PDLIM7 Gene

Name	PDZ and LIM domain 7 (enigma)
Description	The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPDLIM7, also known as Enigma, is a PDZ and LIM domain‐containing adapter protein that plays a critical role in cellular mechanotransduction. It is recruited from the cytoplasm to integrin adhesion sites and F‐actin stress fibers by binding directly to α‐actinin, thereby facilitating the force‐dependent nuclear localization and activation of the transcriptional co‐activator YAP. Such signaling is essential for translating mechanical cues into gene expression programs."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in mechanosensation, PDLIM7 modulates key signaling pathways by interacting with regulatory proteins. It directly associates with MDM2, inhibiting MDM2 self‐ubiquitination and enhancing its ubiquitin ligase activity toward p53. This activity contributes to p53 degradation and promotes cell survival and chemoresistance. Furthermore, in the context of CDK4/6 inhibitor‐treated cells, PDLIM7 helps regulate MDM2 levels—a process that appears critical for the transition of tumor cells from quiescence to senescence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn metabolic regulation, overexpression of PDLIM7 has been shown to interfere with actin cytoskeleton rearrangements that are necessary for insulin‐stimulated glucose transporter (GLUT4) translocation. This results in a reduction of glucose uptake in adipocytes, highlighting a role for PDLIM7 in modulating insulin responsiveness via its effects on cortical actin dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nPDLIM7 also exerts influence over receptor tyrosine kinase signaling. By interacting with the E3 ubiquitin ligase Cbl‐c, it blocks the ubiquitination and subsequent degradation of activated RET (including oncogenic isoforms such as RETMEN2A). This stabilization of the receptor promotes sustained ERK activation, identifying PDLIM7 as a positive regulator of RET signaling in certain cellular contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, dysregulation of PDLIM7 expression is associated with cancer progression. In thyroid cancers, for example, elevated levels of PDLIM7 correlate with advanced stages and aggressive clinical behavior. In papillary thyroid carcinoma, PDLIM7 contributes to metastasis by promoting focal adhesion assembly and by preventing proteasome‐dependent degradation of focal adhesion kinase (FAK), a key mediator of cell migration and invasion. Interactions with additional proteins such as AKT, VDR, BMP‐1, and MDM2 underscore its multifaceted role in tumorigenesis and its potential utility as a prognostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ahmed Elbediwy, Hannah Vanyai, Maria-Del-Carmen Diaz-de-la-Loza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enigma proteins regulate YAP mechanotransduction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.221788"}], "href": "https://doi.org/10.1242/jcs.221788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30404826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30404826"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cho-Rok Jung, Jung Hwa Lim, Yoonjung Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enigma negatively regulates p53 through MDM2 and promotes tumor cell survival in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI42674"}], "href": "https://doi.org/10.1172/JCI42674"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21060154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21060154"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mary E Klein, Mark A Dickson, Cristina Antonescu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDLIM7 and CDH18 regulate the turnover of MDM2 during CDK4/6 inhibitor therapy-induced senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0332-y"}], "href": "https://doi.org/10.1038/s41388-018-0332-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29789718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29789718"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Romain Barrès, Thierry Grémeaux, Philippe Gual, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2005-0455"}], "href": "https://doi.org/10.1210/me.2005-0455"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16803868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16803868"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Stephen C Kales, Marion M Nau, Anand S Merchant, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enigma prevents Cbl-c-mediated ubiquitination and degradation of RETMEN2A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0087116"}], "href": "https://doi.org/10.1371/journal.pone.0087116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24466333"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24466333"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kristiana Rood, Celina Romi Yamauchi, Umang Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulatory and Interacting Partners of PDLIM7 in Thyroid Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/curroncol30120761"}], "href": "https://doi.org/10.3390/curroncol30120761"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38132395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38132395"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fan Yang, Mingqing Yang, Yi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDLIM7 Promotes Tumor Metastasis in Papillary Thyroid Carcinoma via Stabilizing Focal Adhesion Kinase Protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thyroid (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/thy.2023.0497"}], "href": "https://doi.org/10.1089/thy.2023.0497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38243825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38243825"}]}]}]}
Synonyms	LMP3, LMP1
Proteins	PDLI7_HUMAN
NCBI Gene ID	9260
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PDLIM7 has 9,305 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 125 datasets.

Click the + buttons to view associations for PDLIM7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PDLIM7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDLIM7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDLIM7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PDLIM7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PDLIM7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDLIM7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PDLIM7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDLIM7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDLIM7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PDLIM7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDLIM7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PDLIM7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PDLIM7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PDLIM7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDLIM7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PDLIM7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PDLIM7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PDLIM7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PDLIM7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PDLIM7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PDLIM7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PDLIM7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PDLIM7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PDLIM7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDLIM7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PDLIM7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PDLIM7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PDLIM7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of PDLIM7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PDLIM7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PDLIM7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PDLIM7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PDLIM7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PDLIM7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PDLIM7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PDLIM7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDLIM7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PDLIM7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PDLIM7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PDLIM7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PDLIM7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.