PDK2 Gene

Name	pyruvate dehydrogenase kinase, isozyme 2
Description	This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPyruvate dehydrogenase kinase 2 (PDK2) is a central metabolic regulator that phosphorylates and thereby inactivates the pyruvate dehydrogenase complex (PDH), controlling the conversion of pyruvate to acetyl‐CoA. In cancer cells, wild‐type p53 downregulates PDK2 expression to reduce PDH inactivation and limit the glycolytic, lactate‐producing Warburg effect, whereas elevated PDK2 promotes this metabolic shift. Similarly, pharmacologic inhibition using dichloroacetate (DCA) targets PDK2 to reactivate glucose oxidation and attenuate hypoxia‐inducible factor 1α (HIF1α) signaling, underscoring its importance in metabolic reprogramming. Moreover, microRNA-mediated repression of PDK2 restores PDH activity and shifts metabolism toward oxidative phosphorylation while impacting lipogenesis and cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural and transcriptional studies have provided detailed insights into PDK2 regulation. High‐resolution crystallographic analyses have revealed multiple novel ligand binding sites on PDK2 that govern conformational changes in its active site, influencing its catalytic efficiency and responsiveness to inhibitors. In parallel, nuclear receptors such as PPARβ/δ directly regulate the expression of PDK2, thereby integrating signals related to nutrient availability and energy status. In human skeletal muscle, hormonal and nutritional cues modulate PDK2 transcript abundance, while structure‐guided inhibitors like PS10 specifically target PDK2 to enhance PDH complex function and improve metabolic homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, aberrant PDK2 activity contributes significantly to chemoresistance and tumor progression. Elevated PDK2 expression has been observed in cisplatin‐resistant head and neck cancers as well as lung adenocarcinomas, where it drives tumor growth through downstream signaling pathways. Additionally, high PDK2 levels serve as an adverse prognostic marker in acute myeloid leukemia, linking its dysregulation to poor clinical outcomes. Beyond its metabolic enzyme role, PDK2 also phosphorylates the mitochondrial rhomboid protease PARL, modulating its cleavage and thereby connecting mitochondrial metabolism to the regulation of mitophagy and overall mitochondrial quality control."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBiochemical and kinetic studies have elucidated the complex molecular mechanisms governing PDK2 activity. Detailed analyses show that PDK2 catalysis is heavily influenced by ionic factors; binding of K⁺ and inorganic phosphate (Pi) to sites distinct from the active site modulates ligand affinity and catalytic turnover. Reversible oxidation of specific cysteine residues by low levels of hydrogen peroxide further fine‐tunes PDK2 activity by increasing PDH complex activity, while interactions with the lipoyl domain of the dihydrolipoyl acetyltransferase core (E2) are critical for its full activation. Such studies, which include rigorous kinetic characterization and structural analyses, highlight the sophisticated regulation of PDK2 via both its microenvironment and post‐translational modifications."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tanupriya Contractor, Chris R Harris "}, {"type": "b", "children": [{"type": "t", "text": "p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-11-1215"}], "href": "https://doi.org/10.1158/0008-5472.CAN-11-1215"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22123926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22123926"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "G Sutendra, P Dromparis, A Kinnaird, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.198"}], "href": "https://doi.org/10.1038/onc.2012.198"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22614004"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22614004"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhongyuan He, Zheng Li, Xuan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0564-3"}], "href": "https://doi.org/10.1038/s41419-018-0564-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29725130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29725130"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Thomas R Hurd, Yvonne Collins, Irina Abakumova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.400002"}], "href": "https://doi.org/10.1074/jbc.M112.400002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22910903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22910903"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Thorsten R Knoechel, Alec D Tucker, Colin M Robinson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi051402s"}], "href": "https://doi.org/10.1021/bi051402s"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16401071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16401071"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tatjana Degenhardt, Anna Saramäki, Marjo Malinen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2007.06.091"}], "href": "https://doi.org/10.1016/j.jmb.2007.06.091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17669420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17669420"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Emily L Abbot, James G McCormack, Christine Reynet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1742-4658.2005.04713.x"}], "href": "https://doi.org/10.1111/j.1742-4658.2005.04713.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15955060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15955060"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shih-Chia Tso, Xiangbing Qi, Wen-Jun Gui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure-guided development of specific pyruvate dehydrogenase kinase inhibitors targeting the ATP-binding pocket."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.533885"}], "href": "https://doi.org/10.1074/jbc.M113.533885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24356970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24356970"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jong-Lyel Roh, Jin Young Park, Eun Hye Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of mitochondrial oxidation by PDK2 inhibition reverses cisplatin resistance in head and neck cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2015.11.023"}], "href": "https://doi.org/10.1016/j.canlet.2015.11.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26607904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26607904"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Guang Shi, G Angus McQuibban "}, {"type": "b", "children": [{"type": "t", "text": "The Mitochondrial Rhomboid Protease PARL Is Regulated by PDK2 to Integrate Mitochondrial Quality Control and Metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2017.01.029"}], "href": "https://doi.org/10.1016/j.celrep.2017.01.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28178523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28178523"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hongying Gang, Rimpy Dhingra, Junjun Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201504047"}], "href": "https://doi.org/10.1083/jcb.201504047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26416963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26416963"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Longzhen Cui, Zhiheng Cheng, Yan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of PDK2 and PDK3 reflects poor prognosis in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41417-018-0071-9"}], "href": "https://doi.org/10.1038/s41417-018-0071-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30578412"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30578412"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tinghua Hu, Shuo Yu, Yang Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDK2 induces cisplatin-resistance in lung adenocarcinoma via transcriptional regulation of CNNM3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Drug Target (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/1061186X.2018.1550648"}], "href": "https://doi.org/10.1080/1061186X.2018.1550648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30457021"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30457021"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Matthew J Watt, George J F Heigenhauser, Paul J LeBlanc, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rapid upregulation of pyruvate dehydrogenase kinase activity in human skeletal muscle during prolonged exercise."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Appl Physiol (1985) (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/japplphysiol.00132.2004"}], "href": "https://doi.org/10.1152/japplphysiol.00132.2004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15169745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15169745"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yasuaki Hiromasa, Xiaohua Yan, Thomas E Roche "}, {"type": "b", "children": [{"type": "t", "text": "Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi7014772"}], "href": "https://doi.org/10.1021/bi7014772"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18220415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18220415"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yasuaki Hiromasa, Thomas E Roche "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi701475f"}], "href": "https://doi.org/10.1021/bi701475f"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18220414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18220414"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Y C Ren, T B Jin, X D Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDK2 and ABCG2 genes polymorphisms are correlated with blood glucose levels and uric acid in Tibetan gout patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/gmr.15017447"}], "href": "https://doi.org/10.4238/gmr.15017447"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26909964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26909964"}]}]}]}
Synonyms	PDKII, PDHK2
Proteins	PDK2_HUMAN
NCBI Gene ID	5164
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PDK2 has 6,993 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for PDK2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PDK2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PDK2 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDK2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PDK2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PDK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PDK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDK2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving PDK2 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PDK2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDK2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDK2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PDK2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDK2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PDK2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with PDK2 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PDK2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PDK2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDK2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PDK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PDK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PDK2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PDK2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PDK2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PDK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PDK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PDK2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PDK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PDK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDK2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PDK2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PDK2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PDK2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PDK2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PDK2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for PDK2 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PDK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PDK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PDK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PDK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for PDK2 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PDK2 gene from the ENCODE Histone Modification Site Profiles dataset.