PDE8B Gene

HGNC Family	Phosphodiesterases (PDE)
Name	phosphodiesterase 8B
Description	The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPhosphodiesterase 8B (PDE8B) is a high‐affinity, cyclic AMP (cAMP)–specific phosphodiesterase that plays a central role in endocrine regulation. In the thyroid, PDE8B modulates intracellular cAMP levels to influence thyroid hormone synthesis and secretion, with genetic variants correlating strongly with altered circulating thyroid‐stimulating hormone (TSH) levels. This regulation is critical because even subtle changes in cAMP can affect the feedback control mechanisms governing T4 and T3 production, highlighting PDE8B as a potential therapeutic target for thyroid dysfunction."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in thyroid physiology, PDE8B has been implicated in adrenal function. Mutations that impair PDE8B activity are associated with bilateral adrenocortical hyperplasia and corticotropin‐independent Cushing syndrome—a consequence of perturbed cAMP degradation in adrenal tissues. These findings reinforce the concept that PDE8B‐mediated control of cAMP is essential not only for thyroid hormone homeostasis but also for proper adrenal steroidogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the brain, PDE8B exhibits prominent expression in regions such as the hippocampus, with increased mRNA levels observed in cortical areas during the progression of Alzheimer’s disease. Moreover, rare, pathogenic mutations in PDE8B have been identified as the cause of autosomal‐dominant striatal degeneration—a movement disorder characterized by parkinsonism. Although investigation into its role in Parkinson’s disease has not established PDE8B mutations as a common causative factor, these studies underscore the broader importance of PDE8B in maintaining proper cAMP signaling within the central nervous system."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMolecular analyses of the PDE8B gene have revealed a complex structure with multiple splice variants that display tissue‐specific expression patterns. The full‐length isoform, PDE8B1, is predominantly expressed in thyroid tissue, whereas alternative splice forms appear in the brain and other tissues, including the testis where PDE8B may contribute to Leydig cell transformation. This diversity allows for fine‐tuned regulation of the cAMP signal in different cellular environments, reflecting the enzyme’s versatile role in both endocrine and nonendocrine contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, population studies have linked PDE8B polymorphisms not only with variations in TSH and thyroid hormone levels—in conditions such as subclinical hypothyroidism and hyperthyroxinemia—but also with broader metabolic and cardiovascular risks. In pregnant women and in distinct ethnic cohorts, variations in PDE8B are emerging as significant biomarkers that could inform both the diagnosis and treatment of subtle thyroid disturbances and their systemic consequences."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lisette Arnaud-Lopez, Gianluca Usala, Graziano Ceresini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2008.04.019"}], "href": "https://doi.org/10.1016/j.ajhg.2008.04.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18514160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18514160"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Michiko Gamanuma, Keizo Yuasa, Takashi Sasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0898-6568(02)00146-8"}], "href": "https://doi.org/10.1016/s0898-6568(02"}, {"type": "t", "text": "00146-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12681444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12681444"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Peter N Taylor, Vijay Panicker, Adrian Sayers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Endocrinol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/EJE-10-0938"}], "href": "https://doi.org/10.1530/EJE-10-0938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21317282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21317282"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Michaela Granfors, Helena Karypidis, Frida Hosseini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphodiesterase 8B gene polymorphism in women with recurrent miscarriage: a retrospective case control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-13-121"}], "href": "https://doi.org/10.1186/1471-2350-13-121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23237535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23237535"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Anna Grandone, Laura Perrone, Grazia Cirillo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of phosphodiesterase 8B gene rs4704397 variation on thyroid homeostasis in childhood obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Endocrinol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/EJE-11-0703"}], "href": "https://doi.org/10.1530/EJE-11-0703"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22084153"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22084153"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rolf Jorde, Henrik Schirmer, Tom Wilsgaard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The phosphodiesterase 8B gene rs4704397 is associated with thyroid function, risk of myocardial infarction, and body height: the Tromsø study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thyroid (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/thy.2013.0177"}], "href": "https://doi.org/10.1089/thy.2013.0177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23941514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23941514"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Anelia Horvath, Christoforos Giatzakis, Kitman Tsang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2008.85"}], "href": "https://doi.org/10.1038/ejhg.2008.85"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18431404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18431404"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Anelia Horvath, Fabio Faucz, Gabriela P Finkielstain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Haplotype analysis of the promoter region of phosphodiesterase type 8B (PDE8B) in correlation with inactivating PDE8B mutation and the serum thyroid-stimulating hormone levels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thyroid (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/thy.2009.0260"}], "href": "https://doi.org/10.1089/thy.2009.0260"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20373981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20373981"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "S Pérez-Torres, R Cortés, M Tolnay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Neurol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-4886(03)00042-6"}], "href": "https://doi.org/10.1016/s0014-4886(03"}, {"type": "t", "text": "00042-6) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12895443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12895443"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jie Ni, Xiaoping Yi, Zhen Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical findings of autosomal-dominant striatal degeneration and PDE8B mutation screening in parkinsonism and related disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Parkinsonism Relat Disord (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.parkreldis.2019.11.002"}], "href": "https://doi.org/10.1016/j.parkreldis.2019.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31726290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31726290"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Reo Azuma, Kinya Ishikawa, Kosei Hirata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel mutation of PDE8B Gene in a Japanese family with autosomal-dominant striatal degeneration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mov Disord (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mds.26345"}], "href": "https://doi.org/10.1002/mds.26345"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26769607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26769607"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Tian-Sin Fan, Ruey-Meei Wu, Han-I Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDE8B mutation is not associated with Parkinson's disease in a Taiwanese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2018.05.024"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2018.05.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29909144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29909144"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Masaaki Hayashi, Yasuhito Shimada, Yuhei Nishimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-291x(02)02371-9"}], "href": "https://doi.org/10.1016/s0006-291x(02"}, {"type": "t", "text": "02371-9) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12372422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12372422"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Federica Campolo, Chiara Capponi, Maria Grazia Tarsitano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "cAMP-specific phosphodiesterase 8A and 8B isoforms are differentially expressed in human testis and Leydig cell tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Endocrinol (Lausanne) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fendo.2022.1010924"}], "href": "https://doi.org/10.3389/fendo.2022.1010924"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36277728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36277728"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ming Zhan, Shuang-xia Zhao, Zhao-hui Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Association analysis of PDE8B gene polymorphisms with the susceptibility to Hyperthyroxinemia in Chinese Han population]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Za Zhi (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22781450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22781450"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Shuai Yang, Jun Tao, Junyu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic association study of phosphodiesterase 8B gene with subclinical hypothyroidism in pregnant women."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/07435800.2015.1015728"}], "href": "https://doi.org/10.3109/07435800.2015.1015728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25822812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25822812"}]}]}]}
Synonyms	ADSD, PPNAD3
Proteins	PDE8B_HUMAN
NCBI Gene ID	8622
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PDE8B has 6,390 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 125 datasets.

Click the + buttons to view associations for PDE8B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PDE8B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE8B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE8B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PDE8B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PDE8B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PDE8B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDE8B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PDE8B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDE8B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDE8B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDE8B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PDE8B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PDE8B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDE8B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PDE8B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PDE8B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with PDE8B gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with PDE8B gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PDE8B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PDE8B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PDE8B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PDE8B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PDE8B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PDE8B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PDE8B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDE8B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PDE8B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PDE8B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PDE8B gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PDE8B gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PDE8B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving PDE8B gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving PDE8B gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PDE8B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PDE8B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PDE8B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PDE8B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PDE8B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PDE8B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PDE8B protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PDE8B gene from the ENCODE Histone Modification Site Profiles dataset.