PDS5A Gene

Name	PDS5 cohesin associated factor A
Description	The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPDS5A is a multifaceted regulator of cohesin function that plays a central role in organizing chromatin architecture. By interacting with the cohesin complex, PDS5A is required for establishing proper loop boundaries and controlling the length of chromatin loops, a process that appears to involve the pausing of loop extrusion at CTCF sites. In parallel, PDS5A selectively partners with the acetyltransferase Esco1 to promote the acetylation of the SMC3 subunit, thereby stabilizing cohesin’s association with chromatin and ensuring accurate sister chromatid cohesion."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its architectural functions, PDS5A is critical for maintaining proper DNA replication dynamics. It modulates the residence time of cohesin on chromatin, thereby facilitating replication fork progression. Loss or depletion of PDS5A leads to increased cohesin retention that can hinder the advance of the replisome, resulting in slowed fork progression. Moreover, PDS5A is essential for recruiting key replication fork protection factors such as WRNIP1, RAD51, and BRCA2, with its absence rendering forks vulnerable to MRE11-mediated degradation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAltered expression of PDS5A has been implicated in tumorigenesis. In glioblastoma, for instance, overexpression of PDS5A correlates with higher tumor grade, suggesting a role in the progression of astrocytic tumors. Similarly, studies in breast cancer models indicate that modulation of PDS5A levels can influence cellular proliferation, invasion, and migration. These findings underscore the importance of PDS5A not only in fundamental processes of chromatin cohesion and replication but also in the maintenance of genomic stability, with its dysregulation potentially contributing to cancer development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Masashi Minamino, Mai Ishibashi, Ryuichiro Nakato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Esco1 Acetylates Cohesin via a Mechanism Different from That of Esco2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2015.05.017"}], "href": "https://doi.org/10.1016/j.cub.2015.05.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26051894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26051894"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gordana Wutz, Csilla Várnai, Kota Nagasaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201798004"}], "href": "https://doi.org/10.15252/embj.201798004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29217591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29217591"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marjon S van Ruiten, Démi van Gent, Ángela Sedeño Cacciatore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41594-022-00773-z"}], "href": "https://doi.org/10.1038/s41594-022-00773-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35710836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35710836"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nenggang Zhang, Luiza E Coutinho, Debananda Pati "}, {"type": "b", "children": [{"type": "t", "text": "PDS5A and PDS5B in Cohesin Function and Human Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22115868"}], "href": "https://doi.org/10.3390/ijms22115868"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34070827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34070827"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Denisse Carvajal-Maldonado, Andrea K Byrum, Jessica Jackson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gky519"}], "href": "https://doi.org/10.1093/nar/gky519"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29917110"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29917110"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Carmen Morales, Miguel Ruiz-Torres, Sara Rodríguez-Acebes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.011099"}], "href": "https://doi.org/10.1074/jbc.RA119.011099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31757807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31757807"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Carsten Hagemann, Bettina Weigelin, Stephan Schommer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cohesin-interacting protein, precocious dissociation of sisters 5A/sister chromatid cohesion protein 112, is up-regulated in human astrocytic tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijmm.2010.551"}], "href": "https://doi.org/10.3892/ijmm.2010.551"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21069257"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21069257"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yang Wang, Jian Yao, Yulin Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of CDCA5 suppresses malignant progression of breast cancer cells by regulating PDS5A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2022.12725"}], "href": "https://doi.org/10.3892/mmr.2022.12725"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35506437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35506437"}]}]}]}
Synonyms	SCC-112, SCC112, PIG54
Proteins	PDS5A_HUMAN
NCBI Gene ID	23244
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PDS5A has 8,844 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 124 datasets.

Click the + buttons to view associations for PDS5A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PDS5A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDS5A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDS5A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PDS5A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of PDS5A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PDS5A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PDS5A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PDS5A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDS5A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PDS5A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PDS5A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDS5A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PDS5A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PDS5A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with PDS5A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDS5A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PDS5A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PDS5A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing PDS5A protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PDS5A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PDS5A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PDS5A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PDS5A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PDS5A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PDS5A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PDS5A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing PDS5A protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of PDS5A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PDS5A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PDS5A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PDS5A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with PDS5A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by PDS5A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with PDS5A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PDS5A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PDS5A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PDS5A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PDS5A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PDS5A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PDS5A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PDS5A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.