PDE7A Gene

HGNC Family	Phosphodiesterases (PDE)
Name	phosphodiesterase 7A
Description	The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPDE7A isoforms are widely expressed in a range of human cell types implicated in inflammatory and immune responses. For example, PDE7A1 and PDE7A2 are found in T lymphocytes, monocytes, airway and vascular smooth muscle cells, lung fibroblasts, and epithelial cells, with expression patterns paralleling those of PDE4 and suggesting that PDE7A contributes to inflammatory signaling in conditions such as chronic obstructive pulmonary disease and asthma. In human T cells, selective inhibition of PDE7A can suppress cytokine synthesis, cell proliferation, and activation marker expression, underscoring its critical role in regulating immune function. In addition, altered PDE7A mRNA expression in sepsis models correlates with changes in key immune regulators, pointing to its involvement in modulating the inflammatory cascade."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural and biochemical studies have provided critical insights into PDE7A’s catalytic properties and pharmacological targeting. The crystal structure of the PDE7A1 catalytic domain complexed with a non‐selective inhibitor revealed that the precise conformation of a key invariant glutamine, along with the specific character of surrounding binding pocket residues, is essential for inhibitor selectivity. Complementary kinetic analyses demonstrated that PDE7A1 efficiently hydrolyzes cyclic cytidine monophosphate (cCMP) at high velocity and low affinity, distinguishing its enzymatic profile from other phosphodiesterases. Furthermore, the discovery of selective compounds such as BC54—targeting both PDE4 and PDE7—highlights the potential of modulating PDE7A activity for therapeutic benefits."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in immune regulation, PDE7A significantly influences cellular differentiation and neuroprotection in diverse tissues. In the central nervous system, expression of PDE7A in oligodendrocyte precursor cells modulates their survival and differentiation through ERK signaling, suggesting a role in remyelination strategies for demyelinating diseases such as multiple sclerosis. In models of Parkinson’s disease, PDE7A is upregulated in degenerating dopaminergic neurons and activated microglia, implicating its contribution to neurodegenerative and inflammation‐mediated brain damage. In the bone, PDE7A silencing in osteoblasts enhances the expression of osteogenic genes and promotes mineralization, indicating a regulatory function in bone formation. Moreover, PDE7A regulation by noncoding RNAs in sepsis models affects cell viability and injury responses, and its enriched expression in the medial habenula hints at a possible role in the pathophysiology of depression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Susan J Smith, Steven Brookes-Fazakerley, Louise E Donnelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00170.2002"}], "href": "https://doi.org/10.1152/ajplung.00170.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12388353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12388353"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "A Nakata, K Ogawa, T Sasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Immunol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.1365-2249.2002.01856.x"}], "href": "https://doi.org/10.1046/j.1365-2249.2002.01856.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12067300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12067300"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Christophe Lelubre, Hayfa Medfai, Israa Akl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leukocyte phosphodiesterase expression after lipopolysaccharide and during sepsis and its relationship with HLA-DR expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.5A0516-240R"}], "href": "https://doi.org/10.1189/jlb.5A0516-240R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28356347"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28356347"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Huanchen Wang, Yudong Liu, Yuxiang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M504398200"}], "href": "https://doi.org/10.1074/jbc.M504398200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15994308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15994308"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maike Monzel, Maike Kuhn, Heike Bähre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDE7A1 hydrolyzes cCMP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2014.08.005"}], "href": "https://doi.org/10.1016/j.febslet.2014.08.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25128584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25128584"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ana Santos de Medeiros, Arlene R Wyman, Manal A Alaamery, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2017.08.011"}], "href": "https://doi.org/10.1016/j.cellsig.2017.08.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28867658"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28867658"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "E M Medina-Rodríguez, F J Arenzana, J Pastor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of endogenous phosphodiesterase 7 promotes oligodendrocyte precursor differentiation and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-013-1340-2"}], "href": "https://doi.org/10.1007/s00018-013-1340-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23661015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23661015"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jose A Morales-Garcia, Sandra Alonso-Gil, Ángel Santos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-019-01745-z"}], "href": "https://doi.org/10.1007/s12035-019-01745-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31473904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31473904"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Minna Pekkinen, Mikael E B Ahlström, Ulrike Riehle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of phosphodiesterase 7 inhibition by RNA interference on the gene expression and differentiation of human mesenchymal stem cell-derived osteoblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2008.02.021"}], "href": "https://doi.org/10.1016/j.bone.2008.02.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18420479"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18420479"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Xinliang Zhang, Shimin Dong "}, {"type": "b", "children": [{"type": "t", "text": "Circ_0091702 relieves lipopolysaccharide (LPS)-induced cell injury by regulating the miR-182/PDE7A axis in sepsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Biotechnol Biochem (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/bbb/zbab100"}], "href": "https://doi.org/10.1093/bbb/zbab100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34077501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34077501"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lyubomir I Aftanas, Elena A Filimonova, Maksim S Anisimenko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The habenular volume and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "PDE7A"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " allelic polymorphism in major depressive disorder: preliminary findings."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Biol Psychiatry (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15622975.2022.2086297"}], "href": "https://doi.org/10.1080/15622975.2022.2086297"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35673941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35673941"}]}]}]}
Synonyms	PDE7
Proteins	PDE7A_HUMAN
NCBI Gene ID	5150
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PDE7A has 5,410 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for PDE7A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PDE7A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PDE7A gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE7A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE7A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PDE7A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PDE7A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE7A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDE7A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDE7A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PDE7A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PDE7A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDE7A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PDE7A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PDE7A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PDE7A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PDE7A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PDE7A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PDE7A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDE7A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PDE7A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PDE7A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PDE7A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PDE7A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PDE7A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PDE7A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PDE7A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PDE7A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PDE7A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PDE7A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PDE7A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PDE7A protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PDE7A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDE7A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PDE7A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PDE7A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with PDE7A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PDE7A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PDE7A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PDE7A from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of PDE7A gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of PDE7A gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.