PDHA1 Gene

Name pyruvate dehydrogenase (lipoamide) alpha 1
Description The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPDHA1, the E1α catalytic subunit of the pyruvate dehydrogenase complex, serves as a critical metabolic “gatekeeper” by converting pyruvate into acetyl‐CoA—a reaction that bridges glycolysis with the tricarboxylic acid cycle. Its activity is subject to dynamic control by reversible phosphorylation (both serine‐ and tyrosine‐directed modifications), which regulates substrate access and flux through mitochondrial oxidation. In addition, external signals such as extracellular matrix attachment, growth factors, and insulin further modulate PDHA1 function, thereby adapting energetic output to cellular demands."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAltered PDHA1 function—through genetic mutations or dysregulated expression—has been implicated in a broad spectrum of diseases. Inherited PDHA1 mutations underlie pyruvate dehydrogenase complex deficiencies, manifesting as neonatal lactic acidosis, diverse neurodevelopmental abnormalities, characteristic neuroimaging patterns, and episodic metabolic decompensation. Somatic defects in PDHA1 are also increasingly recognized in various human cancers including prostate, gastric, colorectal, hepatocellular, and head and neck carcinomas, where reduced PDHA1 activity shifts metabolism toward aerobic glycolysis (the Warburg effect), promotes lipid biosynthesis and tumor growth, and is associated with poor clinical outcomes. Structural analyses of PDHA1 mutants have further illuminated the molecular basis for enzymatic inactivation observed in these pathological settings."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "24"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in energy metabolism and oncogenesis, emerging studies indicate that PDHA1 participates in broader regulatory networks influencing immune responses and cellular homeostasis. Autoimmune reactivity to PDHA1 epitopes has been documented in certain patients, implicating it in immune‐mediated disease processes, while its post‐translational modification and subcellular redistribution (including nuclear translocation) have been associated with alterations in histone acetylation, tumor cell stemness, and resistance to cytotoxic insults. Moreover, experimental models demonstrate that deliberate modulation of PDHA1 function—whether by genetic ablation or pharmacological interventions—can reprogram tumor metabolism and attenuate inflammatory or ischemic injury in conditions such as sepsis‐induced kidney injury and diabetic nephropathy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "25", "end_ref": "32"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yasuaki Hiromasa, Tetsuro Fujisawa, Yoichi Aso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M308172200"}], "href": "https://doi.org/10.1074/jbc.M308172200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14638692"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14638692"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Henriette Pilegaard, Jesper B Birk, Massimo Sacchetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db06-0152"}], "href": "https://doi.org/10.2337/db06-0152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17065338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17065338"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kristian Kiilerich, Jesper B Birk, Rasmus Damsgaard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of PDH in human arm and leg muscles at rest and during intense exercise."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Endocrinol Metab (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpendo.00352.2007"}], "href": "https://doi.org/10.1152/ajpendo.00352.2007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17957032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17957032"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alexandra R Grassian, Christian M Metallo, Jonathan L Coloff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.16771811"}], "href": "https://doi.org/10.1101/gad.16771811"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21852536"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21852536"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jun Fan, Hee-Bum Kang, Changliang Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.593970"}], "href": "https://doi.org/10.1074/jbc.M114.593970"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25104357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25104357"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Rokibul Islam, Jae-Gyu Kim, Yohan Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin induces phosphorylation of pyruvate dehydrogenase through RhoA activation pathway in HepG2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201800917R"}], "href": "https://doi.org/10.1096/fj.201800917R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30226812"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30226812"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Marjolein Willemsen, Richard J T Rodenburg, Alexandra Teszas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Females with PDHA1 gene mutations: a diagnostic challenge."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mitochondrion (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mito.2006.03.001"}], "href": "https://doi.org/10.1016/j.mito.2006.03.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16713755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16713755"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "H M Strassburg, J Koch, J Mayr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acute flaccid paralysis as initial symptom in 4 patients with novel E1alpha mutations of the pyruvate dehydrogenase complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropediatrics (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/s-2006-924555"}], "href": "https://doi.org/10.1055/s-2006-924555"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16967364"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16967364"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Maria João Silva, Ana Pinheiro, Filomena Eusébio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyruvate dehydrogenase deficiency: identification of a novel mutation in the PDHA1 gene which responds to amino acid supplementation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pediatr (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00431-008-0700-7"}], "href": "https://doi.org/10.1007/s00431-008-0700-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18398624"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18398624"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Lyudmyla G Glushakova, Matthew J Lisankie, Evgeniy B Eruslanov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AAV3-mediated transfer and expression of the pyruvate dehydrogenase E1 alpha subunit gene causes metabolic remodeling and apoptosis of human liver cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2009.05.010"}], "href": "https://doi.org/10.1016/j.ymgme.2009.05.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19586787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19586787"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "E Quintana, L Gort, C Busquets, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutational study in the PDHA1 gene of 40 patients suspected of pyruvate dehydrogenase complex deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1399-0004.2009.01313.x"}], "href": "https://doi.org/10.1111/j.1399-0004.2009.01313.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20002461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20002461"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nicholas Ah Mew, Johanna B Loewenstein, Nadja Kadom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MRI features of 4 female patients with pyruvate dehydrogenase E1 alpha deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Neurol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pediatrneurol.2011.02.003"}], "href": "https://doi.org/10.1016/j.pediatrneurol.2011.02.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21723463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21723463"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ruchi Sharma, Mark J Sharrard, Daniel J Connolly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unilateral periventricular leukomalacia in association with pyruvate dehydrogenase deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Med Child Neurol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1469-8749.2011.04108.x"}], "href": "https://doi.org/10.1111/j.1469-8749.2011.04108.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21895644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21895644"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "A Imbard, A Boutron, C Vequaud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of 82 patients with pyruvate dehydrogenase complex deficiency. Structural implications of novel amino acid substitutions in E1 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2011.08.008"}], "href": "https://doi.org/10.1016/j.ymgme.2011.08.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21914562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21914562"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Gaia Giribaldi, Laura Doria-Lamba, Roberta Biancheri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intermittent-relapsing pyruvate dehydrogenase complex deficiency: a case with clinical, biochemical, and neuroradiological reversibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Med Child Neurol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1469-8749.2011.04151.x"}], "href": "https://doi.org/10.1111/j.1469-8749.2011.04151.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22142326"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22142326"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ana Pinheiro, Maria João Silva, Inês Graça, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyruvate dehydrogenase complex: mRNA and protein expression patterns of E1α subunit genes in human spermatogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2012.06.068"}], "href": "https://doi.org/10.1016/j.gene.2012.06.068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22750801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22750801"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Atsushi Hamabe, Hirofumi Yamamoto, Masamitsu Konno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined evaluation of hexokinase 2 and phosphorylated pyruvate dehydrogenase-E1α in invasive front lesions of colorectal tumors predicts cancer metabolism and patient prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.12487"}], "href": "https://doi.org/10.1111/cas.12487"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25060325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25060325"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Fabao Liu, Weiying Zhang, Xiaona You, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4508"}], "href": "https://doi.org/10.18632/oncotarget.4508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26309161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26309161"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Jingjing Chen, Ilaria Guccini, Diletta Di Mitri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41588-017-0026-3"}], "href": "https://doi.org/10.1038/s41588-017-0026-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29335542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29335542"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jihong Sun, Jingjing Li, Zhixian Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Pyruvate Dehydrogenase E1α Subunit Inhibits Warburg Effect and Induces Cell Apoptosis Through Mitochondria-Mediated Pathway in Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3727/096504018X15180451872087"}], "href": "https://doi.org/10.3727/096504018X15180451872087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29444744"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29444744"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": " Dan Li, Chaoqun Wang, Panfei Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0494-0"}], "href": "https://doi.org/10.1038/s41419-018-0494-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29700317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29700317"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Matthew J Whitley, Palaniappa Arjunan, Natalia S Nemeria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyruvate dehydrogenase complex deficiency is linked to regulatory loop disorder in the αV138M variant of human pyruvate dehydrogenase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.003996"}], "href": "https://doi.org/10.1074/jbc.RA118.003996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29970614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29970614"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Tsai-Ying Chen, Yi-Ta Hsieh, Jian-Min Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neo.2019.04.007"}], "href": "https://doi.org/10.1016/j.neo.2019.04.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31100640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31100640"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Kuntal Sen, George Grahame, Jirair K Bedoyan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel presentations associated with a PDHA1 variant - Alternating hemiplegia in Hemizygote proband and Guillain Barre Syndrome in Heterozygote mother."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Paediatr Neurol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejpn.2021.01.006"}], "href": "https://doi.org/10.1016/j.ejpn.2021.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33592356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33592356"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Tsutomu Mori, Kazuo Ono, Masatoshi Hakozaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epitope mapping on E1alpha subunit of pyruvate dehydrogenase complex with autoantibodies of patients with primary biliary cirrhosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Liver Int (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1034/j.1478-3231.2003.00857.x"}], "href": "https://doi.org/10.1034/j.1478-3231.2003.00857.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14708897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14708897"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "M Magner, K Vinšová, M Tesařová, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two patients with clinically distinct manifestation of pyruvate dehydrogenase deficiency due to mutations in PDHA1 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prague Med Rep (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21470495"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21470495"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Israa Sharkia, Tal Hadad Erlich, Nadine Landolina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyruvate dehydrogenase has a major role in mast cell function, and its activity is regulated by mitochondrial microphthalmia transcription factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Allergy Clin Immunol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jaci.2016.09.047"}], "href": "https://doi.org/10.1016/j.jaci.2016.09.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27871875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27871875"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Yali Zhong, Xiaoli Li, Yasai Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyruvate dehydrogenase expression is negatively associated with cell stemness and worse clinical outcome in prostate cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.14527"}], "href": "https://doi.org/10.18632/oncotarget.14527"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28076853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28076853"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Wei-Ye Shi, Xiao Yang, Bo Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NOK mediates glycolysis and nuclear PDC associated histone acetylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Biosci (Landmark Ed) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2741/4572"}], "href": "https://doi.org/10.2741/4572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28410146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28410146"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Yajuan Zhang, Ming Zhao, Hong Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Metab (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42255-022-00543-7"}], "href": "https://doi.org/10.1038/s42255-022-00543-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35315437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35315437"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Chung-Hsing Wang, Wen-Li Lu, Shang-Lun Chiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "T Cells Mediate Kidney Tubular Injury via Impaired PDHA1 and Autophagy in Type 1 Diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/clinem/dgac378"}], "href": "https://doi.org/10.1210/clinem/dgac378"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35731579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35731579"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Sheng An, Yi Yao, Hongbin Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-05952-4"}], "href": "https://doi.org/10.1038/s41419-023-05952-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37479690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37479690"}]}]}]}
Synonyms PDHCE1A, PDHAD, PDHA, PHE1A
Proteins ODPA_HUMAN
NCBI Gene ID 5160
API
Download Associations
Predicted Functions View PDHA1's ARCHS4 Predicted Functions.
Co-expressed Genes View PDHA1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View PDHA1's ARCHS4 Predicted Functions.

Functional Associations

PDHA1 has 7,935 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 129 datasets.

Click the + buttons to view associations for PDHA1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Achilles Cell Line Gene Essentiality Profiles cell lines with fitness changed by PDHA1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of PDHA1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of PDHA1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of PDHA1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of PDHA1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of PDHA1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of PDHA1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PDHA1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PDHA1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of PDHA1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of PDHA1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with PDHA1 protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with PDHA1 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDHA1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of PDHA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of PDHA1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
ClinVar Gene-Phenotype Associations phenotypes associated with PDHA1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PDHA1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing PDHA1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing PDHA1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with PDHA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with PDHA1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of PDHA1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with PDHA1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with PDHA1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with PDHA1 gene/protein from the curated CTD Gene-Disease Associations dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by PDHA1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DEPOD Substrates of Phosphatases phosphatases that dephosphorylate PDHA1 protein from the curated DEPOD Substrates of Phosphatases dataset.
DISEASES Curated Gene-Disease Association Evidence Scores diseases involving PDHA1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
DISEASES Curated Gene-Disease Association Evidence Scores 2025 diseases involving PDHA1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with PDHA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with PDHA1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with PDHA1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with PDHA1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
DrugBank Drug Targets interacting drugs for PDHA1 protein from the curated DrugBank Drug Targets dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at PDHA1 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDHA1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of PDHA1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing PDHA1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of PDHA1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with PDHA1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing PDHA1 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of PDHA1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of PDHA1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of PDHA1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PDHA1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of PDHA1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of PDHA1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving PDHA1 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving PDHA1 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving PDHA1 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing PDHA1 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing PDHA1 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing PDHA1 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by PDHA1 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by PDHA1 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by PDHA1 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of PDHA1 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of PDHA1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of PDHA1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of PDHA1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of PDHA1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of PDHA1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HMDB Metabolites of Enzymes interacting metabolites for PDHA1 protein from the curated HMDB Metabolites of Enzymes dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of PDHA1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of PDHA1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of PDHA1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of PDHA1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
HPO Gene-Disease Associations phenotypes associated with PDHA1 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for PDHA1 from the curated Hub Proteins Protein-Protein Interactions dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with PDHA1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for PDHA1 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of PDHA1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEA Substrates of Kinases kinases that phosphorylate PDHA1 protein from the curated KEA Substrates of Kinases dataset.
KEGG Pathways pathways involving PDHA1 protein from the KEGG Pathways dataset.
Kinase Library Serine Threonine Kinome Atlas kinases that phosphorylate PDHA1 protein from the Kinase Library Serine Threonine Atlas dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of PDHA1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of PDHA1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with PDHA1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of PDHA1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of PDHA1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of PDHA1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of PDHA1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Curated Protein Localization Annotations cellular components containing PDHA1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain PDHA1 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by PDHA1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets microRNAs targeting PDHA1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of PDHA1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MoTrPAC Rat Endurance Exercise Training tissue samples with high or low expression of PDHA1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by PDHA1 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations gene perturbations changing expression of PDHA1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
MW Enzyme Metabolite Associations interacting metabolites for PDHA1 protein from the MW Gene Metabolite Associations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of PDHA1 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
NURSA Protein Complexes protein complexs containing PDHA1 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
NURSA Protein-Protein Interactions interacting proteins for PDHA1 from the NURSA Protein-Protein Interactions dataset.
OMIM Gene-Disease Associations phenotypes associated with PDHA1 gene from the curated OMIM Gene-Disease Associations dataset.
PANTHER Pathways pathways involving PDHA1 protein from the PANTHER Pathways dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for PDHA1 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of PDHA1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of PDHA1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving PDHA1 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving PDHA1 protein from the Wikipathways PFOCR 2024 dataset.
Phosphosite Textmining Biological Term Annotations biological terms co-occuring with PDHA1 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
PhosphoSitePlus Substrates of Kinases kinases that phosphorylate PDHA1 protein from the curated PhosphoSitePlus Substrates of Kinases dataset.
ProteomicsDB Cell Type and Tissue Protein Expression Profiles cell types and tissues with high or low expression of PDHA1 protein relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset.
Reactome Pathways 2014 pathways involving PDHA1 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving PDHA1 protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of PDHA1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of PDHA1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of PDHA1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of PDHA1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at PDHA1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of PDHA1 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of PDHA1 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with PDHA1 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs drug perturbations changing phosphorylation of PDHA1 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset.
Tabula Sapiens Gene-Cell Associations cell types with high or low expression of PDHA1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of PDHA1 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of PDHA1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of PDHA1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of PDHA1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of PDHA1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of PDHA1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of PDHA1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of PDHA1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with PDHA1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with PDHA1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving PDHA1 protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving PDHA1 protein from the WikiPathways Pathways 2024 dataset.