PELO Gene

Name	pelota homolog (Drosophila)
Description	This gene encodes a protein which contains a conserved nuclear localization signal. The encoded protein may have a role in spermatogenesis, cell cycle control, and in meiotic cell division. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPelota (PELO) is an evolutionarily conserved ribosome rescue factor that plays a central role in messenger RNA quality control. It functions in the No-Go Decay (NGD) and Non-Stop Decay (NSD) pathways by collaborating with partners such as Hbs1 and ABCE1 to promote the dissociation of stalled elongation complexes and release peptidyl-tRNA. In mammalian cells—where its yeast orthologue is known as Dom34—PELO is essential for recognizing aberrant mRNAs and facilitating their degradation, thereby ensuring translational fidelity and maintaining cellular homeostasis. Its activity minimizes inappropriate endonucleolytic cleavages associated with stalled ribosomes and contributes to proper cell proliferation and stem cell self-renewal."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn specialized cell types such as anucleate platelets and differentiating reticulocytes, PELO is upregulated to support ongoing protein synthesis when ribosome recycling factors like ABCE1 decline during terminal differentiation. In these blood lineages, the compensatory induction of PELO (together with HBS1L) is crucial to overcome the accumulation of post-termination, unrecycled ribosomes, thereby facilitating efficient translation of inherited mRNAs. Moreover, studies of megakaryocytic differentiation have demonstrated that while associated integrin genes undergo epigenetic changes, the PELO gene remains unaffected, underscoring its sustained importance in maintaining ribosome homeostasis during development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its classic translational surveillance role, PELO has emerged as a multifunctional regulator influencing both oncogenic signalling and innate immunity. It directly interacts with activated receptor tyrosine kinases such as HER2 and EGFR, attenuating the PI3K/AKT pathway and thereby reducing cell migration and metastasis. In parallel, PELO acts as a catalyzer for the assembly of NOD-like receptor inflammasomes by binding to multiple cytosolic NLRs and activating their ATPase activity, a step critical for the ordered oligomerization of these immune complexes and the initiation of effective host defense responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ozanna Burnicka-Turek, Aleksandra Kata, Byambajav Buyandelger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2121-11-28"}], "href": "https://doi.org/10.1186/1471-2121-11-28"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20406461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20406461"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Vera P Pisareva, Maxim A Skabkin, Christopher U T Hellen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.93"}], "href": "https://doi.org/10.1038/emboj.2011.93"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21448132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21448132"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Syuhei Saito, Nao Hosoda, Shin-ichi Hoshino "}, {"type": "b", "children": [{"type": "t", "text": "The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.448977"}], "href": "https://doi.org/10.1074/jbc.M112.448977"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23667253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23667253"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ken Ikeuchi, Erina Yazaki, Kazuhei Kudo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Conserved functions of human Pelota in mRNA quality control of nonstop mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.12366"}], "href": "https://doi.org/10.1002/1873-3468.12366"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27543824"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27543824"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yann Cheli, Sachiko Kanaji, Beatrice Jacquelin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbaexp.2007.06.004"}], "href": "https://doi.org/10.1016/j.bbaexp.2007.06.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17669516"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17669516"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Eric W Mills, Jamie Wangen, Rachel Green, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamic Regulation of a Ribosome Rescue Pathway in Erythroid Cells and Platelets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.08.088"}], "href": "https://doi.org/10.1016/j.celrep.2016.08.088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27681415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27681415"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Eric W Mills, Rachel Green, Nicholas T Ingolia "}, {"type": "b", "children": [{"type": "t", "text": "Slowed decay of mRNAs enhances platelet specific translation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2016-08-736108"}], "href": "https://doi.org/10.1182/blood-2016-08-736108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28213379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28213379"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "K Pedersen, F Canals, A Prat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PELO negatively regulates HER receptor signalling and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.35"}], "href": "https://doi.org/10.1038/onc.2013.35"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23435426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23435426"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xiurong Wu, Zhang-Hua Yang, Jianfeng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2023.02.014"}], "href": "https://doi.org/10.1016/j.immuni.2023.02.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36948192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36948192"}]}]}]}
Synonyms	CGI-17, PRO1770
Proteins	PELO_HUMAN
NCBI Gene ID	53918
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

PELO has 6,877 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for PELO from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

PELO Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PELO gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of PELO gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of PELO gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of PELO gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of PELO gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of PELO gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of PELO gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of PELO gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of PELO gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of PELO gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with PELO protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PELO gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of PELO gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of PELO gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of PELO gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of PELO gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing PELO protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing PELO protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing PELO protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing PELO protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with PELO protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with PELO protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with PELO gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with PELO gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with PELO gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with PELO gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with PELO gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with PELO gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with PELO gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with PELO gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at PELO gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of PELO gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of PELO gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing PELO from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with PELO gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of PELO gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with PELO gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing PELO from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of PELO gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of PELO gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.