Name | platelet factor 4 variant 1 |
Description | The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nPF4V1, also known as CXCL4L1, has been evaluated in genetic studies for its potential impact on inflammatory disease; for example, variants in the PF4V1 gene were examined in patients with cystic fibrosis, although no significant associations were observed with lung disease severity, suggesting that its role in pulmonary inflammation may be limited in that context."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural analyses have revealed that PF4V1 differs from the classical platelet factor‐4 (CXCL4) by three C-terminal amino acids. This subtle change results in lower affinity for glycosaminoglycans and an increased diffusibility, features that are believed to contribute to its potent anti‐angiogenic activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn comprehensive reviews, PF4V1 has been highlighted as a highly potent anti‑tumoral regulator. Its ability to inhibit angiogenesis makes it an attractive candidate for modulating tumor growth, as it not only impairs neovascularization but also modulates leukocyte recruitment toward an anti‑tumoral phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nInvestigations into the cellular receptors for CXCL4L1 have demonstrated that PF4V1 effectively interacts with variants of the CXCR3 receptor. This binding is critical to its capacity to displace related chemokines from endothelial cells and to mediate downstream anti‑angiogenic effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComparative studies between PF4 and PF4V1 have shown that PF4V1 exhibits enhanced potency in suppressing angiogenesis and tumor growth. This differential activity underscores the functional importance of the modifications found in PF4V1 and supports its unique role in immune regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the cardiovascular arena, PF4V1 has been investigated as a biomarker associated with coronary artery disease. Although its exact functional contribution in heart disease remains to be fully elucidated, early clinical evaluations suggest that PF4V1 could serve as an indicator of vascular pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional research has confirmed that PF4V1 (CXCL4L1) is a highly effective anti‑angiogenic and anti‑tumor chemokine. Its distinct structural configuration compared to CXCL4 places it at the forefront of chemokine candidates with therapeutic potential in cancer treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nExperimental models have revealed that PF4V1 can cooperate with other endogenous anti‑angiogenic molecules—such as fibstatin—to inhibit both angiogenesis and lymphangiogenesis. This synergistic interaction contributes to reduced metastatic spread in tumor models, highlighting its potential in anti‑metastatic gene therapy strategies."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther dissection of intracellular signaling has indicated that PF4V1 modulates key pathways in endothelial cells. Notably, PF4V1 can attenuate ERK phosphorylation, among other kinase activities, thereby limiting endothelial cell proliferation and migration, which are essential processes in new vessel formation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, PF4V1 and its relative CXCL4 have been reviewed as potential biomarkers and therapeutic agents due to their strong anti‑angiogenic and immunomodulatory properties, offering promising avenues for targeted intervention in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies in patients with type I diabetes have revealed that PF4V1 promoter variants, which are associated with increased gene expression, may activate anti‑inflammatory pathways in mesangial cells. This upregulation is linked to higher levels of key inhibitors of inflammation, suggesting a protective role against renal inflammation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn vascular remodeling, comparative analyses using human vascular smooth muscle cells have demonstrated that PF4V1 modulates cellular behavior differently from CXCL4. Whereas PF4V1 governs aspects of cellular homeostasis, only CXCL4 robustly promotes proliferation and calcification, underlining the distinct physiological roles of these chemokines in vascular biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, emerging findings indicate that PF4V1 can participate in heterocomplex formation with atypical chemokines such as macrophage migration inhibitory factor (MIF). These heterocomplexes are implicated in the regulation of inflammatory responses, leukocyte recruitment, and platelet activation, adding a new layer of complexity to the chemokine network and offering novel targets for therapeutic modulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "A D Hillian, D Londono, J M Dunn, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Functional divergence between 2 chemokines is conferred by single amino acid change."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-03-274852"}], "href": "https://doi.org/10.1182/blood-2010-03-274852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20688960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20688960"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "A Sarabi, B K Kramp, M Drechsler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCL4L1 inhibits angiogenesis and induces undirected endothelial cell migration without affecting endothelial cell proliferation and monocyte recruitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thromb Haemost (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1538-7836.2010.04119.x"}], "href": "https://doi.org/10.1111/j.1538-7836.2010.04119.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20961394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20961394"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sofie Struyf, Laura Salogni, Marie D Burdick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Angiostatic and chemotactic activities of the CXC chemokine CXCL4L1 (platelet factor-4 variant) are mediated by CXCR3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-11-253591"}], "href": "https://doi.org/10.1182/blood-2009-11-253591"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20980681"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20980681"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jo Vandercappellen, Jo Van Damme, Sofie Struyf "}, {"type": "b", "children": [{"type": "t", "text": "The role of the CXC chemokines platelet factor-4 (CXCL4/PF-4) and its variant (CXCL4L1/PF-4var) in inflammation, angiogenesis and cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytokine Growth Factor Rev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cytogfr.2010.10.011"}], "href": "https://doi.org/10.1016/j.cytogfr.2010.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21111666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21111666"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Johan De Sutter, Nico R Van de Veire, Sofie Struyf, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PF-4var/CXCL4L1 predicts outcome in stable coronary artery disease patients with preserved left ventricular function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0031343"}], "href": "https://doi.org/10.1371/journal.pone.0031343"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22384011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22384011"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Je-Hung Kuo, Ya-Ping Chen, Jai-Shin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative C-terminal helix orientation alters chemokine function: structure of the anti-angiogenic chemokine, CXCL4L1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.455329"}], "href": "https://doi.org/10.1074/jbc.M113.455329"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23536183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23536183"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "A C Prats, L Van den Berghe, A Rayssac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CXCL4L1-fibstatin cooperation inhibits tumor angiogenesis, lymphangiogenesis and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microvasc Res (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mvr.2013.05.005"}], "href": "https://doi.org/10.1016/j.mvr.2013.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23747987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23747987"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Katrien Van Raemdonck, Mieke Gouwy, Stefanie Antoinette Lepers, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23020580"}], "href": "https://doi.org/10.3390/ijms23020580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35054772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35054772"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Markus Brandhofer, Adrian Hoffmann, Xavier Blanchet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-022-04539-0"}], "href": "https://doi.org/10.1007/s00018-022-04539-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36094626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36094626"}]}]}]}
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Synonyms | SCYB4V1, CXCL4L1, PF4A, CXCL4V1, PF4-ALT |
Proteins | PF4V_HUMAN |
NCBI Gene ID | 5197 |
API | |
Download Associations | |
Predicted Functions |
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Co-expressed Genes |
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Expression in Tissues and Cell Lines |
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PF4V1 has 2,787 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 81 datasets.
Click the + buttons to view associations for PF4V1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PF4V1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of PF4V1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of PF4V1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of PF4V1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of PF4V1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of PF4V1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of PF4V1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PF4V1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of PF4V1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of PF4V1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PF4V1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing PF4V1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with PF4V1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with PF4V1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of PF4V1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with PF4V1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with PF4V1 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by PF4V1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with PF4V1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with PF4V1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with PF4V1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with PF4V1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with PF4V1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PF4V1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of PF4V1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of PF4V1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
GAD Gene-Disease Associations | diseases associated with PF4V1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with PF4V1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of PF4V1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with PF4V1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing PF4V1 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of PF4V1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of PF4V1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of PF4V1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of PF4V1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of PF4V1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of PF4V1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving PF4V1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving PF4V1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving PF4V1 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing PF4V1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by PF4V1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by PF4V1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by PF4V1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of PF4V1 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of PF4V1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of PF4V1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of PF4V1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of PF4V1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of PF4V1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for PF4V1 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with PF4V1 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with PF4V1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for PF4V1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of PF4V1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEGG Pathways | pathways involving PF4V1 protein from the KEGG Pathways dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of PF4V1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with PF4V1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of PF4V1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of PF4V1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of PF4V1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing PF4V1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain PF4V1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by PF4V1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of PF4V1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of PF4V1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
PANTHER Pathways | pathways involving PF4V1 protein from the PANTHER Pathways dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for PF4V1 from the Pathway Commons Protein-Protein Interactions dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving PF4V1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving PF4V1 protein from the Wikipathways PFOCR 2024 dataset. | |
Reactome Pathways 2014 | pathways involving PF4V1 protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving PF4V1 protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at PF4V1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of PF4V1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of PF4V1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of PF4V1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of PF4V1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of PF4V1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with PF4V1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with PF4V1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2024 | pathways involving PF4V1 protein from the WikiPathways Pathways 2024 dataset. | |