11A (PDE11A) and genetic predisposition to adrenocortical tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-08-0106"}], "href": "https://doi.org/10.1158/1078-0432.CCR-08-0106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18559625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18559625"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rossella Libé, Anelia Horvath, Delphine Vezzosi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent phosphodiesterase 11A gene (PDE11A) defects in patients with Carney complex (CNC) caused by PRKAR1A mutations: PDE11A may contribute to adrenal and testicular tumors in CNC as a modifier of the phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2010-1704"}], "href": "https://doi.org/10.1210/jc.2010-1704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21047926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21047926"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "S A Boikos, A Horvath, S Heyerdahl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphodiesterase 11A expression in the adrenal cortex, primary pigmented nodular adrenocortical disease, and other corticotropin-independent lesions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Horm Metab Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/s-2008-1076694"}], "href": "https://doi.org/10.1055/s-2008-1076694"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18491255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18491255"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Eirini I Bimpaki, Maria Nesterova, Constantine A Stratakis "}, {"type": "b", "children": [{"type": "t", "text": "Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Endocrinol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/EJE-09-0027"}], "href": "https://doi.org/10.1530/EJE-09-0027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19429701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19429701"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Delphine Vezzosi, Rossella Libé, Camille Baudry, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphodiesterase 11A (PDE11A) gene defects in patients with acth-independent macronodular adrenal hyperplasia (AIMAH): functional variants may contribute to genetic susceptibility of bilateral adrenal tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2012-2275"}], "href": "https://doi.org/10.1210/jc.2012-2275"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22996146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22996146"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Anelia Horvath, Larissa Korde, Mark H Greene, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-0884"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-0884"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19549888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19549888"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Anand Pathak, Douglas R Stewart, Fabio R Faucz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rare inactivating PDE11A variants associated with testicular germ cell tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Relat Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/ERC-15-0034"}], "href": "https://doi.org/10.1530/ERC-15-0034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26459559"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26459559"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "F Faja, F Finocchi, T Carlini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDE11A gene polymorphism in testicular cancer: sperm parameters and hormonal profile."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Endocrinol Invest (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s40618-021-01534-3"}], "href": "https://doi.org/10.1007/s40618-021-01534-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33661511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33661511"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ma-Li Wong, Fiona Whelan, Panagiotis Deloukas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0602795103"}], "href": "https://doi.org/10.1073/pnas.0602795103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17008408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17008408"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Roy H Perlis, Bonnie Fijal, Sweta Dharia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2009.12.010"}], "href": "https://doi.org/10.1016/j.biopsych.2009.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20110084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20110084"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Michael Cabanero, Gonzalo Laje, Sevilla Detera-Wadleigh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0b013e328320a3e2"}], "href": "https://doi.org/10.1097/FPC.0b013e328320a3e2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19214142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19214142"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Huai-Rong Luo, Gui-Sheng Wu, Chuanhui Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of PDE11A global haplotype with major depression and antidepressant drug response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropsychiatr Dis Treat (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/ndt.s4771"}], "href": "https://doi.org/10.2147/ndt.s4771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19557111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19557111"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wei Qin, Aihong Zhou, Xiumei Zuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing revealed PDE11A as a novel candidate gene for early-onset Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddab090"}], "href": "https://doi.org/10.1093/hmg/ddab090"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33835157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33835157"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Fabio Rueda Faucz, Anelia Horvath, Anya Rothenbuhler, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Analysis of genetic variants of phosphodiesterase 11A in acromegalic patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Endocrinol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/EJE-09-0677"}], "href": "https://doi.org/10.1530/EJE-09-0677"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19671705"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19671705"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Therese Ohlsson, Arne Lindgren, Gunnar Engström, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A stop-codon of the phosphodiesterase 11A gene is associated with elevated blood pressure and measures of obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hypertens (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/HJH.0000000000000821"}], "href": "https://doi.org/10.1097/HJH.0000000000000821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26820475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26820475"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "S Ückert, M Oelke, K Albrecht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and distribution of key enzymes of the cyclic GMP signaling in the human clitoris: relation to phosphodiesterase type 5 (PDE5)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Impot Res (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ijir.2011.29"}], "href": "https://doi.org/10.1038/ijir.2011.29"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21697861"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21697861"}]}]}]}
Synonyms	PPNAD2
Proteins	PDE11_HUMAN
NCBI Gene ID	50940
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PDE11A has 5,466 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 133 datasets.

Click the + buttons to view associations for PDE11A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PDE11A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PDE11A gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE11A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE11A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PDE11A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PDE11A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PDE11A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE11A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PDE11A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDE11A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDE11A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PDE11A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDE11A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PDE11A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PDE11A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDE11A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PDE11A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PDE11A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with PDE11A gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PDE11A gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PDE11A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PDE11A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PDE11A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PDE11A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PDE11A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PDE11A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDE11A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PDE11A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PDE11A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PDE11A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PDE11A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PDE11A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for PDE11A protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving PDE11A gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving PDE11A gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PDE11A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PDE11A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PDE11A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PDE11A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PDE11A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PDE11A protein from the curated DrugBank Drug Targets dataset.