PDLIM5 Gene

Name	PDZ and LIM domain 5
Description	This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPDLIM5 is an adaptor protein that contains a PDZ domain along with several LIM domains, and it plays a critical role in neuronal signaling and the regulation of calcium dynamics. In the central nervous system, PDLIM5 modulates neuronal calcium signaling by interacting with protein kinase C isoforms—especially PKCε—and the N‐type calcium channel, a function that appears to have important implications for the pathophysiology of mood disorders such as bipolar disorder, major depression, and schizophrenia. Altered expression of PDLIM5 has been observed both in postmortem brain tissues and in peripheral cells (e.g. lymphoblastoid cells or leukocytes) of affected patients, and treatment with agents such as paroxetine appears to normalize its reduced levels in depressive states. In addition, several genetic association studies have evaluated variants in the PDLIM5 gene in different ethnic cohorts, highlighting its potential contribution as a susceptibility factor for these psychiatric conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in neuronal function, PDLIM5 is integral to the regulation of cytoskeletal dynamics and mechanotransduction. It links extracellular mechanical signals to intracellular responses by associating with actin‐binding proteins such as α‑actinin, thereby facilitating the proper localization and activation of key transcriptional regulators—for example, supporting the nuclear localization and activity of YAP in response to force transmitted via integrin adhesions. This mechanosensitive function extends to the regulation of cell differentiation processes including cardiomyogenesis, where specific stage‐dependent isoforms of PDLIM5 emerge concurrently with early cardiac transcription factors, and osteogenic differentiation, in which PDLIM5 helps mediate microfilament assembly to promote a mature osteoblast phenotype. Moreover, its role in maintaining the integrity of contractile structures has ramifications in tissues such as cardiac and kidney muscle."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPDLIM5 also appears to contribute to cancer progression and risk. Its regulatory influence on cell migration and invasion has been documented in various tumor types. In papillary thyroid carcinoma cells, for instance, knockdown of PDLIM5 impairs Ras-ERK signaling and reduces malignant behaviors, while in non-small cell lung cancer its interaction with SMAD3 stabilizes the transcription factor and promotes TGFβ-induced epithelial–mesenchymal transition—a key step in metastasis. Moreover, several genome-wide association and candidate gene studies in prostate cancer have investigated single nucleotide polymorphisms in or near PDLIM5, and emerging evidence supports that genetic variants in this gene may be linked to cancer risk and potentially interact with steroid-related pathways. Together, these findings suggest that PDLIM5’s capacity to modulate cytoskeletal reorganization and signaling cascades is a common thread uniting its roles in oncogenesis with its other biological functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "K Iwamoto, C Kakiuchi, M Bundo, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Positive association between the PDLIM5 gene and bipolar disorder in the Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Psychiatry Neurosci (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19448850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19448850"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mohd Aizat Zain, Suffee Nusrat Jahan, Gavin P Reynolds, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Peripheral PDLIM5 expression in bipolar disorder and the effect of olanzapine administration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2350-13-91"}], "href": "https://doi.org/10.1186/1471-2350-13-91"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23031404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23031404"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mohd A Zain, Siti N Roffeei, Nor Z Zainal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nonsynonymous polymorphisms of the PDLIM5 gene association with the occurrence of both bipolar disorder and schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Psychiatr Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/YPG.0000000000000015"}], "href": "https://doi.org/10.1097/YPG.0000000000000015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24064681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24064681"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ya Su, Thomas F Hiemstra, Yahui Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDLIM5 links kidney anion exchanger 1 (kAE1) to ILK and is required for membrane targeting of kAE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep39701"}], "href": "https://doi.org/10.1038/srep39701"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28045035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28045035"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Sarah A Konze, Sebastian Werneburg, Astrid Oberbeck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.6b00534"}], "href": "https://doi.org/10.1021/acs.jproteome.6b00534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28139119"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28139119"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ahmed Elbediwy, Hannah Vanyai, Maria-Del-Carmen Diaz-de-la-Loza, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Novel polymorphisms in PDLIM3 and PDLIM5 gene encoding Z-line proteins increase risk of idiopathic dilated cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14607"}], "href": "https://doi.org/10.1111/jcmm.14607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31424159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31424159"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xiaolan Huang, Rongmei Qu, Yan Peng, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "[Association of prostate cancer with PDLIM5, SLC22A3 and NKX3-1 in Chinese men]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Nan Ke Xue (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22741436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22741436"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Ke-Sheng Wang, Daniel Owusu, Yue Pan, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in PDLIM5 gene are associated with alcohol dependence, type 2 diabetes, and hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Psychiatr Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jpsychires.2016.09.015"}], "href": "https://doi.org/10.1016/j.jpsychires.2016.09.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27693979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27693979"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xiaodan Wei, Yuan Zhang, Shoujun Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDLIM5 identified by label-free quantitative proteomics as a potential novel biomarker of papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.03.159"}], "href": "https://doi.org/10.1016/j.bbrc.2018.03.159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29574154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29574154"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Yueli Shi, Xinyu Wang, Zhiyong Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDLIM5 inhibits STUB1-mediated degradation of SMAD3 and promotes the migration and invasion of lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.014976"}], "href": "https://doi.org/10.1074/jbc.RA120.014976"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32737199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32737199"}]}]}]}
Synonyms	ENH1, ENH, LIM
Proteins	PDLI5_HUMAN
NCBI Gene ID	10611
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PDLIM5 has 16,143 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 139 datasets.

Click the + buttons to view associations for PDLIM5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PDLIM5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by PDLIM5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDLIM5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDLIM5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PDLIM5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PDLIM5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PDLIM5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDLIM5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PDLIM5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDLIM5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDLIM5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PDLIM5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDLIM5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PDLIM5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PDLIM5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PDLIM5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDLIM5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PDLIM5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PDLIM5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PDLIM5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PDLIM5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PDLIM5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PDLIM5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PDLIM5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PDLIM5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PDLIM5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PDLIM5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PDLIM5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PDLIM5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PDLIM5 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PDLIM5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PDLIM5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PDLIM5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PDLIM5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PDLIM5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PDLIM5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PDLIM5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PDLIM5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PDLIM5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDLIM5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PDLIM5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.