{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA review of the provided abstracts reveals a broad investigation into the roles of C/EBP family transcription factors in regulating diverse biological processes—including tumor‐induced immunosuppression, adipogenesis, ovulation, emergency granulopoiesis, cardiac remodeling, metabolism, fibrosis, and tissue regeneration—but none of these studies directly mention or characterize PDE4C. In other words, while these reports extensively delineate C/EBPβ (and related isoforms) as pivotal regulators of cell proliferation, differentiation, stress responses, and inflammatory signaling, they do not provide any insights into the function or signaling mechanisms of PDE4C."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFor context, PDE4C is one isoform of the phosphodiesterase 4 family that hydrolyzes cyclic adenosine monophosphate (cAMP) and thereby modulates intracellular signaling cascades—including those that can regulate transcription factors such as the C/EBP proteins. Although this enzyme’s functional role is well established in other systems as a modulator of cAMP‐dependent pathways (affecting inflammation, metabolism, and cell differentiation), none of the abstracts under review address its specific contributions. The studies instead concentrate on the C/EBP family’s direct transcriptional control in processes ranging from adipocyte differentiation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "to mediating stress and inflammatory responses in various tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, while the corpus of literature provided offers rich insight into the transcriptional networks governed by C/EBP factors, it does not include any discussion on PDE4C. Thus, based on these abstracts there is no evidence to elucidate a direct functional role for PDE4C—even though, by extrapolation from broader cellular signaling studies, PDE4C may influence cAMP dynamics that could in turn modulate transcription factor activity in similar biological contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "40"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Songyun Zhu, Kyungsil Yoon, Esta Sterneck, et al. 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